| # | Title | Journal | Year | Citations |
|---|
| 1 | The burden of non-communicable diseases in South Africa | Lancet, The | 2009 | 748 |
| 2 | Controversies in ventricular remodelling | Lancet, The | 2006 | 742 |
| 3 | Global birth prevalence of congenital heart defects 1970–2017: updated systematic review and meta-analysis of 260 studies | International Journal of Epidemiology | 2019 | 643 |
| 4 | Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance | JAMA - Journal of the American Medical Association | 2018 | 538 |
| 5 | The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis | Lancet Respiratory Medicine,the | 2017 | 459 |
| 6 | Risk Factors for Coronavirus Disease 2019 (COVID-19) Death in a Population Cohort Study from the Western Cape Province, South Africa | Clinical Infectious Diseases | 2021 | 405 |
| 7 | Health in South Africa: changes and challenges since 2009 | Lancet, The | 2012 | 396 |
| 8 | Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: the Global Rheumatic Heart Disease Registry (the REMEDY study) | European Heart Journal | 2015 | 391 |
| 9 | Tuberculous Pericarditis | Circulation | 2005 | 389 |
| 10 | 14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial | Lancet, The | 2012 | 387 |
| 11 | Acute rheumatic fever and rheumatic heart disease | Nature Reviews Disease Primers | 2016 | 371 |
| 12 | Health and Health Care in South Africa — 20 Years after Mandela | New England Journal of Medicine | 2014 | 338 |
| 13 | Antibiotic stewardship in low- and middle-income countries: the same but different? | Clinical Microbiology and Infection | 2017 | 323 |
| 14 | Metabolism of free fatty acids, glucose and catecholamines in acute myocardial infarction | American Journal of Cardiology | 1975 | 314 |
| 15 | Detection of Tuberculosis in HIV-Infected and -Uninfected African Adults Using Whole Blood RNA Expression Signatures: A Case-Control Study | PLoS Medicine | 2013 | 314 |
| 16 | A standardised method for interpreting the association between mutations and phenotypic drug resistance inMycobacterium tuberculosis | European Respiratory Journal | 2017 | 273 |
| 17 | Miliary tuberculosis: Rapid diagnosis, hematologic abnormalities, and outcome in 109 treated adults | American Journal of Medicine | 1990 | 258 |
| 18 | Contributions of risk factors and medical care to cardiovascular mortality trends | Nature Reviews Cardiology | 2015 | 243 |
| 19 | Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial | Lancet, The | 2018 | 236 |
| 20 | Hepatitis B virus x protein in the pathogenesis of hepatitis B virus‐induced hepatocellular carcinoma | Journal of Gastroenterology and Hepatology (Australia) | 2011 | 233 |
| 21 | Position statement of the World Heart Federation on the prevention and control of rheumatic heart disease | Nature Reviews Cardiology | 2013 | 224 |
| 22 | Clinical Outcomes in 3343 Children and Adults With Rheumatic Heart Disease From 14 Low- and Middle-Income Countries | Circulation | 2016 | 213 |
| 23 | Diabetes in Africa: epidemiology, management and healthcare challenges | Heart | 2008 | 209 |
| 24 | Biochemical aspects of arrhythmogenesis and ventricular fibrillation | American Journal of Cardiology | 1979 | 193 |
| 25 | Contemporary trends in the epidemiology and management of cardiomyopathy and pericarditis in sub-Saharan Africa | Heart | 2007 | 191 |
| 26 | Modified early warning score predicts the need for hospital admission and inhospital mortality | Emergency Medicine Journal | 2008 | 186 |
| 27 | Systems medicine and integrated care to combat chronic noncommunicable diseases | Genome Medicine | 2011 | 181 |
| 28 | Global prevalence of resistant hypertension: a meta-analysis of data from 3.2 million patients | Heart | 2019 | 180 |
| 29 | Metformin in management of pregnant insulin-independent diabetics | Diabetologia | 1979 | 167 |
| 30 | Characterization of the “border zone” in acute regional ischemia in the dog | American Journal of Cardiology | 1977 | 161 |
| 31 | Modulation of severity of reperfusion stunning in the isolated rat heart by agents altering calcium flux at onset of reperfusion. | Circulation Research | 1992 | 161 |
| 32 | The Lancet Infectious Diseases Commission on antimicrobial resistance: 6 years later | Lancet Infectious Diseases, The | 2020 | 161 |
| 33 | Hepatic Iron Overload and Hepatocellular Carcinoma | Liver Cancer | 2014 | 160 |
| 34 | Antibiotics for the primary prevention of acute rheumatic fever: a meta-analysis | BMC Cardiovascular Disorders | 2005 | 155 |
| 35 | Triage strategy for urgent management of cardiac tamponade: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases | European Heart Journal | 2014 | 154 |
| 36 | Incidence of acute rheumatic fever in the world: a systematic review of population-based studies | Heart | 2008 | 153 |
| 37 | Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment | Lancet Respiratory Medicine,the | 2013 | 151 |
| 38 | Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives | Bioorganic and Medicinal Chemistry | 2005 | 150 |
| 39 | Stroke in patients with human immunodeficiency virus infection | Journal of Neurology, Neurosurgery and Psychiatry | 2007 | 146 |
| 40 | Long-COVID: An evolving problem with an extensive impact | South African Medical Journal | 2020 | 146 |
| 41 | Chronic obstructive airways disease following treated pulmonary tuberculosis | Respiratory Medicine | 1989 | 137 |
| 42 | Tobacco smoking and COVID-19 infection | Lancet Respiratory Medicine,the | 2020 | 134 |
| 43 | Congenital heart disease and rheumatic heart disease in Africa: recent advances and current priorities | Heart | 2013 | 133 |
| 44 | Aetiology and risk factors of peripartum cardiomyopathy: A systematic review | International Journal of Cardiology | 2009 | 130 |
| 45 | A Modern Approach to Tuberculous Pericarditis | Progress in Cardiovascular Diseases | 2007 | 128 |
| 46 | Loss of trabecular bone mineral density in systemic lupus erythematosus | Arthritis and Rheumatism | 1993 | 127 |
| 47 | Novel web-based tools combining chemistry informatics, biology and social networks for drug discovery | Drug Discovery Today | 2009 | 126 |
| 48 | III. CALCIUM ANTAGONISTS | Lancet, The | 1980 | 123 |
| 49 | Maximising access to achieve appropriate human antimicrobial use in low-income and middle-income countries | Lancet, The | 2016 | 123 |
| 50 | Antiphospholipid Antibodies Associated with Malignancies: Clinical and Pathological Characteristics of 120 Patients | Seminars in Arthritis and Rheumatism | 2006 | 122 |
