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Top Articles

#TitleJournalYearCitations
1Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agentsBioorganic and Medicinal Chemistry2009288
2Hydrogen sulfide acts as a regulator of flower senescence in plantsPostharvest Biology and Technology2011214
3Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injuryAmerican Journal of Physiology - Renal Physiology2012194
4Evaluation and Discovery of Novel Synthetic Chalcone Derivatives as Anti-Inflammatory AgentsJournal of Medicinal Chemistry2011182
5Flavonoid Apigenin Inhibits Lipopolysaccharide-Induced Inflammatory Response through Multiple Mechanisms in MacrophagesPLoS ONE2014182
6Role of pyroptosis in cardiovascular diseasesInternational Immunopharmacology2019171
7Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activationCell Death and Disease2019168
8Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in uteroProceedings of the National Academy of Sciences of the United States of America2008157
9Serum Levels of FGF-21 Are Increased in Coronary Heart Disease Patients and Are Independently Associated with Adverse Lipid ProfilePLoS ONE2010157
10The Anti-Scar Effects of Basic Fibroblast Growth Factor on the Wound Repair In Vitro and In VivoPLoS ONE2013154
11Phthalate-induced testicular dysgenesis syndrome: Leydig cell influenceTrends in Endocrinology and Metabolism2009144
12Enhanced wound‐healing quality with bone marrow mesenchymal stem cells autografting after skin injuryWound Repair and Regeneration2006141
13Regulation of Autophagy and Ubiquitinated Protein Accumulation by bFGF Promotes Functional Recovery and Neural Protection in a Rat Model of Spinal Cord InjuryMolecular Neurobiology2013141
14Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLBPLoS ONE2012139
15Synthesis, crystal structure and anti-inflammatory properties of curcumin analoguesEuropean Journal of Medicinal Chemistry2009117
16Synthesis and Anti-bacterial Properties of Mono-carbonyl Analogues of CurcuminChemical and Pharmaceutical Bulletin2008111
17Exogenous Basic Fibroblast Growth Factor Inhibits ER Stress–Induced Apoptosis and Improves Recovery from Spinal Cord InjuryCNS Neuroscience and Therapeutics2013111
18FGF Family: From Drug Development to Clinical ApplicationInternational Journal of Molecular Sciences2018110
19Electrochemical sensor for toxic ractopamine and clenbuterol based on the enhancement effect of graphene oxideSensors and Actuators B: Chemical2012109
20Copper-Catalyzed Three-Component Reaction for Regioselective Aryl- and Heteroarylselenation of Indoles using Selenium PowderJournal of Organic Chemistry2016109
21Activation of the AMP activated protein kinase by short-chain fatty acids is the main mechanism underlying the beneficial effect of a high fiber diet on the metabolic syndromeMedical Hypotheses2010107
22Apelin inhibits the proliferation and migration of rat PASMCs via the activation of PI3K/Akt/mTOR signal and the inhibition of autophagy under hypoxiaJournal of Cellular and Molecular Medicine2014106
23Circulating FGF21 Levels Are Progressively Increased from the Early to End Stages of Chronic Kidney Diseases and Are Associated with Renal Function in ChinesePLoS ONE201199
24bFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia/reperfusion via the activation of the PI3K/Akt/mTOR pathwayScientific Reports201599
25bFGF inhibits ER stress induced by ischemic oxidative injury via activation of the PI3K/Akt and ERK1/2 pathwaysToxicology Letters201298
26bFGF Protects Against Blood-Brain Barrier Damage Through Junction Protein Regulation via PI3K-Akt-Rac1 Pathway Following Traumatic Brain InjuryMolecular Neurobiology201697
27Nerve growth factor improves functional recovery by inhibiting endoplasmic reticulum stress-induced neuronal apoptosis in rats with spinal cord injuryJournal of Translational Medicine201496
28Fibroblast Growth Factors Stimulate Hair Growth throughβ-Catenin and Shh Expression in C57BL/6 MiceBioMed Research International201594
29Synthesis and Anti-inflammatory Evaluation of Novel Benzimidazole and Imidazopyridine DerivativesACS Medicinal Chemistry Letters201391
30The effect of resveratrol on beta amyloid-induced memory impairment involves inhibition of phosphodiesterase-4 related signalingOncotarget201689
31Inhibition of phosphodiesterase 2 reverses impaired cognition and neuronal remodeling caused by chronic stressNeurobiology of Aging201588
32bFGF attenuates endoplasmic reticulum stress and mitochondrial injury on myocardial ischaemia/reperfusion via activation of PI3K/Akt/ERK1/2 pathwayJournal of Cellular and Molecular Medicine201587
33Overexpression of BUB1B contributes to progression of prostate cancer and predicts poor outcome in patients with prostate cancerOncoTargets and Therapy201687
34Inhibition of human and rat testicular steroidogenic enzyme activities by bisphenol AToxicology Letters201185
35Deletion of the Igf1 Gene: Suppressive Effects on Adult Leydig Cell DevelopmentJournal of Andrology201077
36Rapid mechanisms of glucocorticoid signaling in the Leydig cell☆Steroids200875
37Adipose tissue extract enhances skin wound healingWound Repair and Regeneration200774
38Attenuation of Hyperlipidemia- and Diabetes-Induced Early-Stage Apoptosis and Late-Stage Renal Dysfunction via Administration of Fibroblast Growth Factor-21 Is Associated with Suppression of Renal InflammationPLoS ONE201374
39Berberine Inhibits HIV Protease Inhibitor-Induced Inflammatory Response by Modulating ER Stress Signaling Pathways in Murine MacrophagesPLoS ONE201072
40Inhibition of LPS‐induced production of inflammatory factors in the macrophages by mono‐carbonyl analogues of curcuminJournal of Cellular and Molecular Medicine200968
41FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver TumorigenesisDevelopmental Cell201968
4211β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors as Promising Therapeutic Drugs for Diabetes: Status and DevelopmentCurrent Medicinal Chemistry201067
43Copper-Catalyzed Three-Component Coupling Reaction of Azoles, Se Powder, and Aryl IodidesJournal of Organic Chemistry201767
44Application of bioactive hydrogels combined with dental pulp stem cells for the repair of large gap peripheral nerve injuriesBioactive Materials202167
45High-level expression and purification of soluble recombinant FGF21 protein by SUMO fusion in Escherichia coliBMC Biotechnology201062
46Multiple Low-Dose Radiation Prevents Type 2 Diabetes-Induced Renal Damage through Attenuation of Dyslipidemia and Insulin Resistance and Subsequent Renal Inflammation and Oxidative StressPLoS ONE201462
47The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus–pituitary–adrenal axisNeuropharmacology201560
48HIV Protease Inhibitors Disrupt Lipid Metabolism by Activating Endoplasmic Reticulum Stress and Inhibiting Autophagy Activity in AdipocytesPLoS ONE201360
49Systemic Perturbations of Key Metabolites in Diabetic Rats During the Evolution of Diabetes Studied by Urine MetabonomicsPLoS ONE201358
50NGF Accelerates Cutaneous Wound Healing by Promoting the Migration of Dermal Fibroblasts via the PI3K/Akt-Rac1-JNK and ERK PathwaysBioMed Research International201458