| # | Title | Journal | Year | Citations |
|---|
| 1 | Socioeconomic Inequalities in Depression: A Meta-Analysis | American Journal of Epidemiology | 2003 | 1,875 |
| 2 | Triggering and amplifying pathways of regulation of insulin secretion by glucose | Diabetes | 2000 | 1,039 |
| 3 | Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome | Molecular and Cellular Endocrinology | 2010 | 856 |
| 4 | Pancreatic β‐cell mass in European subjects with type 2 diabetes | Diabetes, Obesity and Metabolism | 2008 | 661 |
| 5 | Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells. | Journal of Clinical Investigation | 1992 | 430 |
| 6 | Mechanisms and Physiological Significance of the Cholinergic Control of Pancreatic β-Cell Function | Endocrine Reviews | 2001 | 429 |
| 7 | Lung Epithelium–specific Proteins | American Journal of Respiratory and Critical Care Medicine | 1999 | 422 |
| 8 | Regulation of insulin secretion: a matter of phase control and amplitude modulation | Diabetologia | 2009 | 411 |
| 9 | Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets. | Journal of Clinical Investigation | 1997 | 346 |
| 10 | Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior | Nature Communications | 2017 | 329 |
| 11 | Loss of Connexin36 Channels Alters -Cell Coupling, Islet Synchronization of Glucose-Induced Ca2+ and Insulin Oscillations, and Basal Insulin Release | Diabetes | 2005 | 328 |
| 12 | Density of Demodex folliculorum in rosacea: a case-control study using standardized skin-surface biopsy | British Journal of Dermatology | 1993 | 317 |
| 13 | Cellular Biology and Biochemical Mechanism of Bone Resorption | Clinical Orthopaedics and Related Research | 1988 | 313 |
| 14 | Secretion of Adiponectin and Regulation of apM1 Gene Expression in Human Visceral Adipose Tissue | Biochemical and Biophysical Research Communications | 2001 | 308 |
| 15 | Insulin resistance in hepatocytes and sinusoidal liver cells: Mechanisms and consequences | Journal of Hepatology | 2007 | 299 |
| 16 | Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 294 |
| 17 | Oscillations of secretion driven by oscillations of cytoplasmic Ca2+ as evidences in single pancreatic islets. | Journal of Biological Chemistry | 1993 | 291 |
| 18 | Renal and Neurologic Effects of Cadmium, Lead, Mercury, and Arsenic in Children: Evidence of Early Effects and Multiple Interactions at Environmental Exposure Levels | Environmental Health Perspectives | 2006 | 280 |
| 19 | Epidemiological survey among workers exposed to manganese: Effects on lung, central nervous system, and some biological indices | American Journal of Industrial Medicine | 1987 | 257 |
| 20 | Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells. | Journal of Clinical Investigation | 1993 | 231 |
| 21 | Oscillations of secretion driven by oscillations of cytoplasmic Ca2+ as evidences in single pancreatic islets | Journal of Biological Chemistry | 1993 | 216 |
| 22 | Lung hyperpermeability and asthma prevalence in schoolchildren: unexpected associations with the attendance at indoor chlorinated swimming pools | Occupational and Environmental Medicine | 2003 | 211 |
| 23 | Clara cell secretory protein (CC16): characteristics and perspectives as lung peripheral biomarker | Clinical and Experimental Allergy | 2000 | 205 |
| 24 | Induction of Adiponectin in Skeletal Muscle by Inflammatory Cytokines:in Vivoandin VitroStudies | Endocrinology | 2004 | 200 |
| 25 | Kupffer Cells Mediate Leptin-Induced Liver Fibrosis | Gastroenterology | 2009 | 196 |
| 26 | Study of inorganic arsenic methylation by rat liver in vitro: relevance for the interpretation of observations in man | Archives of Toxicology | 1985 | 194 |
| 27 | Nutrient Control of Insulin Secretion in Isolated Normal Human Islets | Diabetes | 2006 | 192 |
| 28 | Mechanisms of the Stimulation of Insulin Release by Saturated Fatty Acids: A Study of Palmitate Effects in Mouse β-cells | Diabetes | 1994 | 191 |
| 29 | Loss of high-frequency glucose-induced Ca 2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5 −/− mice | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 187 |
| 30 | Established diet-induced obesity in female rats leads to offspring hyperphagia, adiposity and insulin resistance | Diabetologia | 2009 | 186 |
| 31 | Wheelchair Propulsion Biomechanics | Sports Medicine | 2001 | 185 |
| 32 | Effects of vanadium complexes with organic ligands on glucose metabolism: a comparison study in diabetic rats | British Journal of Pharmacology | 1999 | 184 |
| 33 | Elevation of total serum IgE in rats following helminth parasite infection | Nature | 1974 | 181 |
| 34 | Mycobacterium ulcerans infection: control, diagnosis, and treatment | Lancet Infectious Diseases, The | 2006 | 180 |
| 35 | Functional food concept and its application to prebiotics | Digestive and Liver Disease | 2002 | 175 |
| 36 | Adipokines oversecreted by omental adipose tissue in human obesity | American Journal of Physiology - Endocrinology and Metabolism | 2007 | 173 |
| 37 | Clara Cell Secretory Protein (CC16): Features as a Peripheral Lung Biomarker | Annals of the New York Academy of Sciences | 2000 | 172 |
| 38 | Influence of membrane potential changes on cytoplasmic Ca2+ concentration in an electrically excitable cell, the insulin-secreting pancreatic B-cell | Journal of Biological Chemistry | 1992 | 170 |
| 39 | Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation | Apoptosis: an International Journal on Programmed Cell Death | 2008 | 167 |
| 40 | Electron paramagnetic resonance as a tool to evaluate human ovarian tissue reoxygenation after xenografting | Fertility and Sterility | 2009 | 160 |
| 41 | Pancreatic alpha cell mass in European subjects with type 2 diabetes | Diabetologia | 2011 | 160 |
| 42 | Interplay between cytoplasmic Ca2+ and the ATP/ADP ratio: a feedback control mechanism in mouse pancreatic islets | Biochemical Journal | 1998 | 159 |
| 43 | Beyond metaphor: contrasting mechanisms of social and physical pain | Trends in Cognitive Sciences | 2013 | 156 |
| 44 | Further evidence validating adjuvant arthritis as an experimental model of chronic pain in the rat | Life Sciences | 1982 | 154 |
| 45 | Long Term Improvement of Glucose Homeostasis by Vanadate Treatment in Diabetic Rats | Endocrinology | 1988 | 154 |
| 46 | The role of vanadium in the management of diabetes | Trends in Pharmacological Sciences | 1995 | 152 |
| 47 | New developments in the understanding of immunology in silicosis | Current Opinion in Allergy and Clinical Immunology | 2007 | 152 |
| 48 | Control Mechanisms of the Oscillations of Insulin Secretion In Vitro and In Vivo | Diabetes | 2002 | 147 |
| 49 | The Mitochondrial Ca2+ Uniporter MCU Is Essential for Glucose-Induced ATP Increases in Pancreatic β-Cells | PLoS ONE | 2012 | 146 |
| 50 | Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury | Hepatology | 2009 | 143 |
