| # | Title | Journal | Year | Citations |
|---|
| 1 | Thrombospondins Are Astrocyte-Secreted Proteins that Promote CNS Synaptogenesis | Cell | 2005 | 1,427 |
| 2 | Basic and clinical aspects of visceral hyperalgesia | Gastroenterology | 1994 | 875 |
| 3 | Nitric oxide (NO) and nociceptive processing in the spinal cord | Pain | 1993 | 854 |
| 4 | Chronic pain and medullary descending facilitation | Trends in Neurosciences | 2002 | 843 |
| 5 | The Lutropin/Choriogonadotropin Receptor, A 2002 Perspective | Endocrine Reviews | 2002 | 671 |
| 6 | Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudaffective reflexes in the rat | Brain Research | 1988 | 636 |
| 7 | Descending modulation of pain | Neuroscience and Biobehavioral Reviews | 2004 | 503 |
| 8 | BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions | Cell | 2012 | 481 |
| 9 | Supraspinal contributions to hyperalgesia | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 479 |
| 10 | The Anesthetic Properties of Xenon in Animals and Human Beings, with Additional Observations on Krypton | Science | 1951 | 384 |
| 11 | Interactions between cardiovascular and pain regulatory systems | Neuroscience and Biobehavioral Reviews | 1984 | 379 |
| 12 | Localization of cardiac L-type Ca2+ channels to a caveolar macromolecular signaling complex is required for beta2-adrenergic regulation | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 369 |
| 13 | Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat | Neuroscience | 1992 | 358 |
| 14 | Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK | Cell Metabolism | 2014 | 342 |
| 15 | CaMKII determines mitochondrial stress responses in heart | Nature | 2012 | 340 |
| 16 | The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat | Neuropharmacology | 1994 | 319 |
| 17 | Supramolecular Assemblies and Localized Regulation of Voltage-Gated Ion Channels | Physiological Reviews | 2009 | 309 |
| 18 | Human UGT2B7 catalyzes morphine glucuronidation | Drug Metabolism and Disposition | 1997 | 309 |
| 19 | Astrocytes, Not Neurons, Produce Docosahexaenoic Acid (22:6?-3) and Arachidonic Acid (20:4?-6) | Journal of Neurochemistry | 1991 | 308 |
| 20 | The cellular and molecular bases of leptin and ghrelin resistance in obesity | Nature Reviews Endocrinology | 2017 | 304 |
| 21 | Drug Metabolism in the Newborn Rabbit | Science | 1959 | 297 |
| 22 | Receptor binding properties of human and animal H1 influenza virus isolates | Virology | 1989 | 293 |
| 23 | Acetaminophen elimination kinetics in neonates, children, and adults | Clinical Pharmacology and Therapeutics | 1976 | 277 |
| 24 | Acetylation-Deacetylation of the Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-related Factor 2) Regulates Its Transcriptional Activity and Nucleocytoplasmic Localization | Journal of Biological Chemistry | 2011 | 268 |
| 25 | Nucleophosmin (B23) Targets ARF to Nucleoli and Inhibits Its Function | Molecular and Cellular Biology | 2005 | 264 |
| 26 | The t(8;21) fusion protein, AML1–ETO, specifically represses the transcription of the p14ARF tumor suppressor in acute myeloid leukemia | Nature Medicine | 2002 | 258 |
| 27 | NS21: Re-defined and modified supplement B27 for neuronal cultures | Journal of Neuroscience Methods | 2008 | 258 |
| 28 | p53 Acetylation: Regulation and Consequences | Cancers | 2015 | 256 |
| 29 | Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for N-methyl-D-aspartate-produced facilitation of the nociceptive tail-flick reflex | European Journal of Pharmacology | 1992 | 254 |
| 30 | Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites | ELife | 2015 | 252 |
| 31 | mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1 | Molecular Cell | 2017 | 249 |
| 32 | Evaluation of the periaqueductal central gray (PAG) as a morphine-specific locus of action and examination of morphine-induced and stimulation-produced analgesia at coincident PAG loci | Brain Research | 1977 | 232 |
| 33 | Mechanosensitive properties of pelvic nerve afferent fibers innervating the urinary bladder of the rat | Journal of Neurophysiology | 1994 | 232 |
| 34 | A critical review of the afferent pathways and the potential chemical mediators involved in cardiac pain | Neuroscience | 1992 | 230 |
| 35 | Biphasic Modulation of Spinal Nociceptive Transmission From the Medullary Raphe Nuclei in the Rat | Journal of Neurophysiology | 1997 | 229 |
| 36 | UDP-glucuronosyltransferases: a family of detoxifying enzymes | Trends in Pharmacological Sciences | 1990 | 228 |
| 37 | The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat | Neuroscience | 1994 | 225 |
| 38 | The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268) | Drug Metabolism and Disposition | 1998 | 220 |
| 39 | The toxicity of methanol | Life Sciences | 1991 | 215 |
| 40 | CaMKII binding to GluN2B is critical during memory consolidation | EMBO Journal | 2012 | 207 |
| 41 | Comparison of the biochemical alterations elicited in livers from rats treated with carbon tetrachloride, chloroform, 1,1,2-trichloroethaneand 1,1,1-trichloroethane | Biochemical Pharmacology | 1969 | 202 |
| 42 | Relative effects of various chlorinated hydrocarbons on liver and kidney function in mice | Toxicology and Applied Pharmacology | 1966 | 198 |
| 43 | Methanol poisoning: Ocular toxicity produced by formate | Toxicology and Applied Pharmacology | 1978 | 195 |
| 44 | Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance | Cell Reports | 2014 | 195 |
| 45 | Characterization of coeruleospinal inhibition of the nociceptive tail-flick reflex in the rat: Mediation by spinal α2-adrenoceptors | Brain Research | 1986 | 193 |
| 46 | mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 193 |
| 47 | Characterization of inhibition of a spinal nociceptive reflex by stimulation medially and laterally in the midbrain and medulla in the pentobarbital-anesthetized rat | Brain Research | 1984 | 191 |
| 48 | PKA/AKAP1 and PP2A/Bβ2 Regulate Neuronal Morphogenesis via Drp1 Phosphorylation and Mitochondrial Bioenergetics | Journal of Neuroscience | 2011 | 179 |
| 49 | Characterization of Aδ- and C-Fibers Innervating the Plantar Rat Hindpaw One Day After an Incision | Journal of Neurophysiology | 2002 | 178 |
| 50 | Methanol poisoning I. The role of formic acid in the development of metabolic acidosis in the monkey and the reversal by 4-methylpyrazole | Biochemical Medicine | 1975 | 176 |
