| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial | Lancet, The | 2002 | 2,331 |
| 3 | 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation | Heart Rhythm | 2017 | 1,671 |
| 4 | Acarbose Treatment and the Risk of Cardiovascular Disease and Hypertension in Patients With Impaired Glucose Tolerance | JAMA - Journal of the American Medical Association | 2003 | 1,448 |
| 5 | TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis | Nature Genetics | 2008 | 1,371 |
| 6 | On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection | New England Journal of Medicine | 2015 | 1,302 |
| 7 | Discrepancies between Meta-Analyses and Subsequent Large Randomized, Controlled Trials | New England Journal of Medicine | 1997 | 1,261 |
| 8 | Inflammatory Cytokine Alterations in Schizophrenia: A Systematic Quantitative Review | Biological Psychiatry | 2008 | 883 |
| 9 | Incidence, risk factors and consequences of ICU delirium | Intensive Care Medicine | 2007 | 869 |
| 10 | 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation | Europace | 2018 | 767 |
| 11 | Inspiratory Muscle Unloading by Neurally Adjusted Ventilatory Assist During Maximal Inspiratory Efforts in Healthy Subjects | Chest | 2007 | 729 |
| 12 | Cellular and Molecular Basis of Pulmonary Arterial Hypertension | Journal of the American College of Cardiology | 2009 | 714 |
| 13 | Effects of Angiotensin-Converting Enzyme Inhibition on the Development of the Atrial Fibrillation Substrate in Dogs With Ventricular Tachypacing–Induced Congestive Heart Failure | Circulation | 2001 | 646 |
| 14 | Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study | Lancet, The | 2013 | 624 |
| 15 | PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial | Lancet, The | 2015 | 615 |
| 16 | Neural control of mechanical ventilation in respiratory failure | Nature Medicine | 1999 | 573 |
| 17 | Characterizing the profile of obese patients who are metabolically healthy | International Journal of Obesity | 2011 | 530 |
| 18 | Cellular and Molecular Electrophysiology of Atrial Fibrillation Initiation, Maintenance, and Progression | Circulation Research | 2014 | 530 |
| 19 | Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal | Science | 2014 | 470 |
| 20 | Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging | Annals of the Rheumatic Diseases | 2005 | 459 |
| 21 | Nef Harbors a Major Determinant of Pathogenicity for an AIDS-like Disease Induced by HIV-1 in Transgenic Mice | Cell | 1998 | 444 |
| 22 | The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein | Cancer Cell | 2005 | 433 |
| 23 | Compression stockings to prevent post-thrombotic syndrome: a randomised placebo-controlled trial | Lancet, The | 2014 | 425 |
| 24 | Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury | Neurochemistry International | 2006 | 393 |
| 25 | Cellular and Molecular Mechanisms of Atrial Arrhythmogenesis in Patients With Paroxysmal Atrial Fibrillation | Circulation | 2014 | 386 |
| 26 | 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary | Europace | 2018 | 375 |
| 27 | The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm | Journal of Viral Hepatitis | 2014 | 372 |
| 28 | De novo mutations in the gene encoding the synaptic scaffolding proteinSHANK3in patients ascertained for schizophrenia | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 361 |
| 29 | Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine | Hepatology | 2010 | 353 |
| 30 | 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary | Journal of Arrhythmia | 2017 | 348 |
| 31 | Cryoballoon or Radiofrequency Ablation for Atrial Fibrillation Assessed by Continuous Monitoring | Circulation | 2019 | 345 |
| 32 | Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects | Journal of Allergy and Clinical Immunology | 2018 | 344 |
| 33 | Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trial | Gene Therapy | 2013 | 336 |
| 34 | Reevaluation of Diagnosis in Adults With Physician-Diagnosed Asthma | JAMA - Journal of the American Medical Association | 2017 | 336 |
| 35 | Comparison of Clinical Outcomes and Adverse Events Associated With Glucose-Lowering Drugs in Patients With Type 2 Diabetes | JAMA - Journal of the American Medical Association | 2016 | 329 |
| 36 | Utility of whole‐exome sequencing for those near the end of the diagnostic odyssey: time to address gaps in care | Clinical Genetics | 2016 | 323 |
| 37 | BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation | Nature | 2017 | 308 |
| 38 | Glucolipotoxicity of the pancreatic beta cell | Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids | 2010 | 307 |
| 39 | Clinical and statistical validity of conventional prognostic factors in predicting short-term survival among cirrhotics | Hepatology | 1987 | 303 |
| 40 | Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies—a consensus statement from the European Atherosclerosis Society | European Heart Journal | 2021 | 303 |
| 41 | Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 300 |
| 42 | Diagnosis of Asymptomatic Primary Hyperparathyroidism: Proceedings of the Fourth International Workshop | Journal of Clinical Endocrinology and Metabolism | 2014 | 296 |
| 43 | Perioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant | JAMA Internal Medicine | 2019 | 283 |
| 44 | The RECOVER Program: Disability Risk Groups and 1-Year Outcome after 7 or More Days of Mechanical Ventilation | American Journal of Respiratory and Critical Care Medicine | 2016 | 272 |
| 45 | SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations | Journal of Medical Genetics | 2010 | 266 |
| 46 | Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia | Molecular Psychiatry | 2011 | 260 |
| 47 | Boc is a receptor for sonic hedgehog in the guidance of commissural axons | Nature | 2006 | 259 |
| 48 | Guidelines for Premeal Insulin Dose Reduction for Postprandial Exercise of Different Intensities and Durations in Type 1 Diabetic Subjects Treated Intensively With a Basal-Bolus Insulin Regimen (Ultralente-Lispro) | Diabetes Care | 2001 | 256 |
| 49 | Atrial Fibrillation Promotion by Endurance Exercise | Journal of the American College of Cardiology | 2013 | 252 |
| 50 | Major proteins of bovine seminal plasma exhibit novel interactions with phospholipid. | Journal of Biological Chemistry | 1992 | 251 |
