| # | Title | Journal | Year | Citations |
|---|
| 1 | Amount of Time Spent in Sedentary Behaviors in the United States, 2003-2004 | American Journal of Epidemiology | 2008 | 2,093 |
| 2 | Endothelial-to-mesenchymal transition contributes to cardiac fibrosis | Nature Medicine | 2007 | 1,862 |
| 3 | Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype | Science | 1995 | 1,349 |
| 4 | Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use | Nature Genetics | 2019 | 1,307 |
| 5 | Increase in Circulating Products of Lipid Peroxidation (F2-Isoprostanes) in Smokers — Smoking as a Cause of Oxidative Damage | New England Journal of Medicine | 1995 | 1,300 |
| 6 | TGF- Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia | Science | 2004 | 1,279 |
| 7 | Evidence that fibroblasts derive from epithelium during tissue fibrosis | Journal of Clinical Investigation | 2002 | 1,098 |
| 8 | Current Perspectives on Statins | Circulation | 2000 | 1,078 |
| 9 | Refinement of Triple-Negative Breast Cancer Molecular Subtypes: Implications for Neoadjuvant Chemotherapy Selection | PLoS ONE | 2016 | 975 |
| 10 | Diabetes in Older Adults | Diabetes Care | 2012 | 961 |
| 11 | PROSTANOIDRECEPTORS: Subtypes and Signaling | Annual Review of Pharmacology and Toxicology | 2001 | 927 |
| 12 | Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits | Nature Genetics | 2018 | 924 |
| 13 | Helicobacter pylori: gastric cancer and beyond | Nature Reviews Cancer | 2010 | 920 |
| 14 | Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury | Kidney International | 2009 | 888 |
| 15 | Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor | Nature | 1991 | 807 |
| 16 | Case Definition and Phenotype Standardization in Drug-Induced Liver Injury | Clinical Pharmacology and Therapeutics | 2011 | 773 |
| 17 | Association between Body-Mass Index and Risk of Death in More Than 1 Million Asians | New England Journal of Medicine | 2011 | 730 |
| 18 | EGF receptor ligands | Experimental Cell Research | 2003 | 678 |
| 19 | Balanced Crystalloids versus Saline in Noncritically Ill Adults | New England Journal of Medicine | 2018 | 652 |
| 20 | Assessment of Human Pancreatic Islet Architecture and Composition by Laser Scanning Confocal Microscopy | Journal of Histochemistry and Cytochemistry | 2005 | 647 |
| 21 | Pathobiology of Helicobacter pylori–Induced Gastric Cancer | Gastroenterology | 2016 | 638 |
| 22 | Clinical Relevance of Biomarkers of Oxidative Stress | Antioxidants and Redox Signaling | 2015 | 604 |
| 23 | Medical and Surgical Treatment of Parapneumonic Effusions | Chest | 2000 | 600 |
| 24 | Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence. | Circulation | 1990 | 599 |
| 25 | Clinical Care Guidelines for Cystic Fibrosis–Related Diabetes | Diabetes Care | 2010 | 582 |
| 26 | Acute motor axonal neuropathy: A frequent cause of acute flaccid paralysis in China | Annals of Neurology | 1993 | 572 |
| 27 | Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man | Metabolism: Clinical and Experimental | 1981 | 562 |
| 28 | Acute Respiratory Distress Syndrome Subphenotypes Respond Differently to Randomized Fluid Management Strategy | American Journal of Respiratory and Critical Care Medicine | 2017 | 557 |
| 29 | Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention | Gastroenterology | 2000 | 555 |
| 30 | Identification of an Acquired JAK2 Mutation in Polycythemia Vera | Journal of Biological Chemistry | 2005 | 548 |
| 31 | Rare and low-frequency coding variants alter human adult height | Nature | 2017 | 544 |
| 32 | Orthostatic Intolerance and Tachycardia Associated with Norepinephrine-Transporter Deficiency | New England Journal of Medicine | 2000 | 534 |
| 33 | Clinical Risk Factors for Primary Graft Dysfunction after Lung Transplantation | American Journal of Respiratory and Critical Care Medicine | 2013 | 529 |
| 34 | Temporal self-regulation of transposition through host-independent transposase rodlet formation | Nucleic Acids Research | 2017 | 526 |
| 35 | Mammalian collagen IV | Microscopy Research and Technique | 2008 | 517 |
| 36 | Bronchopulmonary Dysplasia: Executive Summary of a Workshop | Journal of Pediatrics | 2018 | 516 |
| 37 | Detectable clonal mosaicism from birth to old age and its relationship to cancer | Nature Genetics | 2012 | 511 |
| 38 | The Association of Diabetes and Glucose Control With Surgical-Site Infections Among Cardiothoracic Surgery Patients | Infection Control and Hospital Epidemiology | 2001 | 503 |
| 39 | COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease | Lancet, The | 2002 | 501 |
| 40 | TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer | Journal of Clinical Investigation | 2013 | 495 |
| 41 | Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing | Clinical Pharmacology and Therapeutics | 2015 | 491 |
| 42 | Inflammasome-regulated Cytokines Are Critical Mediators of Acute Lung Injury | American Journal of Respiratory and Critical Care Medicine | 2012 | 469 |
| 43 | Effectiveness and Safety of the Awakening and Breathing Coordination, Delirium Monitoring/Management, and Early Exercise/Mobility Bundle* | Critical Care Medicine | 2014 | 442 |
| 44 | Reducing Hospital Readmission Rates: Current Strategies and Future Directions | Annual Review of Medicine | 2014 | 436 |
| 45 | GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability | Nature Neuroscience | 2018 | 436 |
| 46 | RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors | Clinical Cancer Research | 2016 | 428 |
| 47 | MedEx: a medication information extraction system for clinical narratives | Journal of the American Medical Informatics Association: JAMIA | 2010 | 427 |
| 48 | HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors | Cancer Cell | 2006 | 426 |
| 49 | Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis | Nature Medicine | 2009 | 426 |
| 50 | PiggyBac Transposon-mediated Gene Transfer in Human Cells | Molecular Therapy | 2007 | 425 |
