| # | Title | Journal | Year | Citations |
|---|
| 1 | Trained immunity: A program of innate immune memory in health and disease | Science | 2016 | 1,809 |
| 2 | Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity | Immunity | 2009 | 1,366 |
| 3 | Metabolic reprogramming in macrophages and dendritic cells in innate immunity | Cell Research | 2015 | 1,265 |
| 4 | Immunometabolism governs dendritic cell and macrophage function | Journal of Experimental Medicine | 2016 | 1,206 |
| 5 | Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes | Nature Immunology | 2010 | 1,149 |
| 6 | A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis | Journal of Experimental Medicine | 2006 | 911 |
| 7 | MicroRNAs: the fine-tuners of Toll-like receptor signalling | Nature Reviews Immunology | 2011 | 800 |
| 8 | T cells in multiple sclerosis and experimental autoimmune encephalomyelitis | Clinical and Experimental Immunology | 2010 | 761 |
| 9 | Structure and function of an irreversible agonist-β2 adrenoceptor complex | Nature | 2011 | 741 |
| 10 | TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity | Trends in Immunology | 2006 | 675 |
| 11 | Metabolic Reprograming in Macrophage Polarization | Frontiers in Immunology | 2014 | 649 |
| 12 | Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases | Immunity | 2009 | 611 |
| 13 | Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice | Science Translational Medicine | 2018 | 493 |
| 14 | Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 486 |
| 15 | Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation | Nature Immunology | 2006 | 468 |
| 16 | The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signaling | Nature Immunology | 2006 | 453 |
| 17 | CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis | Journal of Immunology | 2009 | 430 |
| 18 | A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis | Nature Genetics | 2007 | 411 |
| 19 | Suppression of Antitumor Immunity by IL-10 and TGF-β-Producing T Cells Infiltrating the Growing Tumor: Influence of Tumor Environment on the Induction of CD4+ and CD8+ Regulatory T Cells | Journal of Immunology | 2006 | 383 |
| 20 | Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis | Brain, Behavior, and Immunity | 2010 | 378 |
| 21 | Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice | Brain, Behavior, and Immunity | 2017 | 371 |
| 22 | TLR4 Mediates Vaccine-Induced Protective Cellular Immunity to Bordetella pertussis: Role of IL-17-Producing T Cells | Journal of Immunology | 2006 | 326 |
| 23 | Induction, function and regulation of IL‐17‐producing T cells | European Journal of Immunology | 2008 | 313 |
| 24 | Caspase-1–Processed Cytokines IL-1β and IL-18 Promote IL-17 Production by γδ and CD4 T Cells That Mediate Autoimmunity | Journal of Immunology | 2011 | 304 |
| 25 | Signalling adaptors used by Toll-like receptors: An update | Cytokine | 2008 | 300 |
| 26 | Infection with a Helminth Parasite Attenuates Autoimmunity through TGF-β-Mediated Suppression of Th17 and Th1 Responses | Journal of Immunology | 2009 | 265 |
| 27 | Targeting signal transduction as a strategy to treat inflammatory diseases | Nature Reviews Drug Discovery | 2006 | 250 |
| 28 | Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α | Molecular Cell | 2011 | 247 |
| 29 | Are the IKKs and IKK-related kinases TBK1 and IKK-ɛ similarly activated? | Trends in Biochemical Sciences | 2008 | 202 |
| 30 | Association of Delirium With Cognitive Decline in Late Life | JAMA Psychiatry | 2017 | 196 |
| 31 | Protein camouflage in cytochrome c–calixarene complexes | Nature Chemistry | 2012 | 189 |
| 32 | ExplorEnz: the primary source of the IUBMB enzyme list | Nucleic Acids Research | 2009 | 180 |
| 33 | Structure, function and regulation of the Toll/IL‐1 receptor adaptor proteins | Immunology and Cell Biology | 2007 | 178 |
| 34 | A Dimer of the Toll-Like Receptor 4 Cytoplasmic Domain Provides a Specific Scaffold for the Recruitment of Signalling Adaptor Proteins | PLoS ONE | 2007 | 166 |
| 35 | SUICIDAL IDEATION IS ASSOCIATED WITH ELEVATED INFLAMMATION IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER | Depression and Anxiety | 2013 | 166 |
| 36 | The Relationship of Omental and Subcutaneous Adipocyte Size to Metabolic Disease in Severe Obesity | PLoS ONE | 2010 | 165 |
| 37 | Inflammasome Activation by Adenylate Cyclase Toxin Directs Th17 Responses and Protection against Bordetella pertussis | Journal of Immunology | 2010 | 158 |
| 38 | Assessment of Enzyme Inhibition: A Review with Examples from the Development of Monoamine Oxidase and Cholinesterase Inhibitory Drugs | Molecules | 2017 | 156 |
| 39 | Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries | Nature Biotechnology | 2009 | 154 |
| 40 | Autophagy Regulates IL-23 Secretion and Innate T Cell Responses through Effects on IL-1 Secretion | Journal of Immunology | 2012 | 152 |
| 41 | Functional Polymorphism of the KIR3DL1/S1 Receptor on Human NK Cells | Journal of Immunology | 2007 | 150 |
| 42 | Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing | Cell Reports | 2018 | 150 |
| 43 | Schistosoma mansoni secretes a chemokine binding protein with antiinflammatory activity | Journal of Experimental Medicine | 2005 | 148 |
| 44 | Luminescent Ruthenium(II) Polypyridyl Functionalized Gold Nanoparticles; Their DNA Binding Abilities and Application As Cellular Imaging Agents | Journal of the American Chemical Society | 2011 | 141 |
| 45 | Myosin V Transports Secretory Vesicles via a Rab GTPase Cascade and Interaction with the Exocyst Complex | Developmental Cell | 2011 | 140 |
| 46 | Caspase crosstalk: integration of apoptotic and innate immune signalling pathways | Trends in Immunology | 2014 | 137 |
| 47 | Attenuating Regulatory T Cell Induction by TLR Agonists through Inhibition of p38 MAPK Signaling in Dendritic Cells Enhances Their Efficacy as Vaccine Adjuvants and Cancer Immunotherapeutics | Journal of Immunology | 2008 | 136 |
| 48 | An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation | Journal of Biological Chemistry | 2018 | 136 |
| 49 | The role of inflammasome-derived IL-1 in driving IL-17 responses | Journal of Leukocyte Biology | 2013 | 134 |
| 50 | Helminth-Modified Pulmonary Immune Response Protects Mice from Allergen-Induced Airway Hyperresponsiveness | Journal of Immunology | 2006 | 133 |
