| # | Title | Journal | Year | Citations |
|---|
| 1 | Eosinophilic Esophagitis in Children and Adults: A Systematic Review and Consensus Recommendations for Diagnosis and Treatment | Gastroenterology | 2007 | 1,547 |
| 2 | Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) | Journal of Pediatric Gastroenterology and Nutrition | 2009 | 638 |
| 3 | Regulated Virulence Controls the Ability of a Pathogen to Compete with the Gut Microbiota | Science | 2012 | 546 |
| 4 | ACG and CAG Clinical Guideline: Management of Dyspepsia | American Journal of Gastroenterology | 2017 | 431 |
| 5 | Ledipasvir and sofosbuvir plus ribavirin in patients with genotype 1 or 4 hepatitis C virus infection and advanced liver disease: a multicentre, open-label, randomised, phase 2 trial | Lancet Infectious Diseases, The | 2016 | 402 |
| 6 | Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens | Cell Host and Microbe | 2014 | 371 |
| 7 | Dissemination of invasiveSalmonellavia bacterial-induced extrusion of mucosal epithelia | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 354 |
| 8 | Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial Assessing the Efficacy and Safety of Proton Pump Inhibitor Lansoprazole in Infants with Symptoms of Gastroesophageal Reflux Disease | Journal of Pediatrics | 2009 | 334 |
| 9 | Clinical Practice Guidelines for the Use of Video Capsule Endoscopy | Gastroenterology | 2017 | 306 |
| 10 | ERCP-Related Perforations: Risk Factors and Management | Endoscopy | 2002 | 288 |
| 11 | Analysis of causes of death in liver transplant recipients who survived more than 3 years | Liver Transplantation | 2001 | 252 |
| 12 | SPARC in cancer biology: Its role in cancer progression and potential for therapy | Drug Resistance Updates | 2008 | 199 |
| 13 | Infliximab and other immunomodulating drugs in patients with inflammatory bowel disease and the risk of serious bacterial infections | Alimentary Pharmacology and Therapeutics | 2009 | 196 |
| 14 | Escherichia coli Pathobionts Associated with Inflammatory Bowel Disease | Clinical Microbiology Reviews | 2019 | 194 |
| 15 | The antibacterial properties of isothiocyanates | Microbiology (United Kingdom) | 2015 | 191 |
| 16 | Host Susceptibility to the Attaching and Effacing Bacterial Pathogen Citrobacter rodentium | Infection and Immunity | 2003 | 178 |
| 17 | MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitis | Cellular Microbiology | 2008 | 168 |
| 18 | Prevalence of Anxiety and Depression in Patients with Inflammatory Bowel Disease | Canadian Journal of Gastroenterology and Hepatology | 2017 | 158 |
| 19 | American Gastroenterological Association Institute Guideline on the Diagnosis and Management of Lynch Syndrome | Gastroenterology | 2015 | 149 |
| 20 | Generation and Characterization of Murine Alternatively Activated Macrophages | Methods in Molecular Biology | 2013 | 143 |
| 21 | Toll-Like Receptor 4 Contributes to Colitis Development but Not to Host Defense during Citrobacter rodentium Infection in Mice | Infection and Immunity | 2006 | 141 |
| 22 | Clinical, endoscopic and radiographic outcomes with ustekinumab in medically‐refractory Crohn's disease: real world experience from a multicentre cohort | Alimentary Pharmacology and Therapeutics | 2017 | 141 |
| 23 | Characteristics of Children Receiving Proton Pump Inhibitors Continuously for Up to 11 Years Duration | Journal of Pediatrics | 2007 | 136 |
| 24 | Colonic microbiota alters host susceptibility to infectious colitis by modulating inflammation, redox status, and ion transporter gene expression | American Journal of Physiology - Renal Physiology | 2011 | 134 |
| 25 | Humoral Immunity in the Gut Selectively Targets Phenotypically Virulent Attaching-and-Effacing Bacteria for Intraluminal Elimination | Cell Host and Microbe | 2015 | 132 |
| 26 | Milk Fat Globule Membrane Supplementation in Formula Modulates the Neonatal Gut Microbiome and Normalizes Intestinal Development | Scientific Reports | 2017 | 132 |
