# | Title | Journal | Year | Citations |
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1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
2 | The BioGRID interaction database: 2019 update | Nucleic Acids Research | 2019 | 1,096 |
3 | The BioGRID interaction database: 2017 update | Nucleic Acids Research | 2017 | 920 |
4 | The BioGRID interaction database: 2015 update | Nucleic Acids Research | 2015 | 868 |
5 | The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions | Protein Science | 2021 | 769 |
6 | The MC-Fold and MC-Sym pipeline infers RNA structure from sequence data | Nature | 2008 | 726 |
7 | Chromatin Challenges during DNA Replication and Repair | Cell | 2007 | 669 |
8 | The BioGRID interaction database: 2013 update | Nucleic Acids Research | 2012 | 643 |
9 | ERK signalling: a master regulator of cell behaviour, life and fate | Nature Reviews Molecular Cell Biology | 2020 | 535 |
10 | Drug combinations: a strategy to extend the life of antibiotics in the 21st century | Nature Reviews Microbiology | 2019 | 526 |
11 | Regulation of RAF protein kinases in ERK signalling | Nature Reviews Molecular Cell Biology | 2015 | 506 |
12 | Genomic Islands in the Pathogenic Filamentous Fungus Aspergillus fumigatus | PLoS Genetics | 2008 | 473 |
13 | Autism-related deficits via dysregulated eIF4E-dependent translational control | Nature | 2013 | 451 |
14 | Probing the activation-promoted structural rearrangements in preassembled receptor–G protein complexes | Nature Structural and Molecular Biology | 2006 | 390 |
15 | mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling | Molecular and Cellular Biology | 2010 | 365 |
16 | Regulation and function of the RSK family of protein kinases | Biochemical Journal | 2012 | 326 |
17 | Actin cortex architecture regulates cell surface tension | Nature Cell Biology | 2017 | 325 |
18 | The evasive nature of drug efficacy: implications for drug discovery | Trends in Pharmacological Sciences | 2007 | 324 |
19 | Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions | Molecular Systems Biology | 2013 | 284 |
20 | Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis | Proceedings of the National Academy of Sciences of the United States of America | 2017 | 281 |
21 | The Sirtuins Hst3 and Hst4p Preserve Genome Integrity by Controlling Histone H3 Lysine 56 Deacetylation | Current Biology | 2006 | 280 |
22 | Restructuring G-Protein- Coupled Receptor Activation | Cell | 2012 | 247 |
23 | eIF4E is a central node of an RNA regulon that governs cellular proliferation | Journal of Cell Biology | 2006 | 246 |
24 | A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia | Genes and Development | 2012 | 238 |
25 | Inhibition of RAS function through targeting an allosteric regulatory site | Nature Chemical Biology | 2017 | 237 |
26 | Signaling Pathways Involved in the Regulation of mRNA Translation | Molecular and Cellular Biology | 2018 | 236 |
27 | MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo | Cancer Cell | 2012 | 229 |
28 | Changes in flagellin glycosylation affect Campylobacter autoagglutination and virulence | Molecular Microbiology | 2006 | 227 |
29 | Cellular Control of Cortical Actin Nucleation | Current Biology | 2014 | 219 |
30 | CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape | Cell Reports | 2016 | 215 |
31 | Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation | Cell | 2010 | 211 |
32 | Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames | Nature Communications | 2016 | 210 |
33 | The Phagosomal Proteome in Interferon-γ-Activated Macrophages | Immunity | 2009 | 206 |
34 | WD40 repeat domain proteins: a novel target class? | Nature Reviews Drug Discovery | 2017 | 202 |
35 | A comprehensive map of the mTOR signaling network | Molecular Systems Biology | 2010 | 201 |
36 | The RSK factors of activating the Ras/MAPK signaling cascade | Frontiers in Bioscience - Landmark | 2008 | 183 |
37 | H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation | PLoS Genetics | 2011 | 175 |
38 | The MHC class I peptide repertoire is molded by the transcriptome | Journal of Experimental Medicine | 2008 | 174 |
39 | Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 172 |
40 | Hedgehog-Gli Pathway Activation during Kidney Fibrosis | American Journal of Pathology | 2012 | 171 |
41 | Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells | Cancer Cell | 2016 | 169 |
42 | Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9 | Science Signaling | 2018 | 169 |
43 | eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3′UTR | Journal of Cell Biology | 2005 | 166 |
44 | Caenorhabditis elegans is a useful model for anthelmintic discovery | Nature Communications | 2015 | 163 |
45 | Chromatin Regulatory Mechanisms in Pluripotency | Annual Review of Cell and Developmental Biology | 2010 | 161 |
46 | Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser863 and Multisite Phosphorylation | Journal of Biological Chemistry | 2010 | 158 |
47 | Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist | Nature Chemical Biology | 2018 | 155 |
48 | GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo | Blood | 2016 | 148 |
49 | Functional Selective Oxytocin-derived Agonists Discriminate between Individual G Protein Family Subtypes | Journal of Biological Chemistry | 2012 | 147 |
50 | Regulation of mRNA Translation by Signaling Pathways | Cold Spring Harbor Perspectives in Biology | 2012 | 146 |