| # | Title | Journal | Year | Citations |
|---|
| 1 | Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease | Nature Genetics | 2011 | 1,676 |
| 2 | Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue. | Biological Psychiatry | 1999 | 1,395 |
| 3 | Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia | Trends in Neurosciences | 2008 | 896 |
| 4 | Cognitive Therapy vs Medications in the Treatment of Moderate to Severe Depression | Archives of General Psychiatry | 2005 | 806 |
| 5 | Harmonization of cortical thickness measurements across scanners and sites | NeuroImage | 2018 | 790 |
| 6 | The vascular depression hypothesis: mechanisms linking vascular disease with depression | Molecular Psychiatry | 2013 | 671 |
| 7 | THE EFFECTS OF PSYCHOLOGICAL STRESS ON HUMANS: INCREASED PRODUCTION OF PRO-INFLAMMATORY CYTOKINES AND Th1-LIKE RESPONSE IN STRESS-INDUCED ANXIETY | Cytokine | 1998 | 653 |
| 8 | Prevention of Relapse Following Cognitive Therapy vs Medications in Moderate to Severe Depression | Archives of General Psychiatry | 2005 | 619 |
| 9 | Development of a questionnaire for the assessment of active and passive coping strategies in chronic pain patients | Pain | 1987 | 512 |
| 10 | Dopaminergic Network Differences in Human Impulsivity | Science | 2010 | 506 |
| 11 | Definition and description of schizophrenia in the DSM-5 | Schizophrenia Research | 2013 | 491 |
| 12 | Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression | Molecular Psychiatry | 2011 | 425 |
| 13 | Lowered ω3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients | Psychiatry Research | 1999 | 408 |
| 14 | Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits | Nature Neuroscience | 2010 | 401 |
| 15 | Immune transcriptome alterations in the temporal cortex of subjects with autism | Neurobiology of Disease | 2008 | 344 |
| 16 | Effectiveness of St John's Wort in Major Depression | JAMA - Journal of the American Medical Association | 2001 | 336 |
| 17 | An extended multisensory temporal binding window in autism spectrum disorders | Experimental Brain Research | 2010 | 323 |
| 18 | Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias | PLoS Genetics | 2014 | 305 |
| 19 | The inflammatory response system in treatment-resistant schizophrenia: increased serum interleukin-6 | Schizophrenia Research | 1998 | 297 |
| 20 | Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 278 |
| 21 | Lower serum high‐density lipoprotein cholesterol (HDL‐C) in major depression and in depressed men with serious suicidal attempts: relationship with immune‐inflammatory markers | Acta Psychiatrica Scandinavica | 1997 | 270 |
| 22 | The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors | Critical Care Medicine | 2012 | 246 |
| 23 | Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study | Nature Communications | 2020 | 246 |
| 24 | Spatiotemporal Pattern of Striatal ERK1/2 Phosphorylation in a Rat Model of L-DOPA–Induced Dyskinesia and the Role of Dopamine D1 Receptors | Biological Psychiatry | 2007 | 245 |
| 25 | Hippocampal interneurons are abnormal in schizophrenia | Schizophrenia Research | 2011 | 245 |
| 26 | Patterns and mental health predictors of domestic violence in the United States | International Journal of Law and Psychiatry | 2001 | 240 |
| 27 | Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo | Psychopharmacology | 2009 | 240 |
| 28 | Serotonin Subtype 2 Receptor Genes and Clinical Response to Clozapine in Schizophrenia Patients | Neuropsychopharmacology | 1998 | 220 |
| 29 | The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression | Journal of Affective Disorders | 1998 | 217 |
| 30 | GABAergic mechanisms of hippocampal hyperactivity in schizophrenia | Schizophrenia Research | 2015 | 211 |
| 31 | Immunotherapy with interferon-alpha in patients affected by chronic hepatitis C induces an intercorrelated stimulation of the cytokine network and an increase in depressive and anxiety symptoms | Psychiatry Research | 2001 | 207 |
| 32 | Somatosensory processing in neurodevelopmental disorders | Journal of Neurodevelopmental Disorders | 2010 | 197 |
| 33 | Catatonia in DSM-5 | Schizophrenia Research | 2013 | 194 |
| 34 | Abnormal Reward System Activation in Mania | Neuropsychopharmacology | 2008 | 190 |
| 35 | Common variants conferring risk of schizophrenia: A pathway analysis of GWAS data | Schizophrenia Research | 2010 | 190 |
| 36 | Sexual dysfunctions in depression | Archives of Sexual Behavior | 1982 | 183 |
| 37 | Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation | Life Sciences | 2002 | 177 |
| 38 | Disruption of cerebral cortex MET signaling in autism spectrum disorder | Annals of Neurology | 2007 | 176 |
| 39 | Trends in Prescribing of Antipsychotic Medications for US Children | Academic Pediatrics | 2006 | 173 |
| 40 | Neurodevelopment, GABA System Dysfunction, and Schizophrenia | Neuropsychopharmacology | 2015 | 172 |
| 41 | In vivo immunomodulatory effects of clozapine in schizophrenia | Schizophrenia Research | 1997 | 171 |
| 42 | Structure of the psychotic disorders classification in DSM‐5 | Schizophrenia Research | 2013 | 170 |
| 43 | Logic and justification for dimensional assessment of symptoms and related clinical phenomena in psychosis: Relevance to DSM-5 | Schizophrenia Research | 2013 | 165 |
| 44 | A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophrenia | Molecular Psychiatry | 2000 | 164 |
| 45 | Treatment of opioid-dependent pregnant women: Clinical and research issues | Journal of Substance Abuse Treatment | 2008 | 164 |
| 46 | Hippocampal Pathology in Schizophrenia | Current Topics in Behavioral Neurosciences | 2010 | 158 |
| 47 | Serum levels of excitatory amino acids, serine, glycine, histidine, threonine, taurine, alanine and arginine in treatment‐resistant depression: modulation by treatment with antidepressants and prediction of clinical responsivity | Acta Psychiatrica Scandinavica | 1998 | 156 |
| 48 | Attenuated psychosis syndrome in DSM-5 | Schizophrenia Research | 2013 | 155 |
| 49 | Buprenorphine treatment of opioid‐dependent pregnant women: a comprehensive review | Addiction | 2012 | 151 |
| 50 | The rubber hand illusion in children with autism spectrum disorders: delayed influence of combined tactile and visual input on proprioception | Autism | 2012 | 150 |
