| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation | Nature Cell Biology | 2012 | 646 |
| 3 | De novo mutations in the gene encoding the synaptic scaffolding proteinSHANK3in patients ascertained for schizophrenia | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 361 |
| 4 | From glutamate co-release to vesicular synergy: vesicular glutamate transporters | Nature Reviews Neuroscience | 2011 | 321 |
| 5 | Potential clinical relevance of the ‘little brain’ on the mammalian heart | Experimental Physiology | 2008 | 312 |
| 6 | Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells | Nature Immunology | 2016 | 305 |
| 7 | Metabolic and Additional Vascular Effects of Thiazolidinediones | Drugs | 2002 | 265 |
| 8 | Quantum dot-induced cell death involves Fas upregulation and lipid peroxidation in human neuroblastoma cells | Journal of Nanobiotechnology | 2007 | 261 |
| 9 | Vascular Endothelial Growth Factor Effect on Endothelial Cell Proliferation, Migration, and Platelet-activating Factor Synthesis Is Flk-1-dependent | Journal of Biological Chemistry | 1999 | 250 |
| 10 | Dynamic Nature of Atrial Fibrillation Substrate During Development and Reversal of Heart Failure in Dogs | Circulation | 2002 | 226 |
| 11 | Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis | Oncogene | 2000 | 224 |
| 12 | Direct Measure of the De Novo Mutation Rate in Autism and Schizophrenia Cohorts | American Journal of Human Genetics | 2010 | 222 |
| 13 | The Antidiabetic Potential of Quercetin: Underlying Mechanisms | Current Medicinal Chemistry | 2017 | 207 |
| 14 | Phosphorylation of IκBα in the C-Terminal PEST Domain by Casein Kinase II Affects Intrinsic Protein Stability | Molecular and Cellular Biology | 1996 | 206 |
| 15 | Cardiac neuronal hierarchy in health and disease | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | 2004 | 195 |
| 16 | Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib | Annals of the Rheumatic Diseases | 2016 | 194 |
| 17 | The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2 – therapy | Canadian Journal of Cardiology | 2010 | 191 |
| 18 | Ionic Mechanisms of Regional Action Potential Heterogeneity in the Canine Right Atrium | Circulation Research | 1998 | 186 |
| 19 | Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1 | Nature Medicine | 2016 | 183 |
| 20 | Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells | Current Biology | 1995 | 174 |
| 21 | Stimulation of AMP-activated protein kinase and enhancement of basal glucose uptake in muscle cells by quercetin and quercetin glycosides, active principles of the antidiabetic medicinal plant Vaccinium vitis-idaea | Molecular Nutrition and Food Research | 2010 | 167 |
| 22 | Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats | Journal of Ethnopharmacology | 2009 | 163 |
| 23 | How fast and how often: The pharmacokinetics of drug use are decisive in addiction | Neuroscience and Biobehavioral Reviews | 2015 | 160 |
| 24 | Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation | Genes and Development | 2013 | 158 |
| 25 | Anti-inflammatory activity of chondroitin sulfate | Osteoarthritis and Cartilage | 2008 | 156 |
| 26 | Immunomodulatory and anti‐inflammatory effects of chondroitin sulphate | Journal of Cellular and Molecular Medicine | 2009 | 156 |
| 27 | Inhibition of Growth Factor-induced Protein Synthesis by a Selective MEK Inhibitor in Aortic Smooth Muscle Cells | Journal of Biological Chemistry | 1996 | 151 |
| 28 | Dopamine neurons in culture express VGLUT2 explaining their capacity to release glutamate at synapses in addition to dopamine | Journal of Neurochemistry | 2004 | 143 |
| 29 | G protein-coupled receptors stimulation and the control of cell migration | Cellular Signalling | 2009 | 143 |
| 30 | Attenuation of morphine tolerance and dependence with the highly selective δ-opioid receptor antagonist TIPP[ψ] | European Journal of Pharmacology | 1995 | 140 |
| 31 | Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: Role of PI3K, PKC and PLC pathways | British Journal of Pharmacology | 2002 | 139 |
| 32 | The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias | Nature Genetics | 2015 | 132 |
| 33 | Serotonin Upregulates Mitogen-Stimulated B Lymphocyte Proliferation through 5-HT1AReceptors | Cellular Immunology | 1995 | 130 |
| 34 | Plants used by the Cree Nation of Eeyou Istchee (Quebec, Canada) for the treatment of diabetes: A novel approach in quantitative ethnobotany | Journal of Ethnopharmacology | 2006 | 129 |
| 35 | Differential Regulation of P27Kip1 Expression by Mitogenic and Hypertrophic Factors | Journal of Cell Biology | 2000 | 126 |
| 36 | Lipoic acid prevents hypertension, hyperglycemia, and the increase in heart mitochondrial superoxide production | American Journal of Hypertension | 2003 | 126 |
| 37 | The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat | Journal of Ethnopharmacology | 2004 | 123 |
| 38 | VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioral activation | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 123 |
| 39 | Determination of bile acids in biological fluids by liquid chromatography-electrospray tandem mass spectrometry | Journal of Lipid Research | 2001 | 122 |
| 40 | The multilingual nature of dopamine neurons | Progress in Brain Research | 2014 | 121 |
| 41 | Intracellular calcium changes and tachycardia-induced contractile dysfunction in canine atrial myocytes | Cardiovascular Research | 2001 | 119 |
| 42 | Remote control of the permeability of the blood–brain barrier by magnetic heating of nanoparticles: A proof of concept for brain drug delivery | Journal of Controlled Release | 2015 | 118 |
| 43 | Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: A new model of neuropathic pain | Neuroscience | 2005 | 117 |
| 44 | Human mesenchymal stromal cell-secreted lactate induces M2-macrophage differentiation by metabolic reprogramming | Oncotarget | 2016 | 116 |
| 45 | Fludrocortisone for the Prevention of Vasovagal Syncope | Journal of the American College of Cardiology | 2016 | 116 |
| 46 | Endothelin A Receptor Blockade Causes Adverse Left Ventricular Remodeling but Improves Pulmonary Artery Pressure After Infarction in the Rat | Circulation | 1998 | 114 |
| 47 | The 2006 Canadian Hypertension Education Program recommendations for the management of hypertension: Part II – Therapy | Canadian Journal of Cardiology | 2006 | 113 |
| 48 | The role of neurotensin in central nervous system pathophysiology: what is the evidence? | Journal of Psychiatry and Neuroscience | 2006 | 112 |
| 49 | Vascular Endothelial Growth Factor (VEGF)-A165-induced Prostacyclin Synthesis Requires the Activation of VEGF Receptor-1 and -2 Heterodimer | Journal of Biological Chemistry | 2005 | 111 |
| 50 | Localization of multiple neurotransmitters in surgically derived specimens of human atrial ganglia | Neuroscience | 2009 | 109 |
