| # | Title | Journal | Year | Citations |
|---|
| 1 | Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress | Toxicology and Applied Pharmacology | 2006 | 804 |
| 2 | Towards an assessment of multiple ecosystem processes and services via functional traits | Biodiversity and Conservation | 2010 | 759 |
| 3 | Ubiquitin tag for sperm mitochondria | Nature | 1999 | 558 |
| 4 | Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells | Human Reproduction Update | 2009 | 381 |
| 5 | Ubiquitinated Sperm Mitochondria, Selective Proteolysis, and the Regulation of Mitochondrial Inheritance in Mammalian Embryos1 | Biology of Reproduction | 2000 | 365 |
| 6 | Diabetes and the Impairment of Reproductive Function: Possible Role of Mitochondria and Reactive Oxygen Species | Current Diabetes Reviews | 2008 | 276 |
| 7 | The key role of mitochondria in Alzheimer's disease | Journal of Alzheimer's Disease | 2006 | 273 |
| 8 | Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems | Pharmaceuticals | 2010 | 255 |
| 9 | Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024 | Neurochemical Research | 2002 | 250 |
| 10 | Role of the brain‐derived neurotrophic factor at glutamatergic synapses | British Journal of Pharmacology | 2008 | 248 |
| 11 | The Expression of Mitochondrial DNA Transcription Factors during Early Cardiomyocyte In Vitro Differentiation from Human Embryonic Stem Cells | Cloning and Stem Cells | 2005 | 216 |
| 12 | Brain-derived Neurotrophic Factor Regulates the Expression and Synaptic Delivery ofα-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor Subunits in Hippocampal Neurons | Journal of Biological Chemistry | 2007 | 212 |
| 13 | BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons | Molecular and Cellular Neurosciences | 2007 | 210 |
| 14 | Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity | Toxicology and Applied Pharmacology | 2004 | 202 |
| 15 | Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades | Neuroscience | 2008 | 201 |
| 16 | Dynamic changes in seagrass assemblages under eutrophication and implications for recovery | Journal of Experimental Marine Biology and Ecology | 2004 | 193 |
| 17 | Doxorubicin-induced persistent oxidative stress to cardiac myocytes | Toxicology Letters | 2001 | 190 |
| 18 | Intracellular signaling mechanisms in photodynamic therapy | Biochimica Et Biophysica Acta: Reviews on Cancer | 2004 | 184 |
| 19 | Mitochondrially-mediated toxicity of bile acids | Toxicology | 2004 | 180 |
| 20 | An Integrative View of the Role of Oxidative Stress, Mitochondria and Insulin in Alzheimer's Disease | Journal of Alzheimer's Disease | 2009 | 172 |
| 21 | Hydrodynamics as a Major Factor Controlling the Occurrence of Green Macroalgal Blooms in a Eutrophic Estuary: A Case Study on the Influence of Precipitation and River Management | Estuarine, Coastal and Shelf Science | 2001 | 162 |
| 22 | Calculations of exergy for organisms | Ecological Modelling | 2005 | 156 |
| 23 | Parabens in male infertility—Is there a mitochondrial connection? | Reproductive Toxicology | 2009 | 155 |
| 24 | Diversity and activity of aquatic fungi under low oxygen conditions | Freshwater Biology | 2009 | 155 |
| 25 | Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes | Journal of the Neurological Sciences | 2007 | 154 |
| 26 | Leaf Barriers to Fungal Colonization and Shredders ( Tipula lateralis ) Consumption of Decomposing Eucalyptus globulus | Microbial Ecology | 1999 | 152 |
| 27 | Phosphorus speciation and availability in intertidal sediments of a temperate estuary: relation to eutrophication and annual P-fluxes | Estuarine, Coastal and Shelf Science | 2004 | 151 |
| 28 | Impact of eutrophication and river management within a framework of ecosystem theories | Ecological Modelling | 2003 | 150 |
| 29 | Climate Change Impacts on Seagrass Meadows and Macroalgal Forests: An Integrative Perspective on Acclimation and Adaptation Potential | Frontiers in Marine Science | 2018 | 149 |
| 30 | Effects of hyperglycemia on sperm and testicular cells of Goto-Kakizaki and streptozotocin-treated rat models for diabetes | Theriogenology | 2006 | 145 |
| 31 | Bile Acids Affect Liver Mitochondrial Bioenergetics: Possible Relevance for Cholestasis Therapy | Toxicological Sciences | 2000 | 143 |
| 32 | A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice | Journal of Lipid Research | 2014 | 141 |
| 33 | User-friendly guide for using benthic ecological indicators in coastal and marine quality assessment | Ocean and Coastal Management | 2006 | 140 |
| 34 | Cardioselective and cumulative oxidation of mitochondrial DNA following subchronic doxorubicin administration | Biochimica Et Biophysica Acta - Bioenergetics | 1999 | 134 |
| 35 | Nutrient cycling and plant dynamics in estuaries: A brief review | Acta Oecologica | 1999 | 133 |
| 36 | Mitochondrially Targeted Effects of Berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 Mouse Melanoma Cells: Comparison with Direct Effects on Isolated Mitochondrial Fractions | Journal of Pharmacology and Experimental Therapeutics | 2007 | 132 |
| 37 | Effect of amyloid ?-peptide on permeability transition pore: A comparative study | Journal of Neuroscience Research | 2002 | 128 |
| 38 | Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3β signaling pathways and changes in protein expression | Biochimica Et Biophysica Acta - Molecular Cell Research | 2008 | 122 |
| 39 | Regulation of AMPA receptors and synaptic plasticity | Neuroscience | 2009 | 121 |
| 40 | Interactions of Herbicides 2,4-D and Dinoseb with Liver Mitochondrial Bioenergetics | Toxicology and Applied Pharmacology | 1994 | 120 |
| 41 | Amyloid β-Peptide Promotes Permeability Transition Pore in Brain Mitochondria | Bioscience Reports | 2001 | 120 |
| 42 | Mercury pollution in Ria de Aveiro (Portugal): a review of the system assessment | Environmental Monitoring and Assessment | 2009 | 120 |
| 43 | Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line | Cancer Chemotherapy and Pharmacology | 2008 | 117 |
| 44 | Heavy metal accumulation in Halimione portulacoides: Intra- and extra-cellular metal binding sites | Chemosphere | 2008 | 117 |
| 45 | The expression of polymerase gamma and mitochondrial transcription factor A and the regulation of mitochondrial DNA content in mature human sperm | Human Reproduction | 2007 | 116 |
| 46 | Hyperglycemia decreases mitochondrial function: The regulatory role of mitochondrial biogenesis | Toxicology and Applied Pharmacology | 2007 | 114 |
| 47 | Macroalgae response to a mercury contamination gradient in a temperate coastal lagoon (Ria de Aveiro, Portugal) | Estuarine, Coastal and Shelf Science | 2005 | 112 |
| 48 | Management of a shallow temperate estuary to control eutrophication: The effect of hydrodynamics on the system’s nutrient loading | Estuarine, Coastal and Shelf Science | 2005 | 112 |
| 49 | The impact of extreme flooding events and anthropogenic stressors on the macrobenthic communities’ dynamics | Estuarine, Coastal and Shelf Science | 2008 | 112 |
| 50 | Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor | Arthritis Research and Therapy | 2009 | 112 |
