| # | Title | Journal | Year | Citations |
|---|
| 1 | New diagnostic criteria for multiple sclerosis: Guidelines for research protocols | Annals of Neurology | 1983 | 7,193 |
| 2 | Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis | Science | 2006 | 5,422 |
| 3 | Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria | Lancet Neurology, The | 2018 | 4,605 |
| 4 | Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS | Neuron | 2011 | 4,176 |
| 5 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration | Lancet Neurology, The | 2013 | 3,919 |
| 6 | Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis | Neurology | 1993 | 1,408 |
| 7 | Defeating Alzheimer's disease and other dementias: a priority for European science and society | Lancet Neurology, The | 2016 | 1,242 |
| 8 | Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes | Nature Genetics | 2018 | 1,124 |
| 9 | Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis withSOD1 mutations | Annals of Neurology | 2007 | 840 |
| 10 | In vivo visualization of myelin water in brain by magnetic resonance | Magnetic Resonance in Medicine | 1994 | 820 |
| 11 | Engraftable human neural stem cells respond to development cues, replace neurons, and express foreign genes | Nature Biotechnology | 1998 | 760 |
| 12 | DOUBLE-BLIND STUDY OF BOTULINUM TOXIN IN SPASMODIC TORTICOLLIS | Lancet, The | 1986 | 727 |
| 13 | MRI in the diagnosis of MS | Neurology | 1988 | 631 |
| 14 | Microglia in health and disease | Journal of Neuroscience Research | 2005 | 601 |
| 15 | Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial | Lancet, The | 2009 | 551 |
| 16 | Clinical trials and late‐stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014 | Journal of Internal Medicine | 2014 | 540 |
| 17 | Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion–diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study | Lancet Neurology, The | 2009 | 526 |
| 18 | Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial | Nature Medicine | 2000 | 506 |
| 19 | TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics | Neuron | 2017 | 493 |
| 20 | Genetics of multiple sclerosis | Lancet Neurology, The | 2004 | 458 |
| 21 | Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D | PLoS Genetics | 2009 | 442 |
| 22 | Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease | Annals of Neurology | 1995 | 421 |
| 23 | AETIOLOGY OF PARKINSON'S DISEASE | Lancet, The | 1983 | 414 |
| 24 | Treatment of spasticity with botulinum toxin: A double-blind study | Annals of Neurology | 1990 | 401 |
| 25 | Epileptic activity in Alzheimer's disease: causes and clinical relevance | Lancet Neurology, The | 2017 | 401 |
| 26 | Incidence and prevalence of multiple sclerosis in Europe: a systematic review | BMC Neurology | 2013 | 392 |
| 27 | Higher 25‐hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis | Annals of Neurology | 2010 | 388 |
| 28 | Stem cell‐based cell therapy in neurological diseases: A review | Journal of Neuroscience Research | 2009 | 387 |
| 29 | Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration | Annals of Neurology | 2003 | 380 |
| 30 | Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease | Neurology | 2010 | 365 |
| 31 | Deep 3D Convolutional Encoder Networks With Shortcuts for Multiscale Feature Integration Applied to Multiple Sclerosis Lesion Segmentation | IEEE Transactions on Medical Imaging | 2016 | 358 |
| 32 | Cytokines, chemokines, and cytokine receptors in human microglia | Journal of Neuroscience Research | 2002 | 318 |
| 33 | Assessment of lesions on magnetic resonance imaging in multiple sclerosis: practical guidelines | Brain | 2019 | 303 |
| 34 | Frontotemporal dementia and its subtypes: a genome-wide association study | Lancet Neurology, The | 2014 | 302 |
| 35 | 2021 MAGNIMS–CMSC–NAIMS consensus recommendations on the use of MRI in patients with multiple sclerosis | Lancet Neurology, The | 2021 | 302 |
| 36 | Nigrostriatal function in humans studied with positron emission tomography | Annals of Neurology | 1989 | 296 |
| 37 | Cholesterol in Alzheimer's disease | Lancet Neurology, The | 2005 | 292 |
| 38 | Post Stroke Pain: Identification, Assessment, and Therapy | Cerebrovascular Diseases | 2015 | 290 |
| 39 | Defining the face processing network: Optimization of the functional localizer in fMRI | Human Brain Mapping | 2009 | 281 |
| 40 | Parkinson's disease: A case-control study of occupational and environmental risk factors | American Journal of Industrial Medicine | 1990 | 274 |
| 41 | The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative | Nature Reviews Neurology | 2016 | 274 |
| 42 | Canadian Stroke Best Practice Recommendations for Acute Stroke Management: Prehospital, Emergency Department, and Acute Inpatient Stroke Care, 6th Edition, Update 2018 | International Journal of Stroke | 2018 | 272 |
| 43 | Erythropoietin and Erythropoietin Receptors in Human CNS Neurons, Astrocytes, Microglia, and Oligodendrocytes Grown in Culture | Journal of Neuropathology and Experimental Neurology | 2001 | 270 |
| 44 | A proposal for new diagnostic criteria for ALS | Clinical Neurophysiology | 2020 | 268 |
| 45 | Myelin-oligodendrocyte glycoprotein antibody-associated disease | Lancet Neurology, The | 2021 | 261 |
| 46 | World‐Wide FINGERS Network: A global approach to risk reduction and prevention of dementia | Alzheimer's and Dementia | 2020 | 257 |
| 47 | Parent-of-origin effect in multiple sclerosis: observations in half-siblings | Lancet, The | 2004 | 249 |
| 48 | ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, AND MOTONEURONE DISEASE: ABIOTROPIC INTERACTION BETWEEN AGEING AND ENVIRONMENT? | Lancet, The | 1986 | 247 |
| 49 | A Pilot Study on the Use of Botulinum Toxin in Spasmodic Torticollis | Canadian Journal of Neurological Sciences | 1985 | 237 |
| 50 | Complement and cytokine gene expression in cultured microglia derived from postmortem human brains | Journal of Neuroscience Research | 1995 | 233 |
