| # | Title | Journal | Year | Citations |
|---|
| 1 | Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors | Nature | 1997 | 1,256 |
| 2 | FLICE is activated by association with the CD95 death-inducing signaling complex (DISC) | EMBO Journal | 1997 | 1,073 |
| 3 | Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells | Nature Medicine | 1996 | 943 |
| 4 | Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self | Nature Immunology | 2001 | 933 |
| 5 | Apoptosis signaling by death receptors | FEBS Journal | 1998 | 847 |
| 6 | FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis | Journal of Biological Chemistry | 1996 | 680 |
| 7 | Origin of monocytes and macrophages in a committed progenitor | Nature Immunology | 2013 | 523 |
| 8 | Caspases: pharmacological manipulation of cell death | Journal of Clinical Investigation | 2005 | 517 |
| 9 | Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells | Nature Medicine | 2006 | 378 |
| 10 | Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins | Journal of Cell Biology | 2001 | 357 |
| 11 | Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters | Journal of Experimental Medicine | 2004 | 317 |
| 12 | Expression of APO-1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium | International Journal of Cancer | 1994 | 282 |
| 13 | Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow | Nature Medicine | 2001 | 260 |
| 14 | Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation | Nature | 1992 | 258 |
| 15 | CD24 mediates rolling of breast carcinoma cells on P‐selectin | FASEB Journal | 1998 | 258 |
| 16 | Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment | OncoImmunology | 2015 | 227 |
| 17 | Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury | Nature Medicine | 2004 | 217 |
| 18 | Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens. | Journal of Immunology | 1992 | 216 |
| 19 | Artesunate Induces ROS-Mediated Apoptosis in Doxorubicin-Resistant T Leukemia Cells | PLoS ONE | 2007 | 211 |
| 20 | Local Fas/APO-1 (CD95) ligand-mediated tumor cell killingin vivo | European Journal of Immunology | 1995 | 205 |
| 21 | NK- and CD8+ T Cell-Mediated Eradication of Established Tumors by Peritumoral Injection of CpG-Containing Oligodeoxynucleotides | Journal of Immunology | 2001 | 202 |
| 22 | Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens | Journal of Immunology | 1992 | 198 |
| 23 | Upregulation of bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines | International Journal of Cancer | 2002 | 193 |
| 24 | The classification and diagnosis of cutaneous lupus erythematosus | Journal of Autoimmunity | 2014 | 181 |
| 25 | Promiscuous gene expression and central T-cell tolerance: more than meets the eye | Trends in Immunology | 2002 | 180 |
| 26 | Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex | European Journal of Immunology | 1997 | 165 |
| 27 | Tumor necrosis factor-related apoptosis-inducing ligand retains its apoptosis-inducing capacity on Bcl-2- or Bcl-xL-overexpressing chemotherapy-resistant tumor cells | Cancer Research | 2000 | 164 |
| 28 | CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium | Journal of Experimental Medicine | 1998 | 151 |
| 29 | Nitric Oxide–Induced Apoptosis in Human Leukemic Lines Requires Mitochondrial Lipid Degradation and Cytochrome C Release | Blood | 1999 | 145 |
| 30 | Identification of the Cytolinker Plectin as a Major Early In Vivo Substrate for Caspase 8 during CD95- and Tumor Necrosis Factor Receptor-Mediated Apoptosis | Molecular and Cellular Biology | 2000 | 144 |
| 31 | Human tumor cell modification by virus infection: an efficient and safe way to produce cancer vaccine with pleiotropic immune stimulatory properties when using Newcastle disease virus | Gene Therapy | 1999 | 141 |
| 32 | A filarial cysteine protease inhibitor down-regulates T cell proliferation and enhances interleukin-10 production | European Journal of Immunology | 1997 | 137 |
| 33 | Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells | European Journal of Immunology | 2007 | 135 |
| 34 | Tumor Cell Invasion Is Promoted by Activation of Protease Activated Receptor-1 in Cooperation with the αvβ5 Integrin | Journal of Biological Chemistry | 2001 | 134 |
| 35 | Apoptosis in cancer—implications for therapy | Seminars in Oncology | 2004 | 134 |
| 36 | Failure to induce organ-specific autoimmunity by breaking of tolerance: importance of the microenvironment | European Journal of Immunology | 1998 | 130 |
| 37 | TCR-Mediated Up-Regulation of c-FLIPshort Correlates with Resistance Toward CD95-Mediated Apoptosis by Blocking Death-Inducing Signaling Complex Activity | Journal of Immunology | 2000 | 124 |
| 38 | Molecular Mechanisms of Death-Receptor-Mediated Apoptosis | ChemBioChem | 2001 | 122 |
| 39 | S2k guideline for treatment of cutaneous lupus erythematosus – guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV) | Journal of the European Academy of Dermatology and Venereology | 2017 | 117 |
| 40 | Selection of a Broad Repertoire of CD4+ T Cells in H-2Ma0/0 Mice | Immunity | 1997 | 115 |
| 41 | Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants | Oncogene | 2003 | 111 |
| 42 | HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation | Cell Death and Differentiation | 2002 | 110 |
| 43 | TNF-Related Apoptosis-Inducing Ligand Mediates Tumoricidal Activity of Human Monocytes Stimulated by Newcastle Disease Virus | Journal of Immunology | 2003 | 97 |
| 44 | Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87–99) | European Journal of Immunology | 1996 | 96 |
| 45 | How T lymphocytes switch between life and death | European Journal of Immunology | 2006 | 94 |
| 46 | Photosensitivity, Apoptosis, and Cytokines in the Pathogenesis of Lupus Erythematosus: a Critical Review | Clinical Reviews in Allergy and Immunology | 2014 | 93 |
| 47 | HIV-1 Trans-Activator of Transcription Substitutes for Oxidative Signaling in Activation-Induced T Cell Death | Journal of Immunology | 2005 | 90 |
| 48 | Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions | Blood | 2011 | 89 |
| 49 | Caspase Activation Is Required for Nitric Oxide–Mediated, CD95(APO-1/Fas)–Dependent and Independent Apoptosis in Human Neoplastic Lymphoid Cells | Blood | 1998 | 88 |
| 50 | CD4+CD25+ regulatory T cells in human lupus erythematosus | Archives of Dermatological Research | 2009 | 88 |
