| # | Title | Journal | Year | Citations |
|---|
| 1 | ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions | BMJ, The | 2016 | 8,654 |
| 2 | Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials | BMJ: British Medical Journal | 2011 | 4,743 |
| 3 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 4 | Process evaluation of complex interventions: Medical Research Council guidance | BMJ, The | 2015 | 3,602 |
| 5 | Discovery and refinement of loci associated with lipid levels | Nature Genetics | 2013 | 2,641 |
| 6 | Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children | International Journal of Epidemiology | 2013 | 2,436 |
| 7 | Mendelian randomization: genetic anchors for causal inference in epidemiological studies | Human Molecular Genetics | 2014 | 2,402 |
| 8 | Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis | Lancet, The | 2018 | 2,076 |
| 9 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 10 | Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves | BMC Medical Research Methodology | 2012 | 1,465 |
| 11 | Aortic Pulse Wave Velocity Improves Cardiovascular Event Prediction | Journal of the American College of Cardiology | 2014 | 1,446 |
| 12 | Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption | International Journal of Epidemiology | 2017 | 1,407 |
| 13 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 14 | Consistency and inconsistency in network meta‐analysis: concepts and models for multi‐arm studies | Research Synthesis Methods | 2012 | 1,283 |
| 15 | Developing core outcome sets for clinical trials: issues to consider | Trials | 2012 | 1,226 |
| 16 | ROBIS: A new tool to assess risk of bias in systematic reviews was developed | Journal of Clinical Epidemiology | 2016 | 1,204 |
| 17 | The COMET Handbook: version 1.0 | Trials | 2017 | 1,128 |
| 18 | Basics of meta‐analysis: I2 is not an absolute measure of heterogeneity | Research Synthesis Methods | 2017 | 1,108 |
| 19 | Predicting the Functional, Molecular, and Phenotypic Consequences of Amino Acid Substitutions using Hidden Markov Models | Human Mutation | 2013 | 1,057 |
| 20 | Orienting the causal relationship between imprecisely measured traits using GWAS summary data | PLoS Genetics | 2017 | 969 |
| 21 | Bias due to participant overlap in two‐sample Mendelian randomization | Genetic Epidemiology | 2016 | 961 |
| 22 | Evaluating the Quality of Evidence from a Network Meta-Analysis | PLoS ONE | 2014 | 947 |
| 23 | Statins for the primary prevention of cardiovascular disease | The Cochrane Library | 2021 | 933 |
| 24 | Methods to estimate the between‐study variance and its uncertainty in meta‐analysis | Research Synthesis Methods | 2016 | 891 |
| 25 | Influence of Reported Study Design Characteristics on Intervention Effect Estimates From Randomized, Controlled Trials | Annals of Internal Medicine | 2012 | 880 |
| 26 | Exercise for depression | The Cochrane Library | 2013 | 859 |
| 27 | Theories of behaviour and behaviour change across the social and behavioural sciences: a scoping review | Health Psychology Review | 2015 | 822 |
| 28 | Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility | Nature Genetics | 2011 | 778 |
| 29 | Prevalence, Determinants and Patterns of Multimorbidity in Primary Care: A Systematic Review of Observational Studies | PLoS ONE | 2014 | 755 |
| 30 | Common variants associated with plasma triglycerides and risk for coronary artery disease | Nature Genetics | 2013 | 754 |
| 31 | GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment | Science | 2013 | 750 |
| 32 | Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways | Nature Genetics | 2012 | 746 |
| 33 | Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity | Nature | 2017 | 743 |
| 34 | DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis | American Journal of Human Genetics | 2016 | 717 |
| 35 | Mapping cis- and trans-regulatory effects across multiple tissues in twins | Nature Genetics | 2012 | 701 |
| 36 | Using natural experiments to evaluate population health interventions: new Medical Research Council guidance | Journal of Epidemiology and Community Health | 2012 | 696 |
| 37 | Guidance on how to develop complex interventions to improve health and healthcare | BMJ Open | 2019 | 690 |
| 38 | Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci | Nature Genetics | 2018 | 652 |
| 39 | Association of Serum Interleukin 6 and C-Reactive Protein in Childhood With Depression and Psychosis in Young Adult Life | JAMA Psychiatry | 2014 | 638 |
| 40 | Collider scope: when selection bias can substantially influence observed associations | International Journal of Epidemiology | 2018 | 631 |
| 41 | Triangulation in aetiological epidemiology | International Journal of Epidemiology | 2016 | 630 |
| 42 | The Prevalence of Non-Alcoholic Fatty Liver Disease in Children and Adolescents: A Systematic Review and Meta-Analysis | PLoS ONE | 2015 | 623 |
| 43 | Using multiple genetic variants as instrumental variables for modifiable risk factors | Statistical Methods in Medical Research | 2012 | 617 |
| 44 | Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture | Nature Genetics | 2013 | 578 |
| 45 | Guidelines for the management of oesophageal and gastric cancer | Gut | 2011 | 570 |
| 46 | Mendelian randomization of blood lipids for coronary heart disease | European Heart Journal | 2015 | 567 |
| 47 | HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials | Lancet, The | 2015 | 562 |
| 48 | Objectively measured physical activity and sedentary time in youth: the International children’s accelerometry database (ICAD) | International Journal of Behavioral Nutrition and Physical Activity | 2015 | 556 |
| 49 | Washington State Cancer Patients Found To Be At Greater Risk For Bankruptcy Than People Without A Cancer Diagnosis | Health Affairs | 2013 | 553 |
| 50 | DNA methylation aging clocks: challenges and recommendations | Genome Biology | 2019 | 552 |
