| # | Title | Journal | Year | Citations |
|---|
| 1 | A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. | Proceedings of the National Academy of Sciences of the United States of America | 1990 | 1,789 |
| 2 | Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease | Annual Review of Pharmacology and Toxicology | 2010 | 1,510 |
| 3 | Drug Metabolism and Variability among Patients in Drug Response | New England Journal of Medicine | 2005 | 999 |
| 4 | Regulation of serotonin-2C receptor G-protein coupling by RNA editing | Nature | 1997 | 966 |
| 5 | Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders | Nature Reviews Drug Discovery | 2009 | 929 |
| 6 | Measurement of F2-isoprostanes as an index of oxidative stress in vivo | Free Radical Biology and Medicine | 2000 | 885 |
| 7 | IN VITRO AND IN VIVO DRUG INTERACTIONS INVOLVING HUMAN CYP3A | Annual Review of Pharmacology and Toxicology | 1998 | 772 |
| 8 | Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser | Nature | 2015 | 683 |
| 9 | Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 675 |
| 10 | Regulation of alternative splicing by RNA editing | Nature | 1999 | 562 |
| 11 | Negative feedback control of neuronal activity by microglia | Nature | 2020 | 520 |
| 12 | Macromolecular modeling and design in Rosetta: recent methods and frameworks | Nature Methods | 2020 | 513 |
| 13 | Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing | Clinical Pharmacology and Therapeutics | 2015 | 491 |
| 14 | Central Hypotensive Effects of the alpha 2a-Adrenergic Receptor Subtype | Science | 1996 | 466 |
| 15 | Noncyclooxygenase oxidative formation of a series of novel prostaglandins: Analytical ramifications for measurement of eicosanoids | Analytical Biochemistry | 1990 | 445 |
| 16 | Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene | Nature | 1994 | 398 |
| 17 | Preterm Resuscitation With Low Oxygen Causes Less Oxidative Stress, Inflammation, and Chronic Lung Disease | Pediatrics | 2009 | 396 |
| 18 | A genetic variant that disrupts MET transcription is associated with autism | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 389 |
| 19 | Allelic Heterogeneity at the Serotonin Transporter Locus (SLC6A4) Confers Susceptibility to Autism and Rigid-Compulsive Behaviors | American Journal of Human Genetics | 2005 | 378 |
| 20 | G protein-coupled receptor kinases: More than just kinases and not only for GPCRs | | 2012 | 368 |
| 21 | GPCR Signaling Regulation: The Role of GRKs and Arrestins | Frontiers in Pharmacology | 2019 | 358 |
| 22 | Adenosine receptors in regulation of dendritic cell differentiation and function | Blood | 2008 | 357 |
| 23 | Targeting Cell Surface Receptors with Ligand-Conjugated Nanocrystals | Journal of the American Chemical Society | 2002 | 349 |
| 24 | Structural and functional maturation of the developing primate brain | Journal of Pediatrics | 2003 | 347 |
| 25 | Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors | Cell | 2017 | 344 |
| 26 | Disrupted Bile Acid Homeostasis Reveals an Unexpected Interaction among Nuclear Hormone Receptors, Transporters, and Cytochrome P450 | Journal of Biological Chemistry | 2001 | 343 |
| 27 | Phosphorylation and Sequestration of Serotonin Transporters Differentially Modulated by Psychostimulants | Science | 1999 | 338 |
| 28 | RNA Editing of the Human Serotonin 5-Hydroxytryptamine 2C Receptor Silences Constitutive Activity | Journal of Biological Chemistry | 1999 | 333 |
| 29 | Molecular Basis of an Inherited Epilepsy | Neuron | 2002 | 325 |
| 30 | Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia | Trends in Pharmacological Sciences | 2009 | 325 |
| 31 | Neurotrophic protein S100 beta stimulates glial cell proliferation. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 320 |
| 32 | Substitution of a mutant 2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 319 |
| 33 | Evidence That Histamine Is the Causative Toxin of Scombroid-Fish Poisoning | New England Journal of Medicine | 1991 | 318 |
| 34 | Phospholipase D: Enzymology, Functionality, and Chemical Modulation | Chemical Reviews | 2011 | 314 |
| 35 | Regulation of neocortical interneuron development and the implications for neurodevelopmental disorders | Trends in Neurosciences | 2004 | 311 |
| 36 | Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks | Behavioural Brain Research | 2009 | 308 |
| 37 | Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn | Neuropsychopharmacology | 2015 | 303 |
| 38 | Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms | FASEB Journal | 1988 | 302 |
| 39 | Prenatal exposure to drugs: effects on brain development and implications for policy and education | Nature Reviews Neuroscience | 2009 | 295 |
| 40 | Changes in Intracellular Free Calcium Concentration during Illumination of Invertebrate Photoreceptors | Journal of General Physiology | 1974 | 291 |
| 41 | Serotonin and brain development | International Review of Neurobiology | 2004 | 283 |
| 42 | Impaired spatial learning in the APPSwe�+�PSEN1?E9 bigenic mouse model of Alzheimer?s disease | Genes, Brain and Behavior | 2007 | 272 |
| 43 | Clinically Actionable Genotypes Among 10,000 Patients With Preemptive Pharmacogenomic Testing | Clinical Pharmacology and Therapeutics | 2014 | 272 |
| 44 | Regulation of the TRP Ca2+ Channel by INAD in Drosophila Photoreceptors | Neuron | 1996 | 271 |
| 45 | Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy | Nature | 2002 | 271 |
| 46 | The generation and actions of isoprostanes | Lipids and Lipid Metabolism | 1997 | 270 |
| 47 | Cytochrome P4503A (CYP3A) metabolism: Prediction ofIn Vivo activity in humans | Journal of Pharmacokinetics and Pharmacodynamics | 1996 | 267 |
| 48 | Control of Oxygenation in Lipoxygenase and Cyclooxygenase Catalysis | Chemistry and Biology | 2007 | 265 |
| 49 | Two Distinct Pathways of Formation of 4-Hydroxynonenal | Journal of Biological Chemistry | 2001 | 264 |
| 50 | Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of αCaMKII inhibitory phosphorylation | Nature Neuroscience | 2007 | 260 |
