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Top Articles

#TitleJournalYearCitations
1Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertensionNature19972,733
2Prostanoid Receptors: Structures, Properties, and FunctionsPhysiological Reviews19992,228
3CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1Nature Genetics19941,717
4Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinaseScience19991,403
5Canonical Wnt Signaling in Differentiated Osteoblasts Controls Osteoclast DifferentiationDevelopmental Cell20051,402
6Focal Contacts as MechanosensorsJournal of Cell Biology20011,331
7An endothelial receptor for oxidized low-density lipoproteinNature19971,259
8Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into ChondrocytesDevelopmental Cell20051,022
9Prostaglandin E ReceptorsJournal of Biological Chemistry2007990
10Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like PropertiesCell2013889
11Cooperation between mDia1 and ROCK in Rho-induced actin reorganizationNature Cell Biology1999793
12The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.EMBO Journal1996789
13p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilinEMBO Journal1997748
14Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinasesMolecular Pharmacology2000746
15Altered pain perception and inflammatory response in mice lacking prostacyclin receptorNature1997732
16Cloning and expression of cDNA for a human thromboxane A2 receptorNature1991700
17Prostaglandin D 2 as a Mediator of Allergic AsthmaScience2000699
18Wnt/β-catenin signaling controls development of the blood–brain barrierJournal of Cell Biology2008680
19ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in miceFEBS Letters1996673
20Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow NicheCell2011654
21Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3Nature1998630
22Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cellsNature Biotechnology2008590
23An essential part for Rho–associated kinase in the transcellular invasion of tumor cellsNature Medicine1999576
24Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout miceNature Medicine2001562
25Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificityNature1993548
26Expanded polyglutamine in the Machado–Joseph disease protein induces cell death in vitro and in vivoNature Genetics1996535
27HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interactionNature Neuroscience2009517
28Asparagine residue in the rho Gene Product Is the Modification Site for Botulinum ADP-ribosyltransferaseJournal of Biological Chemistry1989511
29Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansionNature Medicine2009498
30Rho signaling, ROCK and mDia1, in transformation, metastasis and invasionCancer and Metastasis Reviews2009477
31Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cellsBritish Journal of Pharmacology1997474
32Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex IDiabetes2008470
33p160ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesionsFEBS Letters1997468
34Sensitization of TRPV1 by EP1 and IP Reveals Peripheral Nociceptive Mechanism of ProstaglandinsMolecular Pain2005460
35Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 CellsJournal of Cell Biology1998448
36β-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous systemDevelopmental Biology2003442
37Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferaseJournal of Biological Chemistry1989438
38Adenomatous polyposis coli (APC): a multi-functional tumor suppressor geneJournal of Cell Science2007423
39Molecular and cellular mechanism of endothelin regulation. Implications for vascular function.Circulation1991413
40Activation of  -catenin signaling by Rspo1 controls differentiation of the mammalian ovaryHuman Molecular Genetics2008407
41Instructive Role of Wnt/ß-Catenin in Sensory Fate Specification in Neural Crest Stem CellsScience2004393
42Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase RhoScience1996388
43Role of citron kinase as a target of the small GTPase Rho in cytokinesisNature1998378
44Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem CellsCell Stem Cell2010370
45The Small GTPase Rho: Cellular Functions and Signal TransductionJournal of Biochemistry1996366
46Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cellsProceedings of the National Academy of Sciences of the United States of America1998361
47Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signalingProceedings of the National Academy of Sciences of the United States of America2006355
48Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulbNature1993354
49The Role of Prostaglandin E Receptor Subtypes (EP1, EP2, EP3, and EP4) in Bone Resorption: An Analysis Using Specific Agonists for the Respective EPsEndocrinology2000354
50β-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouseDevelopmental Biology2006348