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Top Articles

#TitleJournalYearCitations
1Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamicsNature20101,274
2Reconstitution of Membrane Proteins in Phospholipid Bilayer NanodiscsMethods in Enzymology2009726
3Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4Blood2011708
4Design and synthesis of multi-haem proteinsNature1994592
5Brd4 Coactivates Transcriptional Activation of NF-κB via Specific Binding to Acetylated RelAMolecular and Cellular Biology2009505
6Glycoprotein biosynthesis in yeastFASEB Journal1993496
7Bacteriophage targeting of gut bacterium attenuates alcoholic liver diseaseNature2019493
8Polyphosphate modulates blood coagulation and fibrinolysisProceedings of the National Academy of Sciences of the United States of America2006487
9Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control AdenocarcinomaImmunity2016458
10New developments in RiPP discovery, enzymology and engineeringNatural Product Reports2021412
11Nanodiscs for structural and functional studies of membrane proteinsNature Structural and Molecular Biology2016378
12A DNAzyme-Gold Nanoparticle Probe for Uranyl Ion in Living CellsJournal of the American Chemical Society2013376
13Amphotericin forms an extramembranous and fungicidal sterol spongeNature Chemical Biology2014359
14T‐cell receptor binding affinities and kinetics: impact on T‐cell activity and specificityImmunology2009313
15Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variantsScience2021309
16Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escapeScience2021304
17How it all starts: Initiation of the clotting cascadeCritical Reviews in Biochemistry and Molecular Biology2015303
18Posttranslational modifications of NF-κB: Another layer of regulation for NF-κB signaling pathwayCellular Signalling2010285
19Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisBNature2015278
20Structure and Mechanism of the Lantibiotic Cyclase Involved in Nisin BiosynthesisScience2006275
21Polyphosphate exerts differential effects on blood clotting, depending on polymer sizeBlood2010261
22Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteriaProceedings of the National Academy of Sciences of the United States of America2010256
23Topology and reorganization of a human TFIID–promoter complexNature1996246
24A highly selective lead sensor based on a classic lead DNAzymeChemical Communications2010246
25Understanding the Role of the Essential Asp251 in Cytochrome P450cam Using Site-Directed Mutagenesis, Crystallography, and Kinetic Solvent Isotope EffectBiochemistry1998243
26New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural ProductsCell Chemical Biology2016241
27Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic TargetFrontiers in Physiology2017238
28Structure of co-crystals of tropomyosin and troponinNature1987236
29T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility ComplexImmunity2011229
30Rational design of a structural and functional nitric oxide reductaseNature2009218
31How a Single T Cell Receptor Recognizes Both Self and Foreign MHCCell2007217
32Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelAOncogene2014215
33Transcription activator‐like effector nucleases (TALENs): A highly efficient and versatile tool for genome editingBiotechnology and Bioengineering2013210
34Polyphosphate is a cofactor for the activation of factor XI by thrombinBlood2011209
35Optogenetic control of intracellular signaling pathwaysTrends in Biotechnology2015208
36Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene clusterNature Communications2013206
37Molecular dynamics simulations of membrane channels and transportersCurrent Opinion in Structural Biology2009201
38High-performance solvent suppression for proton detected solid-state NMRJournal of Magnetic Resonance2008199
39Negative regulation of NF-κB action by Set9-mediated lysine methylation of the RelA subunitEMBO Journal2009197
40Optical Control of Metal Ion Probes in Cells and Zebrafish Using Highly Selective DNAzymes Conjugated to Upconversion NanoparticlesJournal of the American Chemical Society2018196
41Lecithin-cholesterol acyltransferase in the metabolism of high-density lipoproteinsLipids and Lipid Metabolism1991194
42X-ray structures define human P2X3 receptor gating cycle and antagonist actionNature2016191
43The immune system and inflammation in breast cancerMolecular and Cellular Endocrinology2014189
44Energy transduction and alternating access of the mammalian ABC transporter P-glycoproteinNature2017189
45Factor XII inhibition reduces thrombus formation in a primate thrombosis modelBlood2014187
46Serotonin transporter–ibogaine complexes illuminate mechanisms of inhibition and transportNature2019187
47Discovery of Unique Lanthionine Synthetases Reveals New Mechanistic and Evolutionary InsightsPLoS Biology2010186
48Nanodiscs separate chemoreceptor oligomeric states and reveal their signaling propertiesProceedings of the National Academy of Sciences of the United States of America2006181
49Photocaged DNAzymes as a General Method for Sensing Metal Ions in Living CellsAngewandte Chemie - International Edition2014181
50Evolution of lanthipeptide synthetasesProceedings of the National Academy of Sciences of the United States of America2012178