| 27 | Chronic Enteric Salmonella Infection in Mice Leads to Severe and Persistent Intestinal Fibrosis | Gastroenterology | 2008 | 130 |
| 28 | Genome-wide expression analysis of therapy-resistant tumors reveals SPARC as a novel target for cancer therapy | Journal of Clinical Investigation | 2005 | 125 |
| 29 | Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis | Cellular Microbiology | 2007 | 116 |
| 30 | Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in NOD mice | Diabetologia | 2010 | 114 |
| 31 | Commonly Used Preparations for Colonoscopy: Efficacy, Tolerability and Safety – A Canadian Association of Gastroenterology Position Paper | Canadian Journal of Gastroenterology & Hepatology | 2006 | 112 |
| 32 | Factors influencing patient satisfaction when undergoing endoscopic procedures | Gastrointestinal Endoscopy | 2009 | 107 |
| 33 | A Novel Mouse Model of Campylobacter jejuni Gastroenteritis Reveals Key Pro-inflammatory and Tissue Protective Roles for Toll-like Receptor Signaling during Infection | PLoS Pathogens | 2014 | 107 |
| 34 | SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2′deoxycytidine to increase SPARC expression and improve therapy response | British Journal of Cancer | 2008 | 100 |
| 35 | High Prevalence of Celiac Disease in Patients with Type 1 Diabetes Detected by Antibodies to Endomysium and Tissue Transglutaminase | Canadian Journal of Gastroenterology & Hepatology | 2001 | 94 |
| 36 | Long-term Maintenance of Clinical, Endoscopic, and Radiographic Response to Ustekinumab in Moderate-to-Severe Crohnʼs Disease | Inflammatory Bowel Diseases | 2017 | 94 |
| 37 | The risks of post-operative complications following pre-operative infliximab therapy for Crohn's disease in patients undergoing abdominal surgery: A systematic review and meta-analysis | Journal of Crohn's and Colitis | 2013 | 92 |
| 38 | The Population Level Cascade of Care for Hepatitis C in British Columbia, Canada: The BC Hepatitis Testers Cohort (BC-HTC) | EBioMedicine | 2016 | 89 |
| 39 | The Crohn’s Disease Activity Index, Its Derivatives and the Inflammatory Bowel Disease Questionnaire: A Review of Instruments to Assess in Crohn’s Disease | Canadian Journal of Gastroenterology & Hepatology | 1999 | 88 |
| 40 | Periostin induction in tumor cell line explants and inhibition of in vitro cell growth by anti-periostin antibodies | Carcinogenesis | 2005 | 88 |
| 41 | Attaching and Effacing Bacterial Effector NleC Suppresses Epithelial Inflammatory Responses by Inhibiting NF-κB and p38 Mitogen-Activated Protein Kinase Activation | Infection and Immunity | 2011 | 85 |
| 42 | Machine learning in GI endoscopy: practical guidance in how to interpret a novel field | Gut | 2020 | 85 |
| 43 | Efficacy and Safety of Mycophenolate Mofetil and Tacrolimus as Second-line Therapy for Patients With Autoimmune Hepatitis | Clinical Gastroenterology and Hepatology | 2017 | 84 |
| 44 | Alternative activation of macrophages by IL‐4 requires SHIP degradation | European Journal of Immunology | 2011 | 82 |
| 45 | Long-term effect of sustained virological response on hepatocellular carcinoma in patients with hepatitis C in Canada | Journal of Hepatology | 2017 | 82 |
| 46 | Safety and Efficacy of Hemospray®in Upper Gastrointestinal Bleeding | Canadian Journal of Gastroenterology and Hepatology | 2014 | 79 |
| 47 | Phosphatidylinositol 3-Kinase Is Involved in the Induction of Macrophage Growth by Oxidized Low Density Lipoprotein | Journal of Biological Chemistry | 1998 | 78 |
| 48 | When trainees reach competency in performing ERCP: a systematic review | Gastrointestinal Endoscopy | 2015 | 78 |
| 49 | SIGIRR, a Negative Regulator of TLR/IL-1R Signalling Promotes Microbiota Dependent Resistance to Colonization by Enteric Bacterial Pathogens | PLoS Pathogens | 2013 | 77 |
| 50 | Post–liver transplantation diabetes mellitus: An association with hepatitis C | Liver Transplantation | 2002 | 76 |
