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Top Articles

#TitleJournalYearCitations
1Epidermal Growth FactorAnnual Review of Biochemistry19792,688
2ATR: an essential regulator of genome integrityNature Reviews Molecular Cell Biology20081,497
3Refinement of Triple-Negative Breast Cancer Molecular Subtypes: Implications for Neoadjuvant Chemotherapy SelectionPLoS ONE2016975
4Enhancement by N-hydroxysulfosuccinimide of water-soluble carbodiimide-mediated coupling reactionsAnalytical Biochemistry1986846
5Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptorNature1991807
6Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.Journal of Biological Chemistry1993649
7Biomarkers of Oxidative Stress Study II: Are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?Free Radical Biology and Medicine2005621
8The essential kinase ATR: ensuring faithful duplication of a challenging genomeNature Reviews Molecular Cell Biology2017589
9Lone Pair−Aromatic Interactions:  To Stabilize or Not to StabilizeAccounts of Chemical Research2007524
10Calcium-dependent Epidermal Growth Factor Receptor Transactivation Mediates the Angiotensin II-induced Mitogen-activated Protein Kinase Activation in Vascular Smooth Muscle CellsJournal of Biological Chemistry1998514
11Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic OpportunitiesCell2019498
12HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitorsCancer Cell2006426
13The stimulation of epidermal proliferation by a specific protein (EGF)Developmental Biology1965398
14Human epidermal growth factor and the proliferation of human fibroblastsJournal of Cellular Physiology1976390
15Atrial natriuretic factor in rat hypothalamus, atria and plasma: Determination by specific radioimmunoassayBiochemical and Biophysical Research Communications1984377
16Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cellsNature1976367
17AP-1: One Switch for Many SignalsExperimental Cell Research1999363
18Proteome analysis of human colon cancer by two-dimensional difference gel electrophoresis and mass spectrometryProteomics2004352
19Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometryJournal of Mass Spectrometry2003341
20Matrix Sublimation/Recrystallization for Imaging Proteins by Mass Spectrometry at High Spatial ResolutionAnalytical Chemistry2011330
21A tale of two proteins: Differential roles and regulation of Smad2 and Smad3 in TGF-β signalingJournal of Cellular Biochemistry2007321
22Molecular imaging by mass spectrometry — looking beyond classical histologyNature Reviews Cancer2010320
23Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nucleiScience1993312
24Organic ion imaging of biological tissue with secondary ion mass spectrometry and matrix-assisted laser desorption/ionizationJournal of Mass Spectrometry2001312
25An encapsulation system for the immunoisolation of pancreatic isletsNature Biotechnology1997311
26Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome StabilityCancer Cell2010305
27Insecticidal activity of essential oils: octopaminergic sites of actionComparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology2001302
28The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome StabilityMolecular Cell2015301
29From The Cover: Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinasesProceedings of the National Academy of Sciences of the United States of America2004295
30Drug metabolism by Escherichia coli expressing human cytochromes P450Nature Biotechnology1997281
31Lactobacillus casei microbiological assay of folic acid derivatives in 96-well microtiter plates.Clinical Chemistry1988276
32Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box LigasesMolecular Cell2012272
33Oestrogen protects FKBP12.6 null mice from cardiac hypertrophyNature2002271
34Structure of rat atrial natriuretic factor precursor deduced from cDNA sequenceNature1984266
35RPA and RAD51: fork reversal, fork protection, and genome stabilityNature Structural and Molecular Biology2018264
36Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in miceHepatology2008262
37Biochemical basis for the interactions of type I and type II topoisomerases with DNAHepatology1989258
38The t(8;21) fusion protein, AML1–ETO, specifically represses the transcription of the p14ARF tumor suppressor in acute myeloid leukemiaNature Medicine2002258
39Proteomics in Diagnostic PathologyAmerican Journal of Pathology2004257
40Activation of MAPKs by Angiotensin II in Vascular Smooth Muscle CellsJournal of Biological Chemistry2001252
41Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11Journal of Biological Chemistry2006249
42Atrial Natriuretic FactorJournal of Biological Chemistry1989243
43Proteomic analysis of formalin-fixed paraffin-embedded tissue by MALDI imaging mass spectrometryNature Protocols2011242
44Spatial distribution of cellular protein binding to retinoic acid in the chick limb budNature1988240
45Image fusion of mass spectrometry and microscopy: a multimodality paradigm for molecular tissue mappingNature Methods2015240
46Imaging mass spectrometry: a new tool to investigate the spatial organization of peptides and proteins in mammalian tissue sectionsCurrent Opinion in Chemical Biology2002239
47Mechanisms of cytochrome P‐450 catalysisFASEB Journal1990231
48Structural insights into the stereochemistry of the cyclooxygenase reactionNature2000222
49Target selectivity in EF-hand calcium binding proteinsBiochimica Et Biophysica Acta - Molecular Cell Research2004217
50Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response systemNature2016215