| # | Title | Journal | Year | Citations |
|---|
| 1 | Computational pathology definitions, best practices, and recommendations for regulatory guidance: a white paper from the Digital Pathology Association | Journal of Pathology | 2019 | 263 |
| 2 | Introduction to Digital Image Analysis in Whole-slide Imaging: A White Paper from the Digital Pathology Association | Journal of Pathology Informatics | 2019 | 243 |
| 3 | High sensitivity flow cytometry of membrane vesicles | Cytometry Part A: the Journal of the International Society for Analytical Cytology | 2016 | 171 |
| 4 | Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models | Science Translational Medicine | 2018 | 136 |
| 5 | Decreased bone remodeling and porosity are associated with improved bone strength in ovariectomized cynomolgus monkeys treated with denosumab, a fully human RANKL antibody | Bone | 2011 | 92 |
| 6 | Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys | Bone | 2011 | 91 |
| 7 | Perturbation of microRNAs in Rat Heart during Chronic Doxorubicin Treatment | PLoS ONE | 2012 | 86 |
| 8 | IL-17RA Signaling in Airway Inflammation and Bronchial Hyperreactivity in Allergic Asthma | American Journal of Respiratory Cell and Molecular Biology | 2015 | 52 |
| 9 | Society of Toxicologic Pathology Digital Pathology and Image Analysis Special Interest Group Article*: Opinion on the Application of Artificial Intelligence and Machine Learning to Digital Toxicologic Pathology | Toxicologic Pathology | 2020 | 41 |
| 10 | Off-Target Platelet Activation in Macaques Unique to a Therapeutic Monoclonal Antibody | Toxicologic Pathology | 2012 | 39 |
| 11 | Differential Mitochondrial Toxicity Screening and Multi-Parametric Data Analysis | PLoS ONE | 2012 | 39 |
| 12 | Pharmacokinetics and Safety of a Fully Human Hepatocyte Growth Factor Antibody, AMG 102, in Cynomolgus Monkeys | Pharmaceutical Research | 2007 | 35 |
| 13 | Xenobiotic Perturbation of ER Stress and the Unfolded Protein Response | Toxicologic Pathology | 2013 | 33 |
| 14 | Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer’s disease | Bioorganic and Medicinal Chemistry Letters | 2015 | 30 |
| 15 | Non-Lethal Endotoxin Injection: A Rat Model of Hypercoagulability | PLoS ONE | 2017 | 28 |
| 16 | Whole-body tissue distribution study of drugs in neonate mice using desorption electrospray ionization mass spectrometry imaging | Rapid Communications in Mass Spectrometry | 2014 | 27 |
| 17 | Clinically Relevant Doses of Sclerostin Antibody Do Not Induce Osteonecrosis of the Jaw (ONJ) in Rats with Experimental Periodontitis | Journal of Bone and Mineral Research | 2019 | 27 |
| 18 | Preclinical development of AMG 139, a human antibody specifically targeting IL‐23 | British Journal of Pharmacology | 2015 | 26 |
| 19 | Rationalizing Secondary Pharmacology Screening Using Human Genetic and Pharmacological Evidence | Toxicological Sciences | 2019 | 17 |
| 20 | Survey: Immune function and immunotoxicity assessment in dogs | Journal of Immunotoxicology | 2012 | 16 |
| 21 | Prediction of clinical pharmacokinetics of AMG 181, a human anti‐ α 4 β 7 monoclonal antibody for treating inflammatory bowel diseases | Pharmacology Research and Perspectives | 2015 | 16 |
| 22 | Development of 2-aminooxazoline 3-azaxanthene β-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D | MedChemComm | 2017 | 16 |
| 23 | Evaluation of genotoxicity testing of FDA approved large molecule therapeutics | Regulatory Toxicology and Pharmacology | 2014 | 14 |
| 24 | The Automatic Proportionator Estimator Is Highly Efficient for Estimation of Total Number of Sparse Cell Populations | Frontiers in Neuroanatomy | 2018 | 12 |
| 25 | Nonclinical Safety Profile of Etelcalcetide, a Novel Peptide Calcimimetic for the Treatment of Secondary Hyperparathyroidism | International Journal of Toxicology | 2016 | 8 |
| 26 | P450-Mediated O-Demethylated Metabolite Is Responsible for Rat Hepatobiliary Toxicity of Pyridyltriazine-Containing PI3K Inhibitors | Toxicological Sciences | 2014 | 7 |
| 27 | Pharmacodynamic Model of Hepcidin Regulation of Iron Homeostasis in Cynomolgus Monkeys | AAPS Journal | 2016 | 7 |
| 28 | A Novel Statistical Algorithm for Gene Expression Analysis Helps Differentiate Pregnane X Receptor-Dependent and Independent Mechanisms of Toxicity | PLoS ONE | 2010 | 7 |
| 29 | Clinical Implications and Translation of an Off-Target Pharmacology Profiling Hit: Adenosine Uptake Inhibition In Vitro | Translational Oncology | 2019 | 5 |
| 30 | Common Handling Procedures Conducted in Preclinical Safety Studies Result in Minimal Hepatic Gene Expression Changes in Sprague-Dawley Rats | PLoS ONE | 2014 | 4 |
| 31 | Development of a BiTE®-mediated CD8+ cytotoxic T-lymphocyte activity assay to assess immunomodulatory potential of drug candidates in Cynomolgus macaque | Journal of Immunotoxicology | 2018 | 4 |
| 32 | Laser Capture Microdissection and Transcriptional Analysis of Sub-Populations of the Osteoblast Lineage from Undecalcified Bone | Methods in Molecular Biology | 2018 | 3 |
| 33 | Modeling the pharmacokinetic‐pharmacodynamic relationship of the monoclonal anti‐macaque‐ IL ‐15 antibody Hu714Mu XH u in cynomolgus monkeys | Pharmacology Research and Perspectives | 2015 | 2 |
| 34 | “Thorough QT/QTc in a Dish”: Can Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Predict Thorough QT Outcomes? | Clinical Pharmacology and Therapeutics | 2019 | 2 |
| 35 | Abstract 13907: Statin-Induced Myopathy is Mediated by Isoprenoid Depletion and is Independent of Serum Cholesterol Levels | Circulation | 2014 | 2 |
| 36 | P15.01 AMG 757, a Half-Life Extended Bispecific T-Cell Engager (HLE BiTE® Immune Therapy) Targeting DLL3, for the Treatment of Small Cell Lung Cancer | Journal of Thoracic Oncology | 2021 | 1 |
| 37 | Early De-risking Strategy for Novel Biotherapeutics | | 2013 | 0 |
