| # | Title | Journal | Year | Citations |
|---|
| 1 | Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects | Nature Medicine | 1995 | 3,427 |
| 2 | Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia | Journal of Clinical Endocrinology and Metabolism | 2001 | 3,039 |
| 3 | Circulating Ghrelin Levels Are Decreased in Human Obesity | Diabetes | 2001 | 1,786 |
| 4 | The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus | Journal of Clinical Investigation | 1999 | 1,559 |
| 5 | Skeletal muscle metabolism is a major determinant of resting energy expenditure. | Journal of Clinical Investigation | 1990 | 729 |
| 6 | High White Blood Cell Count Is Associated With a Worsening of Insulin Sensitivity and Predicts the Development of Type 2 Diabetes | Diabetes | 2002 | 672 |
| 7 | Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts Type II diabetes independent of insulin resistance | Diabetologia | 2000 | 659 |
| 8 | High Alanine Aminotransferase Is Associated With Decreased Hepatic Insulin Sensitivity and Predicts the Development of Type 2 Diabetes | Diabetes | 2002 | 615 |
| 9 | Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 549 |
| 10 | Circulating Interleukin‐6 in Relation to Adiposity, Insulin Action, and Insulin Secretion | Obesity | 2001 | 507 |
| 11 | Plasma Adiponectin Concentration Is Associated With Skeletal Muscle Insulin Receptor Tyrosine Phosphorylation, and Low Plasma Concentration Precedes a Decrease in Whole-Body Insulin Sensitivity in Humans | Diabetes | 2002 | 491 |
| 12 | The role of impaired early insulin secretion in the pathogenesis of Type II diabetes mellitus | Diabetologia | 2001 | 367 |
| 13 | Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ | American Journal of Physiology - Endocrinology and Metabolism | 1990 | 346 |
| 14 | A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM | Diabetologia | 1995 | 344 |
| 15 | Identification of Individuals With Insulin Resistance Using Routine Clinical Measurements | Diabetes | 2005 | 324 |
| 16 | Insulin Resistance and Insulin Secretory Dysfunction Are Independent Predictors of Worsening of Glucose Tolerance During Each Stage of Type 2 Diabetes Development | Diabetes Care | 2001 | 303 |
| 17 | Insulin resistance associated with lower rates of weight gain in Pima Indians. | Journal of Clinical Investigation | 1991 | 295 |
| 18 | Differential brain responses to satiation in obese and lean men | Diabetes | 2000 | 268 |
| 19 | Plasma Adiponectin Concentrations in Children: Relationships with Obesity and Insulinemia | Journal of Clinical Endocrinology and Metabolism | 2002 | 267 |
| 20 | Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians | Human Molecular Genetics | 1998 | 261 |
| 21 | Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance | Diabetes | 1999 | 260 |
| 22 | Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain. | Journal of Clinical Investigation | 1993 | 258 |
| 23 | A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia | Diabetes | 2000 | 256 |
| 24 | Relatively low plasma leptin concentrations precede weight gain in Pima Indians | Nature Medicine | 1997 | 238 |
| 25 | Effects of glucocorticoids on energy metabolism and food intake in humans | American Journal of Physiology - Endocrinology and Metabolism | 1996 | 230 |
| 26 | Fasting Hyperinsulinemia Is a Predictor of Increased Body Weight Gain and Obesity in Pima Indian Children | Diabetes | 1997 | 228 |
| 27 | Aging and energy expenditure | American Journal of Clinical Nutrition | 1991 | 205 |
| 28 | Pathophysiology of obesity | Lancet, The | 1992 | 204 |
| 29 | Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians | Atherosclerosis | 2002 | 198 |
| 30 | Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans | Diabetes | 1998 | 185 |
| 31 | Obesity and insulin resistance: Lessons learned from the Pima indians | Diabetes/metabolism Reviews | 1988 | 184 |
| 32 | Effect of Satiation on Brain Activity in Obese and Lean Women | Obesity | 2001 | 184 |
| 33 | Lower sedentary metabolic rate in women compared with men. | Journal of Clinical Investigation | 1992 | 178 |
| 34 | Cloning and Characterization of on 7q21.3 Encoding a Fourth Pyruvate Dehydrogenase Kinase Isoenzyme in Human | Journal of Biological Chemistry | 1996 | 167 |
| 35 | Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence | Gene | 1998 | 163 |
| 36 | Determinants of energy expenditure and fuel utilization in man: effects of body composition, age, sex, ethnicity and glucose tolerance in 916 subjects | International Journal of Obesity | 1999 | 160 |
| 37 | Taste preferences and body weight changes in an obesity-prone population | American Journal of Clinical Nutrition | 2004 | 160 |
| 38 | Neuroimaging and Obesity | Annals of the New York Academy of Sciences | 2002 | 159 |
| 39 | Deterioration in Carbohydrate Metabolism and Lipoprotein Changes Induced by Modern, High Fat Diet in Pima Indians and Caucasians | Journal of Clinical Endocrinology and Metabolism | 1991 | 158 |
| 40 | The interleukin-6 (−174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians | Human Genetics | 2003 | 157 |
| 41 | Energy metabolism after 2 y of energy restriction: the Biosphere 2 experiment | American Journal of Clinical Nutrition | 2000 | 156 |
| 42 | Body weight gain in free-living Pima Indians: effect of energy intake vs expenditure | International Journal of Obesity | 2003 | 148 |
| 43 | Determinants of total daily energy expenditure: variability in physical activity | American Journal of Clinical Nutrition | 1994 | 146 |
| 44 | Linkage of Chromosomal Markers on 4q With a Putative Gene Determining Maximal Insulin Action in Pima Indians | Diabetes | 1993 | 144 |
| 45 | Assessing Risk Factors for Obesity Between Childhood and Adolescence: II. Energy Metabolism and Physical Activity | Pediatrics | 2002 | 143 |
| 46 | High Serum Resistin Is Associated With an Increase in Adiposity But Not a Worsening of Insulin Resistance in Pima Indians | Diabetes | 2004 | 143 |
| 47 | Higher sedentary energy expenditure in patients with Huntington's disease | Annals of Neurology | 2000 | 138 |
| 48 | Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men. | Journal of Clinical Investigation | 1994 | 133 |
| 49 | Distribution of In Vivo Insulin Action in Pima Indians as Mixture of Three Normal Distributions | Diabetes | 1989 | 129 |
| 50 | Energy metabolism in weight-stable postobese individuals | American Journal of Clinical Nutrition | 1995 | 126 |
