# | Title | Journal | Year | Citations |
---|
1 | Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease | Nature Genetics | 2009 | 2,697 |
2 | Clinical diagnostic criteria for dementia associated with Parkinson's disease | Movement Disorders | 2007 | 2,497 |
3 | Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17 | Nature | 2006 | 1,816 |
4 | Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease | Nature Genetics | 2011 | 1,708 |
5 | Diagnostic procedures for Parkinson's disease dementia: Recommendations from the movement disorder society task force | Movement Disorders | 2007 | 885 |
6 | TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia | Lancet Neurology, The | 2010 | 816 |
7 | TDP‐43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease | Annals of Neurology | 2007 | 753 |
8 | The secretases: enzymes with therapeutic potential in Alzheimer disease | Nature Reviews Neurology | 2010 | 702 |
9 | Acetylcholinesterase: From 3D structure to function | Chemico-Biological Interactions | 2010 | 557 |
10 | The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins | Journal of Clinical Investigation | 2007 | 545 |
11 | Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration | Human Molecular Genetics | 2006 | 529 |
12 | Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 523 |
13 | Structural determinants of the cellular localization and shuttling of TDP-43 | Journal of Cell Science | 2008 | 493 |
14 | High-Resolution Whole-Genome Association Study of Parkinson Disease | American Journal of Human Genetics | 2005 | 479 |
15 | LRRK2 in Parkinson's disease: protein domains and functional insights | Trends in Neurosciences | 2006 | 439 |
16 | The role of tau in neurodegeneration | Molecular Neurodegeneration | 2009 | 353 |
17 | Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease | PLoS ONE | 2010 | 347 |
18 | Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease | Nature Medicine | 2010 | 342 |
19 | Progranulin Mediates Caspase-Dependent Cleavage of TAR DNA Binding Protein-43 | Journal of Neuroscience | 2007 | 339 |
20 | Aβ40 Inhibits Amyloid DepositionIn Vivo | Journal of Neuroscience | 2007 | 327 |
21 | Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias | PLoS Genetics | 2014 | 305 |
22 | IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior | Neuron | 2015 | 292 |
23 | Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease | Nature Genetics | 2009 | 279 |
24 | Substrate-targeting γ-secretase modulators | Nature | 2008 | 277 |
25 | Diverse compounds mimic Alzheimer disease–causing mutations by augmenting Aβ42 production | Nature Medicine | 2005 | 276 |
26 | A decade of modeling Alzheimer's disease in transgenic mice | Trends in Genetics | 2006 | 266 |
27 | Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging | American Journal of Pathology | 2010 | 262 |
28 | Lrrk2 and Lewy body disease | Annals of Neurology | 2006 | 259 |
29 | Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21 | Nature Immunology | 2005 | 252 |
30 | Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species | Biochemistry | 2008 | 247 |
31 | Differential Expression of Cholesterol Hydroxylases in Alzheimer's Disease | Journal of Biological Chemistry | 2004 | 238 |
32 | Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease | Acta Neuropathologica | 2009 | 237 |
33 | Large-scale topology and the default mode network in the mouse connectome | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 228 |
34 | Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology | Nature Genetics | 2021 | 223 |
35 | Actin-binding Proteins Coronin-1a and IBA-1 are Effective Microglial Markers for Immunohistochemistry | Journal of Histochemistry and Cytochemistry | 2007 | 214 |
36 | TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers | Neurology | 2011 | 211 |
37 | Genome-wide association study of Alzheimer's disease | Translational Psychiatry | 2012 | 209 |
38 | Notch signaling is activated by TLR stimulation and regulates macrophage functions | European Journal of Immunology | 2008 | 207 |
39 | Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease | Annals of Neurology | 2008 | 207 |
40 | Neurotoxic effects of TDP-43 overexpression in C. elegans | Human Molecular Genetics | 2010 | 205 |
41 | Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C→T (Arg493X) mutation: an international initiative | Lancet Neurology, The | 2007 | 199 |
42 | APOE ε4 lowers age at onset and is a high risk factor for Alzheimer's disease; A case control study from central Norway | BMC Neurology | 2008 | 196 |
43 | CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 195 |
44 | Progranulin in frontotemporal lobar degeneration and neuroinflammation | Journal of Neuroinflammation | 2007 | 194 |
45 | Clinical features of LRRK2‐associated Parkinson's disease in central Norway | Annals of Neurology | 2005 | 184 |
46 | Efficient Neuronal Gene Transfer with AAV8 Leads to Neurotoxic Levels of Tau or Green Fluorescent Proteins | Molecular Therapy | 2006 | 180 |
47 | Aβ-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention | Biochemical Society Transactions | 2005 | 179 |
48 | Regulation of Steady-state β-Amyloid Levels in the Brain by Neprilysin and Endothelin-converting Enzyme but Not Angiotensin-converting Enzyme | Journal of Biological Chemistry | 2006 | 177 |
49 | Anti-A 42- and anti-A 40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model | Journal of Clinical Investigation | 2005 | 172 |
50 | Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy | Nature Communications | 2015 | 170 |