| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 2 | Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter-Related Infection: 2009 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2009 | 2,904 |
| 3 | Guidelines for the Prevention of Intravascular Catheter-related Infections | Clinical Infectious Diseases | 2011 | 2,242 |
| 4 | The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics | Nature Reviews Drug Discovery | 2008 | 2,084 |
| 5 | Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation | Nature Medicine | 2003 | 1,606 |
| 6 | Guidelines for the Management of Intravascular Catheter-Related Infections | Clinical Infectious Diseases | 2001 | 1,354 |
| 7 | Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014 | JAMA - Journal of the American Medical Association | 2017 | 1,180 |
| 8 | Pulmonary Hypertension as a Risk Factor for Death in Patients with Sickle Cell Disease | New England Journal of Medicine | 2004 | 1,172 |
| 9 | The Cardiovascular Response of Normal Humans to the Administration of Endotoxin | New England Journal of Medicine | 1989 | 1,107 |
| 10 | Guidelines for the prevention of intravascular catheter-related infections | American Journal of Infection Control | 2011 | 874 |
| 11 | Bundled care for septic shock: An analysis of clinical trials* | Critical Care Medicine | 2010 | 854 |
| 12 | Deconstructing sickle cell disease: Reappraisal of the role of hemolysis in the development of clinical subphenotypes | Blood Reviews | 2007 | 728 |
| 13 | Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells | Blood | 2003 | 675 |
| 14 | Endotoxemia in Human Septic Shock | Chest | 1991 | 640 |
| 15 | Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock. | Journal of Experimental Medicine | 1989 | 556 |
| 16 | Cell-Free Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death | JAMA - Journal of the American Medical Association | 2008 | 552 |
| 17 | HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies | Nature Medicine | 1997 | 501 |
| 18 | Serial cardiovascular variables in survivors and nonsurvivors of human septic shock | Critical Care Medicine | 1987 | 499 |
| 19 | Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer | Journal of Experimental Medicine | 2007 | 492 |
| 20 | Promotion and Subsequent Inhibition of Plasminogen Activation after Administration of Intravenous Endotoxin to Normal Subjects | New England Journal of Medicine | 1989 | 488 |
| 21 | Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents. | Journal of Experimental Medicine | 1991 | 459 |
| 22 | Subglottic secretion drainage for preventing ventilator-associated pneumonia: A meta-analysis | American Journal of Medicine | 2005 | 423 |
| 23 | Meta-Analysis of Acute Lung Injury and Acute Respiratory Distress Syndrome Trials Testing Low Tidal Volumes | American Journal of Respiratory and Critical Care Medicine | 2002 | 420 |
| 24 | Selected Treatment Strategies for Septic Shock Based on Proposed Mechanisms of Pathogenesis | Annals of Internal Medicine | 1994 | 418 |
| 25 | SARS-Coronavirus Open Reading Frame-9b Suppresses Innate Immunity by Targeting Mitochondria and the MAVS/TRAF3/TRAF6 Signalosome | Journal of Immunology | 2014 | 410 |
| 26 | Summary of Recommendations: Guidelines for the Prevention of Intravascular Catheter-related Infections | Clinical Infectious Diseases | 2011 | 407 |
| 27 | Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 393 |
| 28 | Right Ventricular Dysfunction and Dilatation, Similar to Left Ventricular Changes, Characterize the Cardiac Depression of Septic Shock in Humans | Chest | 1990 | 392 |
| 29 | Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 376 |
| 30 | Adoptively transferred effector cells derived from naïve rather than central memory CD8 + T cells mediate superior antitumor immunity | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 348 |
| 31 | Risk and the Efficacy of Antiinflammatory Agents | American Journal of Respiratory and Critical Care Medicine | 2002 | 344 |
| 32 | Transmission of HTLV-III infection from human plasma to chimpanzees: an animal model for AIDS | Science | 1984 | 341 |
| 33 | Bacterial Coinfection in Influenza | JAMA - Journal of the American Medical Association | 2013 | 339 |
| 34 | The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation | Free Radical Biology and Medicine | 2004 | 332 |
| 35 | New insights into the biology of the acute phase response | Journal of Clinical Immunology | 1999 | 329 |
| 36 | Depressed Left Ventricular Performance | Chest | 1988 | 321 |
| 37 | Transfusion of older stored blood and risk of death: a meta‐analysis | Transfusion | 2012 | 315 |
| 38 | Sensitivity in Detection of Antibodies to Nucleocapsid and Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus 2 in Patients With Coronavirus Disease 2019 | Journal of Infectious Diseases | 2020 | 314 |
| 39 | Clonally expanded CD4 + T cells can produce infectious HIV-1 in vivo | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 302 |
| 40 | Multiplex bead array assays for detection of soluble cytokines: Comparisons of sensitivity and quantitative values among kits from multiple manufacturers | Cytometry | 2004 | 293 |
| 41 | Detection of circulating endothelial cells and endothelial progenitor cells by flow cytometry | Cytometry Part B - Clinical Cytometry | 2005 | 277 |
| 42 | The Pathogenesis of Ebola Virus Disease | Annual Review of Pathology: Mechanisms of Disease | 2017 | 266 |
| 43 | Diastolic Dysfunction Is an Independent Risk Factor for Death in Patients With Sickle Cell Disease | Journal of the American College of Cardiology | 2007 | 265 |
| 44 | Sofosbuvir and Ribavirin for Hepatitis C Genotype 1 in Patients With Unfavorable Treatment Characteristics | JAMA - Journal of the American Medical Association | 2013 | 265 |
| 45 | Excess Deaths Associated With Tigecycline After Approval Based on Noninferiority Trials | Clinical Infectious Diseases | 2012 | 260 |
| 46 | Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator | Nature Medicine | 2004 | 259 |
| 47 | The functional nitrite reductase activity of the heme-globins | Blood | 2008 | 253 |
| 48 | Response of man to endotoxin | Immunobiology | 1993 | 252 |
| 49 | Idiopathic CD4+ lymphocytopenia: natural history and prognostic factors | Blood | 2008 | 243 |
| 50 | Divergent Nitric Oxide Bioavailability in Men and Women With Sickle Cell Disease | Circulation | 2003 | 236 |
