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Top Articles

#TitleJournalYearCitations
1Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy20164,701
2The BioGRID interaction database: 2019 updateNucleic Acids Research20191,096
3The BioGRID interaction database: 2017 updateNucleic Acids Research2017920
4The BioGRID interaction database: 2015 updateNucleic Acids Research2015868
5The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactionsProtein Science2021769
6The MC-Fold and MC-Sym pipeline infers RNA structure from sequence dataNature2008726
7Chromatin Challenges during DNA Replication and RepairCell2007669
8The BioGRID interaction database: 2013 updateNucleic Acids Research2012643
9ERK signalling: a master regulator of cell behaviour, life and fateNature Reviews Molecular Cell Biology2020535
10Drug combinations: a strategy to extend the life of antibiotics in the 21st centuryNature Reviews Microbiology2019526
11Regulation of RAF protein kinases in ERK signallingNature Reviews Molecular Cell Biology2015506
12Genomic Islands in the Pathogenic Filamentous Fungus Aspergillus fumigatusPLoS Genetics2008473
13Autism-related deficits via dysregulated eIF4E-dependent translational controlNature2013451
14Probing the activation-promoted structural rearrangements in preassembled receptor–G protein complexesNature Structural and Molecular Biology2006390
15mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 SignalingMolecular and Cellular Biology2010365
16Regulation and function of the RSK family of protein kinasesBiochemical Journal2012326
17Actin cortex architecture regulates cell surface tensionNature Cell Biology2017325
18The evasive nature of drug efficacy: implications for drug discoveryTrends in Pharmacological Sciences2007324
19Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functionsMolecular Systems Biology2013284
20Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosisProceedings of the National Academy of Sciences of the United States of America2017281
21The Sirtuins Hst3 and Hst4p Preserve Genome Integrity by Controlling Histone H3 Lysine 56 DeacetylationCurrent Biology2006280
22Restructuring G-Protein- Coupled Receptor ActivationCell2012247
23eIF4E is a central node of an RNA regulon that governs cellular proliferationJournal of Cell Biology2006246
24A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemiaGenes and Development2012238
25Inhibition of RAS function through targeting an allosteric regulatory siteNature Chemical Biology2017237
26Signaling Pathways Involved in the Regulation of mRNA TranslationMolecular and Cellular Biology2018236
27MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In VivoCancer Cell2012229
28Changes in flagellin glycosylation affect Campylobacter autoagglutination and virulenceMolecular Microbiology2006227
29Cellular Control of Cortical Actin NucleationCurrent Biology2014219
30CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral EscapeCell Reports2016215
31Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates TranslationCell2010211
32Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading framesNature Communications2016210
33The Phagosomal Proteome in Interferon-γ-Activated MacrophagesImmunity2009206
34WD40 repeat domain proteins: a novel target class?Nature Reviews Drug Discovery2017202
35A comprehensive map of the mTOR signaling networkMolecular Systems Biology2010201
36The RSK factors of activating the Ras/MAPK signaling cascadeFrontiers in Bioscience - Landmark2008183
37H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 MethylationPLoS Genetics2011175
38The MHC class I peptide repertoire is molded by the transcriptomeJournal of Experimental Medicine2008174
39Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivoProceedings of the National Academy of Sciences of the United States of America2007172
40Hedgehog-Gli Pathway Activation during Kidney FibrosisAmerican Journal of Pathology2012171
41Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem CellsCancer Cell2016169
42Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9Science Signaling2018169
43eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3′UTRJournal of Cell Biology2005166
44Caenorhabditis elegans is a useful model for anthelmintic discoveryNature Communications2015163
45Chromatin Regulatory Mechanisms in PluripotencyAnnual Review of Cell and Developmental Biology2010161
46Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser863 and Multisite PhosphorylationJournal of Biological Chemistry2010158
47Structural insights into binding specificity, efficacy and bias of a β2AR partial agonistNature Chemical Biology2018155
48GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivoBlood2016148
49Functional Selective Oxytocin-derived Agonists Discriminate between Individual G Protein Family SubtypesJournal of Biological Chemistry2012147
50Regulation of mRNA Translation by Signaling PathwaysCold Spring Harbor Perspectives in Biology2012146