| # | Title | Journal | Year | Citations |
|---|
|
| 1 | NCBI GEO: archive for functional genomics data sets—update | Nucleic Acids Research | 2012 | 7,638 |
| 2 | Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose | Proceedings of the National Academy of Sciences of the United States of America | 1972 | 7,137 |
| 3 | The Genome Sequence of Drosophila melanogaster | Science | 2000 | 5,617 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,789 |
| 5 | A rapid method for the isolation of functional thymus‐derived murine lymphocytes | European Journal of Immunology | 1973 | 4,373 |
| 6 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,992 |
| 7 | A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD | Neuron | 2011 | 3,944 |
| 8 | Tissue microarrays for high-throughput molecular profiling of tumor specimens | Nature Medicine | 1998 | 3,683 |
| 9 | Patterns of Cancer Incidence, Mortality, and Prevalence Across Five Continents: Defining Priorities to Reduce Cancer Disparities in Different Geographic Regions of the World | Journal of Clinical Oncology | 2006 | 3,174 |
| 10 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,158 |
| 11 | A Protein Binding Assay for Adenosine 3′:5′-Cyclic Monophosphate | Proceedings of the National Academy of Sciences of the United States of America | 1970 | 3,129 |
| 12 | Next-generation genotype imputation service and methods | Nature Genetics | 2016 | 3,070 |
| 13 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,676 |
| 14 | A reference panel of 64,976 haplotypes for genotype imputation | Nature Genetics | 2016 | 2,559 |
| 15 | Strong Association of De Novo Copy Number Mutations with Autism | Science | 2007 | 2,526 |
| 16 | The skin microbiome | Nature Reviews Microbiology | 2011 | 2,492 |
| 17 | Ovarian cancer statistics, 2018 | Ca-A Cancer Journal for Clinicians | 2018 | 2,435 |
| 18 | The Sequence Read Archive | Nucleic Acids Research | 2011 | 2,430 |
| 19 | LocusZoom: regional visualization of genome-wide association scan results | Bioinformatics | 2010 | 2,412 |
| 20 | Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks | Nature Medicine | 2001 | 2,375 |
| 21 | GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor | Bioinformatics | 2007 | 2,265 |
| 22 | Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease | Neuron | 2004 | 2,231 |
| 23 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 2,145 |
| 24 | A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases | Nature Medicine | 2015 | 2,079 |
| 25 | The Transcriptional Program in the Response of Human Fibroblasts to Serum | Science | 1999 | 1,908 |
| 26 | Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences | Annual Review of Biophysics | 2008 | 1,872 |
| 27 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,855 |
| 28 | Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells | Nature Immunology | 2010 | 1,853 |
| 29 | Osteosarcoma incidence and survival rates from 1973 to 2004 | Cancer | 2009 | 1,834 |
| 30 | Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma | Thyroid | 2015 | 1,832 |
| 31 | Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease | New England Journal of Medicine | 2009 | 1,812 |
| 32 | Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 1,808 |
| 33 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,804 |
| 34 | Genome-wide association study reveals genetic risk underlying Parkinson's disease | Nature Genetics | 2009 | 1,783 |
| 35 | Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors | Cancer Research | 2012 | 1,747 |
| 36 | Gene-Expression Profiles in Hereditary Breast Cancer | New England Journal of Medicine | 2001 | 1,676 |
| 37 | Assessing the Probability That a Positive Report is False: An Approach for Molecular Epidemiology Studies | Journal of the National Cancer Institute | 2004 | 1,583 |
| 38 | The complete sequence of a human genome | Science | 2022 | 1,565 |
| 39 | High frequency of BRAF mutations in nevi | Nature Genetics | 2003 | 1,563 |
| 40 | Expression profiling using cDNA microarrays | Nature Genetics | 1999 | 1,531 |
| 41 | The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus | ELife | 2015 | 1,513 |
| 42 | 53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks | Cell | 2010 | 1,451 |
| 43 | Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001 | Blood | 2006 | 1,425 |
| 44 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,389 |
| 45 | A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer | Nature Genetics | 2007 | 1,375 |
| 46 | Recent progress in the biology and physiology of sirtuins | Nature | 2009 | 1,366 |
| 47 | RNA Codewords and Protein Synthesis: The Effect of Trinucleotides upon the Binding of sRNA to Ribosomes | Science | 1964 | 1,357 |
| 48 | A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis | American Journal of Human Genetics | 2004 | 1,326 |
| 49 | The Influence of Macromolecular Crowding and Macromolecular Confinement on Biochemical Reactions in Physiological Media | Journal of Biological Chemistry | 2001 | 1,285 |
| 50 | TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 1,229 |
