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Top Articles

#TitleJournalYearCitations
1ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromoleculesNucleic Acids Research20162,395
2The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and ForceDevelopmental Cell2017291
3CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapyScience Advances2020270
4Dynamic Ligand Discrimination in the Notch Signaling PathwayCell2018246
5Endothelial Notch1 Activity Facilitates MetastasisCancer Cell2017237
6Long-range charge transport in single G-quadruplex DNA moleculesNature Nanotechnology2014218
7Photosynthetic electron partitioning between [FeFe]-hydrogenase and ferredoxin:NADP + -oxidoreductase (FNR) enzymes in vitroProceedings of the National Academy of Sciences of the United States of America2011173
8Guidelines and recommendations on yeast cell death nomenclatureMicrobial Cell2018158
9Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent PatterningDevelopmental Cell2017146
10Paclitaxel-clusters coated with hyaluronan as selective tumor-targeted nanovectorsBiomaterials2010136
11MicroRNA miR-125b controls melanoma progression by direct regulation of c-Jun protein expressionOncogene2013128
12Proteasomal AAA-ATPases: Structure and functionBiochimica Et Biophysica Acta - Molecular Cell Research2012124
13Structure and function of wild-type and subunit-depleted photosystem I in SynechocystisBiochimica Et Biophysica Acta - Bioenergetics2018113
14The NAP motif of activity-dependent neuroprotective protein (ADNP) regulates dendritic spines through microtubule end binding proteinsMolecular Psychiatry2014111
15APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory SynapsesCell Reports2014109
16Identification and functional characterization of indole-3-acetamide-mediated IAA biosynthesis in plant-associated Fusarium speciesFungal Genetics and Biology2012108
17Emergence and Transmission of Arbovirus Evolutionary Intermediates with Epidemic PotentialCell Host and Microbe2014107
18Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling statesELife2014105
19BcXYG1, a Secreted Xyloglucanase from Botrytis cinerea, Triggers Both Cell Death and Plant Immune ResponsesPlant Physiology2017102
20ConSurf‐DB: An accessible repository for the evolutionary conservation patterns of the majority of PDB proteinsProtein Science202098
21Genetic and Mechanical Regulation of Intestinal Smooth Muscle DevelopmentCell201995
22Functional evaluation of autism-associated mutations in NHE9Nature Communications201387
23Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITFMolecular Cell201585
24DDGun: an untrained method for the prediction of protein stability changes upon single and multiple point variationsBMC Bioinformatics201981
25CHAPERONIN 20 mediates iron superoxide dismutase (FeSOD) activity independent of its co‐chaperonin role in Arabidopsis chloroplastsNew Phytologist201376
26GroEL and CCT are catalytic unfoldases mediating out-of-cage polypeptide refolding without ATPProceedings of the National Academy of Sciences of the United States of America201375
27Targeting Macrophage Subsets for Infarct RepairJournal of Cardiovascular Pharmacology and Therapeutics201575
28Broad phylogenetic analysis of cation/proton antiporters reveals transport determinantsNature Communications201874
29New Model of Cystic Fibrosis Transmembrane Conductance Regulator Proposes Active Channel-like ConformationJournal of Chemical Information and Modeling201273
30Using evolutionary data to make sense of macromolecules with a “face‐lifted” ConSurfProtein Science202373
31A Multilaboratory Comparison of Calibration Accuracy and the Performance of External References in Analytical UltracentrifugationPLoS ONE201571
32Aberrant expression of c-Jun in glioblastoma by internal ribosome entry site (IRES)-mediated translational activationProceedings of the National Academy of Sciences of the United States of America201270
33Global view of the protein universeProceedings of the National Academy of Sciences of the United States of America201469
34Crystal structures of virus-like photosystem I complexes from the mesophilic cyanobacterium Synechocystis PCC 6803ELife201369
35The Bacterial Quorum-Sensing Signal Molecule N-3-Oxo-Dodecanoyl-l-Homoserine Lactone Reciprocally Modulates Pro- and Anti-Inflammatory Cytokines in Activated MacrophagesJournal of Immunology201367
36Structure and function of photosystem I in Cyanidioschyzon merolaePhotosynthesis Research201965
37Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERADMolecular Biology of the Cell201464
38On the emergence of P-Loop NTPase and Rossmann enzymes from a Beta-Alpha-Beta ancestral fragmentELife202061
39Peptide-guided nanoparticles for glioblastoma targetingJournal of Controlled Release201960
40A structural model of the copper ATPase ATP7B to facilitate analysis of Wilson disease-causing mutations and studies of the transport mechanismMetallomics201256
41Interactions of the GnRH receptor with heterotrimeric G proteinsFrontiers in Neuroendocrinology201353
42Protein stability: a single recorded mutation aids in predicting the effects of other mutations in the same amino acid siteBioinformatics201151
43Ubiquitylation‐dependent oligomerization regulates activity of Nedd4 ligasesEMBO Journal201751
44Direct Interaction of Mitochondrial Targeting Presequences with Purified Components of the TIM23 Protein ComplexJournal of Biological Chemistry201150
45The complexity of chloroplast chaperoninsTrends in Plant Science201350
46Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemiaBlood201450
47Cα-trace model of the transmembrane domain of human copper transporter 1, motion and functional implicationsProceedings of the National Academy of Sciences of the United States of America201048
48Synthetic biology approach to reconstituting the ubiquitylation cascade in bacteriaEMBO Journal201247
49Competition of calcified calmodulin N lobe and PIP 2 to an LQT mutation site in Kv7.1 channelProceedings of the National Academy of Sciences of the United States of America201746
50Structure of the plant photosystem IBiochemical Society Transactions201846