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Top Articles

#TitleJournalYearCitations
1S-Adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trialJournal of Hepatology1999428
2S‐Adenosylmethionine: a control switch that regulates liver functionFASEB Journal2002383
3New therapies for hepatocellular carcinomaOncogene2006362
4Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factorGastroenterology1998349
5Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapyJournal of Experimental Medicine2011303
6Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1AFASEB Journal2002259
7MethylthioadenosineInternational Journal of Biochemistry and Cell Biology2004192
8Amphiregulin: An early trigger of liver regeneration in miceGastroenterology2005173
9Serotonin Skews Human Macrophage Polarization through HTR2B and HTR7Journal of Immunology2013168
10Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in miceGut2013163
11Topical Application of a Peptide Inhibitor of Transforming Growth Factor-β1 Ameliorates Bleomycin-Induced Skin FibrosisJournal of Investigative Dermatology2005149
12Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12Hepatology2001139
13Abnormal Hepatic Methionine and Glutathione Metabolism in Patients With Alcoholic HepatitisAlcoholism: Clinical and Experimental Research2004138
14Methionine Adenosyltransferase S-Nitrosylation Is Regulated by the Basic and Acidic Amino Acids Surrounding the Target ThiolJournal of Biological Chemistry1999137
15Hepatitis C Virus Structural Proteins Impair Dendritic Cell Maturation and Inhibit In Vivo Induction of Cellular Immune ResponsesJournal of Virology2003127
16Amphiregulin Contributes to the Transformed Phenotype of Human Hepatocellular Carcinoma CellsCancer Research2006125
17The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosisHepatology2008124
18Nitric oxide inactivates rat hepatic methionine adenosyltransferasein vivo byS-nitrosylationHepatology1998118
19Protein Arginine Methyltransferase 5 Regulates ERK1/2 Signal Transduction Amplitude and Cell Fate Through CRAFScience Signaling2011118
20Upregulation of Indoleamine 2,3-Dioxygenase in Hepatitis C Virus InfectionJournal of Virology2007116
21Novel Role for Amphiregulin in Protection from Liver InjuryJournal of Biological Chemistry2005115
22Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8International Journal of Cancer2005112
23Connective tissue growth factor autocriny in human hepatocellular carcinoma: Oncogenic role and regulation by epidermal growth factor receptor/yes-associated protein-mediated activationHepatology2011108
24Poly(Anhydride) Nanoparticles Act as Active Th1 Adjuvants through Toll-Like Receptor ExploitationVaccine Journal2010107
25Cardiotrophin-1 Is a Key Regulator of Glucose and Lipid MetabolismCell Metabolism2011103
26In vitro and in vivo comparative study of chimeric liver-specific promotersMolecular Therapy200397
27Enoxaparin reduces hepatic vascular resistance and portal pressure in cirrhotic ratsJournal of Hepatology201697
28Model forIn VivoAssessment of Humoral Protection against Malaria Sporozoite Challenge by Passive Transfer of Monoclonal Antibodies and Immune SerumInfection and Immunity201496
29Defective regulation of cholangiocyte Cl− /HCO− 3 and Na+ /H+ exchanger activities in primary biliary cirrhosisHepatology200295
30Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injuryGut200595
31Successful Colon Cancer Eradication after Chemoimmunotherapy Is Associated with Profound Phenotypic Change of Intratumoral Myeloid CellsJournal of Immunology201192
32A synthetic peptide from transforming growth factor- 1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive ratsCardiovascular Research200889
33S–Adenosylmethionine Regulates Cytoplasmic HuR Via AMP–Activated KinaseGastroenterology200687
34Prolonged and inducible transgene expression in the liver using gutless adenovirus: A potential therapy for liver cancerGastroenterology200486
35Treatment of Pancreatic Cancer With an Oncolytic Adenovirus Expressing Interleukin-12 in Syrian HamstersMolecular Therapy200984
36Targeted expression of human serum albumin to potato tubersTransgenic Research200282
37Hepatocellular carcinoma and sorafenib: too many resistance mechanisms?Gut201382
38Amphiregulin: A new growth factor in hepatocarcinogenesisCancer Letters200780
39Regression of colon cancer and induction of antitumor immunity by intratumoral injection of adenovirus expressing interleukin-12Cancer Gene Therapy199979
40Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virusJournal of Pineal Research201177
41Anion exchanger 2 is essential for spermiogenesis in miceProceedings of the National Academy of Sciences of the United States of America200372
42Identification of peptide inhibitors of transforming growth factor beta 1 using a phage-displayed peptide libraryCytokine200769
43Eicosapentaenoic acid stimulates AMP-activated protein kinase and increases visfatin secretion in cultured murine adipocytesClinical Science200969
44In vivo gene transfer of CD40 ligand into colon cancer cells induces local production of cytokines and chemokines, tumor eradication and protective antitumor immunityGene Therapy200067
45Epidermal Growth Factor Receptor (EGFR) Crosstalks in Liver CancerCancers201165
46In Vitro and In Vivo Down-Regulation of Regulatory T Cell Activity with a Peptide Inhibitor of TGF-β1Journal of Immunology200863
47Gene Therapy of Cancer with Interleukin-12Current Pharmaceutical Design200363
48Cardiotrophin-1 defends the liver against ischemia-reperfusion injury and mediates the protective effect of ischemic preconditioningJournal of Experimental Medicine200662
49Peptide inhibitors of transforming growth factor‐β enhance the efficacy of antitumor immunotherapyInternational Journal of Cancer200962
50New molecular targets for hepatocellular carcinoma: the ErbB1 signaling systemLiver International200759