| # | Title | Journal | Year | Citations |
|---|
| 1 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 2 | Standardization of sample collection, isolation and analysis methods in extracellular vesicle research | Journal of Extracellular Vesicles | 2013 | 1,837 |
| 3 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 4 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 5 | Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation | PLoS Biology | 2012 | 1,064 |
| 6 | Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study | Gastroenterology | 2021 | 913 |
| 7 | European consensus conference on faecal microbiota transplantation in clinical practice | Gut | 2017 | 793 |
| 8 | Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes | Journal of Extracellular Vesicles | 2013 | 774 |
| 9 | Irritable bowel syndrome | Nature Reviews Disease Primers | 2016 | 674 |
| 10 | An atlas of genetic influences on osteoporosis in humans and mice | Nature Genetics | 2019 | 557 |
| 11 | A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX | Journal of Bone and Mineral Research | 2016 | 508 |
| 12 | Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture | Nature | 2015 | 483 |
| 13 | Identification of an Intestinal Microbiota Signature Associated With Severity of Irritable Bowel Syndrome | Gastroenterology | 2017 | 470 |
| 14 | Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome as Well as Traditional Dietary Advice: A Randomized Controlled Trial | Gastroenterology | 2015 | 463 |
| 15 | The power of genetic diversity in genome-wide association studies of lipids | Nature | 2021 | 353 |
| 16 | The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study | PLoS Genetics | 2015 | 331 |
| 17 | Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders | American Journal of Human Genetics | 2018 | 326 |
| 18 | Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels | Nature Communications | 2018 | 295 |
| 19 | Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects | American Journal of Human Genetics | 2018 | 252 |
| 20 | Prevalence of Rome IV Functional Bowel Disorders Among Adults in the United States, Canada, and the United Kingdom | Gastroenterology | 2020 | 249 |
| 21 | Measurement of a Comprehensive Sex Steroid Profile in Rodent Serum by High-Sensitive Gas Chromatography-Tandem Mass Spectrometry | Endocrinology | 2015 | 246 |
| 22 | New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk | Nature Communications | 2016 | 245 |
| 23 | Sex Steroid Actions in Male Bone | Endocrine Reviews | 2014 | 239 |
| 24 | Deviations in human gut microbiota: a novel diagnostic test for determining dysbiosis in patients with IBS or IBD | Alimentary Pharmacology and Therapeutics | 2015 | 218 |
| 25 | Associations of pre-pregnancy body mass index and gestational weight gain with pregnancy outcome and postpartum weight retention: a prospective observational cohort study | BMC Pregnancy and Childbirth | 2014 | 209 |
| 26 | Metabolic effects of Lactobacillus reuteriDSM 17938 in people with type 2 diabetes: A randomized controlled trial | Diabetes, Obesity and Metabolism | 2017 | 199 |
| 27 | Epidemiology, clinical characteristics, and associations for symptom-based Rome IV functional dyspepsia in adults in the USA, Canada, and the UK: a cross-sectional population-based study | The Lancet Gastroenterology and Hepatology | 2018 | 199 |
| 28 | Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome | Nature Medicine | 2019 | 193 |
| 29 | MicroRNA-155 is essential for TH2-mediated allergen-induced eosinophilic inflammation in the lung | Journal of Allergy and Clinical Immunology | 2014 | 192 |
| 30 | RNAi delivery by exosome-mimetic nanovesicles – Implications for targeting c-Myc in cancer | Biomaterials | 2016 | 188 |
| 31 | Visceral hypersensitivity is associated with GI symptom severity in functional GI disorders: consistent findings from five different patient cohorts | Gut | 2018 | 186 |
| 32 | Multivariate modelling of faecal bacterial profiles of patients with IBS predicts responsiveness to a diet low in FODMAPs | Gut | 2018 | 176 |
| 33 | Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo‐controlled, double‐blind, clinical trial | Journal of Internal Medicine | 2018 | 169 |
| 34 | Increased colonic bile acid exposure: a relevant factor for symptoms and treatment in IBS | Gut | 2015 | 167 |
| 35 | Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults | PLoS Genetics | 2017 | 158 |
| 36 | A Small Particle Size Diet Reduces Upper Gastrointestinal Symptoms in Patients With Diabetic Gastroparesis: A Randomized Controlled Trial | American Journal of Gastroenterology | 2014 | 155 |
| 37 | Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels | Nature Communications | 2016 | 153 |
| 38 | An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation | Expert Review of Gastroenterology and Hepatology | 2020 | 148 |
| 39 | Crosstalk at the mucosal border: importance of the gut microenvironment in IBS | Nature Reviews Gastroenterology and Hepatology | 2015 | 147 |
| 40 | Methods for the physical characterization and quantification of extracellular vesicles in biological samples | Biochimica Et Biophysica Acta - General Subjects | 2017 | 138 |
| 41 | The Prevalence and Impact of Overlapping Rome IV-Diagnosed Functional Gastrointestinal Disorders on Somatization, Quality of Life, and Healthcare Utilization: A Cross-Sectional General Population Study in Three Countries | American Journal of Gastroenterology | 2018 | 138 |
| 42 | Determination of Exosome Concentration in Solution Using Surface Plasmon Resonance Spectroscopy | Analytical Chemistry | 2014 | 133 |
| 43 | A rapid, automated surface protein profiling of single circulating exosomes in human blood | Scientific Reports | 2016 | 133 |
| 44 | Cytokine imbalance in irritable bowel syndrome: a systematic review and meta‐analysis | Neurogastroenterology and Motility | 2014 | 130 |
| 45 | Work Productivity and Activity Impairment in Irritable Bowel Syndrome (IBS): A Multifaceted Problem | American Journal of Gastroenterology | 2018 | 127 |
| 46 | Functional variants in the sucrase–isomaltase gene associate with increased risk of irritable bowel syndrome | Gut | 2018 | 120 |
| 47 | Putative Cut‐Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis | Journal of the American Geriatrics Society | 2020 | 120 |
| 48 | Estrogen receptor-α in osteocytes is important for trabecular bone formation in male mice | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 118 |
| 49 | The gut microbiota is a major regulator of androgen metabolism in intestinal contents | American Journal of Physiology - Endocrinology and Metabolism | 2019 | 118 |
| 50 | Macrophage and dendritic cell subsets in IBD: ALDH+ cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammation | Mucosal Immunology | 2016 | 115 |
