# | Title | Journal | Year | Citations |
---|
1 | Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension | Nature | 1997 | 2,733 |
2 | Prostanoid Receptors: Structures, Properties, and Functions | Physiological Reviews | 1999 | 2,228 |
3 | CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1 | Nature Genetics | 1994 | 1,717 |
4 | Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase | Science | 1999 | 1,403 |
5 | Canonical Wnt Signaling in Differentiated Osteoblasts Controls Osteoclast Differentiation | Developmental Cell | 2005 | 1,402 |
6 | Focal Contacts as Mechanosensors | Journal of Cell Biology | 2001 | 1,331 |
7 | An endothelial receptor for oxidized low-density lipoprotein | Nature | 1997 | 1,259 |
8 | Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes | Developmental Cell | 2005 | 1,022 |
9 | Prostaglandin E Receptors | Journal of Biological Chemistry | 2007 | 990 |
10 | Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties | Cell | 2013 | 889 |
11 | Cooperation between mDia1 and ROCK in Rho-induced actin reorganization | Nature Cell Biology | 1999 | 793 |
12 | The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. | EMBO Journal | 1996 | 789 |
13 | p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin | EMBO Journal | 1997 | 748 |
14 | Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases | Molecular Pharmacology | 2000 | 746 |
15 | Altered pain perception and inflammatory response in mice lacking prostacyclin receptor | Nature | 1997 | 732 |
16 | Cloning and expression of cDNA for a human thromboxane A2 receptor | Nature | 1991 | 700 |
17 | Prostaglandin D 2 as a Mediator of Allergic Asthma | Science | 2000 | 699 |
18 | Wnt/β-catenin signaling controls development of the blood–brain barrier | Journal of Cell Biology | 2008 | 680 |
19 | ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice | FEBS Letters | 1996 | 673 |
20 | Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche | Cell | 2011 | 654 |
21 | Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3 | Nature | 1998 | 630 |
22 | Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells | Nature Biotechnology | 2008 | 590 |
23 | An essential part for Rho–associated kinase in the transcellular invasion of tumor cells | Nature Medicine | 1999 | 576 |
24 | Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice | Nature Medicine | 2001 | 562 |
25 | Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity | Nature | 1993 | 548 |
26 | Expanded polyglutamine in the Machado–Joseph disease protein induces cell death in vitro and in vivo | Nature Genetics | 1996 | 535 |
27 | HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction | Nature Neuroscience | 2009 | 517 |
28 | Asparagine residue in the rho Gene Product Is the Modification Site for Botulinum ADP-ribosyltransferase | Journal of Biological Chemistry | 1989 | 511 |
29 | Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion | Nature Medicine | 2009 | 498 |
30 | Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion | Cancer and Metastasis Reviews | 2009 | 477 |
31 | Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells | British Journal of Pharmacology | 1997 | 474 |
32 | Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I | Diabetes | 2008 | 470 |
33 | p160ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions | FEBS Letters | 1997 | 468 |
34 | Sensitization of TRPV1 by EP1 and IP Reveals Peripheral Nociceptive Mechanism of Prostaglandins | Molecular Pain | 2005 | 460 |
35 | Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells | Journal of Cell Biology | 1998 | 448 |
36 | β-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system | Developmental Biology | 2003 | 442 |
37 | Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase | Journal of Biological Chemistry | 1989 | 438 |
38 | Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene | Journal of Cell Science | 2007 | 423 |
39 | Molecular and cellular mechanism of endothelin regulation. Implications for vascular function. | Circulation | 1991 | 413 |
40 | Activation of -catenin signaling by Rspo1 controls differentiation of the mammalian ovary | Human Molecular Genetics | 2008 | 407 |
41 | Instructive Role of Wnt/ß-Catenin in Sensory Fate Specification in Neural Crest Stem Cells | Science | 2004 | 393 |
42 | Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho | Science | 1996 | 388 |
43 | Role of citron kinase as a target of the small GTPase Rho in cytokinesis | Nature | 1998 | 378 |
44 | Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem Cells | Cell Stem Cell | 2010 | 370 |
45 | The Small GTPase Rho: Cellular Functions and Signal Transduction | Journal of Biochemistry | 1996 | 366 |
46 | Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 361 |
47 | Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 355 |
48 | Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb | Nature | 1993 | 354 |
49 | The Role of Prostaglandin E Receptor Subtypes (EP1, EP2, EP3, and EP4) in Bone Resorption: An Analysis Using Specific Agonists for the Respective EPs | Endocrinology | 2000 | 354 |
50 | β-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse | Developmental Biology | 2006 | 348 |