| The role of dynamic conformational ensembles in biomolecular recognition | Nature Chemical Biology | 2009 | 1.4K |
| Chromatin organization marks exon-intron structure | Nature Structural and Molecular Biology | 2009 | 469 |
| The origin of allosteric functional modulation: multiple pre-existing pathways | Structure | 2009 | 309 |
| The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 280 |
| Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations | American Journal of Human Genetics | 2009 | 275 |
| Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant | Annals of Human Genetics | 2009 | 181 |
| Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder | American Journal of Human Genetics | 2009 | 175 |
| Hearing loss: mechanisms revealed by genetics and cell biology | Annual Review of Genetics | 2009 | 153 |
| MicroRNAs are essential for development and function of inner ear hair cells in vertebrates | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 151 |
| The insulin-like growth factor-I receptor as an oncogene | Archives of Physiology and Biochemistry | 2009 | 144 |
| Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells | Diabetes/Metabolism Research and Reviews | 2009 | 135 |
| Protein-protein interaction networks: how can a hub protein bind so many different partners? | Trends in Biochemical Sciences | 2009 | 111 |
| Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK | EMBO Journal | 2009 | 110 |
| Activation of ATM depends on chromatin interactions occurring before induction of DNA damage | Nature Cell Biology | 2009 | 108 |
| NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model | Neurobiology of Disease | 2009 | 103 |
| Epithelial-mesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic beta cells | PLoS ONE | 2009 | 96 |
| Pax6 is essential for lens fiber cell differentiation | Development (Cambridge) | 2009 | 91 |
| Polymorphism of Alzheimer's Abeta17-42 (p3) oligomers: the importance of the turn location and its conformation | Biophysical Journal | 2009 | 88 |
| Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice | Journal of Neuroscience | 2009 | 87 |
| Theoretical characterization of substrate access/exit channels in the human cytochrome P450 3A4 enzyme: involvement of phenylalanine residues in the gating mechanism | Journal of Physical Chemistry B | 2009 | 87 |
| Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels | Biophysical Journal | 2009 | 84 |
| Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis | Development (Cambridge) | 2009 | 83 |
| The fetal cerebellum. Pitfalls in diagnosis and management | Prenatal Diagnosis | 2009 | 79 |
| Addressing Alzheimer's disease tangles: from NAP to AL-108 | Current Alzheimer Research | 2009 | 78 |
| Research ethics. Children and population biobanks | Science | 2009 | 73 |
