| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains | Neurology | 1988 | 2,543 |
| 3 | Histochemical mapping of nitric oxide synthase in the rat brain | Neuroscience | 1992 | 1,901 |
| 4 | Consensus statement on concussion in sport: the 4th International Conference on Concussion in Sport held in Zurich, November 2012 | British Journal of Sports Medicine | 2013 | 1,744 |
| 5 | Neuronal NADPH diaphorase is a nitric oxide synthase. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 1,715 |
| 6 | Development of cognitive control and executive functions from 4 to 13 years: Evidence from manipulations of memory, inhibition, and task switching | Neuropsychologia | 2006 | 1,604 |
| 7 | Plasticity during stroke recovery: from synapse to behaviour | Nature Reviews Neuroscience | 2009 | 1,509 |
| 8 | Robust dimensions of anxiety sensitivity: Development and initial validation of the Anxiety Sensitivity Index-3. | Psychological Assessment | 2007 | 1,384 |
| 9 | Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease | Neurology | 1996 | 1,342 |
| 10 | Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder | Bipolar Disorders | 2018 | 1,079 |
| 11 | The central cholinergic system studied by choline acetyltransferase immunohistochemistry in the cat | Journal of Comparative Neurology | 1981 | 968 |
| 12 | Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease | Journal of Neuroimmunology | 1989 | 844 |
| 13 | Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids | Nature | 1976 | 828 |
| 14 | The organization and some projections of cholinergic neurons of the mammalian forebrain | Brain Research Reviews | 1982 | 818 |
| 15 | Calcium transients in astrocyte endfeet cause cerebrovascular constrictions | Nature | 2004 | 789 |
| 16 | Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR | Neuroscience Letters | 1987 | 781 |
| 17 | Heritability of the Big Five Personality Dimensions and Their Facets: A Twin Study | Journal of Personality | 1996 | 773 |
| 18 | Development and initial validation of the COVID Stress Scales | Journal of Anxiety Disorders | 2020 | 759 |
| 19 | Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder | Canadian Journal of Psychiatry | 2016 | 746 |
| 20 | Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013 | Bipolar Disorders | 2013 | 740 |
| 21 | Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial | Lancet, The | 2018 | 706 |
| 22 | On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine | Pharmacology Biochemistry and Behavior | 1977 | 685 |
| 23 | Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens | Pharmacology Biochemistry and Behavior | 1980 | 681 |
| 24 | The borderline diagnosis I: psychopathology, comorbidity, and personaltity structure | Biological Psychiatry | 2002 | 678 |
| 25 | Limbic abnormalities in affective processing by criminal psychopaths as revealed by functional magnetic resonance imaging | Biological Psychiatry | 2001 | 676 |
| 26 | Coronaphobia: Fear and the 2019-nCoV outbreak | Journal of Anxiety Disorders | 2020 | 672 |
| 27 | Demonstration of a unique population of neurons with NADPH-diaphorase histochemistry | Journal of Neuroscience Methods | 1983 | 663 |
| 28 | Conclusions about interventions, programs, and approaches for improving executive functions that appear justified and those that, despite much hype, do not | Developmental Cognitive Neuroscience | 2016 | 655 |
| 29 | Brain metabolism dictates the polarity of astrocyte control over arterioles | Nature | 2008 | 642 |
| 30 | The nucleus basalis magnocellularis: The origin of a cholinergic projection to the neocortex of the rat | Neuroscience | 1980 | 603 |
| 31 | Cleavage at the Caspase-6 Site Is Required for Neuronal Dysfunction and Degeneration Due to Mutant Huntingtin | Cell | 2006 | 600 |
| 32 | Afferent connections of the laterodorsal and the pedunculopontine tegmental nuclei in the rat: A retro- and antero-grade transport and immunohistochemical study | Journal of Comparative Neurology | 1992 | 569 |
| 33 | Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders | BMC Psychiatry | 2014 | 569 |
| 34 | Outcome from mild traumatic brain injury | Current Opinion in Psychiatry | 2005 | 565 |
| 35 | Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence | Trends in Neurosciences | 1991 | 564 |
| 36 | Activities and Programs That Improve Children’s Executive Functions | Current Directions in Psychological Science | 2012 | 557 |
| 37 | Phenotypic and Genetic Structure of Traits Delineating Personality Disorder | Archives of General Psychiatry | 1998 | 556 |
| 38 | Dynamic functional reorganization of the motor execution network after stroke | Brain | 2010 | 547 |
| 39 | Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009 | Bipolar Disorders | 2009 | 545 |
| 40 | Event-related fMRI study of response inhibition | Human Brain Mapping | 2001 | 543 |
| 41 | Updated Energy Budgets for Neural Computation in the Neocortex and Cerebellum | Journal of Cerebral Blood Flow and Metabolism | 2012 | 542 |
| 42 | PTSD and the Experience of Pain: Research and Clinical Implications of Shared Vulnerability and Mutual Maintenance Models | Canadian Journal of Psychiatry | 2002 | 538 |
| 43 | Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 529 |
| 44 | Rate of cell death in parkinsonism indicates active neuropathological process | Annals of Neurology | 1988 | 522 |
| 45 | Generation of C-Reactive Protein and Complement Components in Atherosclerotic Plaques | American Journal of Pathology | 2001 | 522 |
| 46 | How health anxiety influences responses to viral outbreaks like COVID-19: What all decision-makers, health authorities, and health care professionals need to know | Journal of Anxiety Disorders | 2020 | 522 |
| 47 | Comparative efficacy of treatments for post-traumatic stress disorder: a meta-analysis | | 1998 | 513 |
| 48 | Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation | Nature | 2008 | 508 |
| 49 | Neuropsychological functioning in euthymic bipolar disorder: a meta‐analysis | Acta Psychiatrica Scandinavica | 2007 | 500 |
| 50 | A glutamatergic corticostriatal path? | Brain Research | 1977 | 491 |
