| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Drug Delivery Systems: Entering the Mainstream | Science | 2004 | 4,028 |
| 3 | Gut Microbiota in Health and Disease | Physiological Reviews | 2010 | 3,287 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 5 | Accurate prediction of protein structures and interactions using a three-track neural network | Science | 2021 | 2,843 |
| 6 | Classification of Intrinsically Disordered Regions and Proteins | Chemical Reviews | 2014 | 1,618 |
| 7 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 8 | Rational design of cationic lipids for siRNA delivery | Nature Biotechnology | 2010 | 1,366 |
| 9 | Enteropathogenic E. coli (EPEC) Transfers Its Receptor for Intimate Adherence into Mammalian Cells | Cell | 1997 | 1,143 |
| 10 | Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion | Nature Cell Biology | 2007 | 888 |
| 11 | Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo** | Angewandte Chemie - International Edition | 2012 | 843 |
| 12 | Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3 | Science | 2000 | 720 |
| 13 | Lipid Nanoparticle Systems for Enabling Gene Therapies | Molecular Therapy | 2017 | 632 |
| 14 | Non-thermal heat-shock response to microwaves | Nature | 2000 | 584 |
| 15 | The current landscape of nucleic acid therapeutics | Nature Nanotechnology | 2021 | 578 |
| 16 | Matrix Metalloproteinase Activity Inactivates the CXC Chemokine Stromal Cell-derived Factor-1 | Journal of Biological Chemistry | 2001 | 576 |
| 17 | The mTOR Pathway in the Control of Protein Synthesis | Physiology | 2006 | 549 |
| 18 | Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products | Nature Biotechnology | 2010 | 510 |
| 19 | On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids | Gene Therapy | 2001 | 508 |
| 20 | SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex | Science | 2022 | 488 |
| 21 | Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance | Nature | 2014 | 461 |
| 22 | Assembly, structure, function and regulation of type III secretion systems | Nature Reviews Microbiology | 2017 | 456 |
| 23 | Antibiotic-Induced Perturbations of the Intestinal Microbiota Alter Host Susceptibility to Enteric Infection | Infection and Immunity | 2008 | 445 |
| 24 | Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA | Molecular Therapy - Nucleic Acids | 2012 | 445 |
| 25 | Signalling to translation: how signal transduction pathways control the protein synthetic machinery | Biochemical Journal | 2007 | 443 |
| 26 | Genomic and Biochemical Insights into the Specificity of ETS Transcription Factors | Annual Review of Biochemistry | 2011 | 425 |
| 27 | Snail Induction of Epithelial to Mesenchymal Transition in Tumor Cells Is Accompanied by MUC1 Repression andZEB1 Expression | Journal of Biological Chemistry | 2002 | 407 |
| 28 | Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics | Molecular Therapy | 2013 | 392 |
| 29 | Modulation of Chemical Composition and Other Parameters of the Cell at Different Exponential Growth Rates | EcoSal Plus | 2008 | 368 |
| 30 | Polysaccharide Utilization Loci: Fueling Microbial Communities | Journal of Bacteriology | 2017 | 354 |
| 31 | The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation | Cell | 2013 | 348 |
| 32 | Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures | Biochimica Et Biophysica Acta - Biomembranes | 2001 | 344 |
| 33 | Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility | Nucleic Acid Therapeutics | 2018 | 335 |
| 34 | The structure of human pancreaticα-amylase at 1.8 Å resolution and comparisons with related enzymes | Protein Science | 1995 | 333 |
| 35 | Homologs of Small Nucleolar RNAs in Archaea | Science | 2000 | 324 |
| 36 | Retinal Stimulates ATP Hydrolysis by Purified and Reconstituted ABCR, the Photoreceptor-specific ATP-binding Cassette Transporter Responsible for Stargardt Disease | Journal of Biological Chemistry | 1999 | 322 |
| 37 | On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA | ACS Nano | 2018 | 319 |
| 38 | Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells | Oncogene | 2004 | 315 |
| 39 | Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs | Nature Structural Biology | 2001 | 313 |
| 40 | Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling | PLoS ONE | 2009 | 313 |
| 41 | Crystal structure of enteropathogenic Escherichia coli intimin–receptor complex | Nature | 2000 | 302 |
| 42 | β-Lactam antibiotic resistance: a current structural perspective | Current Opinion in Microbiology | 2005 | 293 |
| 43 | A high-throughput approach for measuring temporal changes in the interactome | Nature Methods | 2012 | 293 |
| 44 | Structural Perspective of Peptidoglycan Biosynthesis and Assembly | Annual Review of Biochemistry | 2012 | 292 |
| 45 | Crystal structure of a bacterial signal peptidase in complex with a β-lactam inhibitor | Nature | 1998 | 291 |
| 46 | Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates | Nature Protocols | 2011 | 291 |
| 47 | RNase E: at the interface of bacterial RNA processing and decay | Nature Reviews Microbiology | 2013 | 290 |
| 48 | EspA, a protein secreted by enteropathogenic Escherichia coli, is required to induce signals in epithelial cells | Molecular Microbiology | 1996 | 280 |
| 49 | Stabilized plasmid-lipid particles: construction and characterization | Gene Therapy | 1999 | 280 |
| 50 | The 220-kDa Rim Protein of Retinal Rod Outer Segments Is a Member of the ABC Transporter Superfamily | Journal of Biological Chemistry | 1997 | 276 |
