| # | Title | Journal | Year | Citations |
|---|
| 1 | CpG motifs in bacterial DNA trigger direct B-cell activation | Nature | 1995 | 3,329 |
| 2 | Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice | Cell Host and Microbe | 2016 | 1,284 |
| 3 | Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization | Developmental Cell | 2008 | 992 |
| 4 | Epidemiology of Invasive Mycoses in North America | Critical Reviews in Microbiology | 2010 | 799 |
| 5 | Post-translational disruption of dystroglycan–ligand interactions in congenital muscular dystrophies | Nature | 2002 | 747 |
| 6 | Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection | Journal of Immunology | 2017 | 718 |
| 7 | Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs | Science | 2008 | 686 |
| 8 | Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls | Scientific Reports | 2016 | 660 |
| 9 | Laryngeal Cancer in the United States: Changes in Demographics, Patterns of Care, and Survival | Laryngoscope | 2006 | 652 |
| 10 | Rare and Emerging Opportunistic Fungal Pathogens: Concern for Resistance beyondCandida albicansandAspergillus fumigatus | Journal of Clinical Microbiology | 2004 | 623 |
| 11 | Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors | Nature Biotechnology | 2009 | 536 |
| 12 | Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy | Nature | 2002 | 532 |
| 13 | PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53 | Science | 2005 | 500 |
| 14 | Shaping and reshaping CD8+ T-cell memory | Nature Reviews Immunology | 2008 | 493 |
| 15 | Airway Memory CD4 + T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses | Immunity | 2016 | 468 |
| 16 | IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes | Journal of Clinical Investigation | 2019 | 460 |
| 17 | Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection | Nature Immunology | 2012 | 438 |
| 18 | Bacterial Pathogens Isolated from Patients with Bloodstream Infection: Frequencies of Occurrence and Antimicrobial Susceptibility Patterns from the SENTRY Antimicrobial Surveillance Program (United States and Canada, 1997) | Antimicrobial Agents and Chemotherapy | 1998 | 422 |
| 19 | Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers | International Journal of Cancer | 2004 | 418 |
| 20 | Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth | Science Translational Medicine | 2010 | 416 |
| 21 | Virus-Specific Memory CD8 T Cells Provide Substantial Protection from Lethal Severe Acute Respiratory Syndrome Coronavirus Infection | Journal of Virology | 2014 | 407 |
| 22 | Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment | Cell | 2020 | 398 |
| 23 | COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice | Nature | 2021 | 394 |
| 24 | The Prognostic Value of Tumor Blood Vessel Morphology in Primary Uveal Melanoma | Ophthalmology | 1993 | 384 |
| 25 | Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis | Cell | 2012 | 377 |
| 26 | Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx | International Journal of Cancer | 2003 | 365 |
| 27 | In Vitro Susceptibility of Invasive Isolates of Candida spp. to Anidulafungin, Caspofungin, and Micafungin: Six Years of Global Surveillance | Journal of Clinical Microbiology | 2008 | 363 |
| 28 | Membranoproliferative Glomerulonephritis Type II (Dense Deposit Disease) | Journal of the American Society of Nephrology: JASN | 2005 | 354 |
| 29 | CaMKII determines mitochondrial stress responses in heart | Nature | 2012 | 340 |
| 30 | Epidemiology and Outcomes of Invasive Candidiasis Due to Non-albicans Species of Candida in 2,496 Patients: Data from the Prospective Antifungal Therapy (PATH) Registry 2004–2008 | PLoS ONE | 2014 | 338 |
| 31 | Alcohol Abuse, Alcoholism, and Damage to the Immune System—A Review | Alcoholism: Clinical and Experimental Research | 1998 | 335 |
| 32 | Twelve years of fluconazole in clinical practice: global trends in species distribution and fluconazole susceptibility of bloodstream isolates of Candida | Clinical Microbiology and Infection | 2004 | 333 |
| 33 | National Surveillance of Nosocomial Blood Stream Infection Due to Species of Candida Other than Candida albicans: Frequency of Occurrence and Antifungal Susceptibility in the SCOPE Program | Diagnostic Microbiology and Infectious Disease | 1998 | 331 |
| 34 | Defining Memory CD8 T Cell | Frontiers in Immunology | 2018 | 313 |
| 35 | Astrocytes, Not Neurons, Produce Docosahexaenoic Acid (22:6?-3) and Arachidonic Acid (20:4?-6) | Journal of Neurochemistry | 1991 | 308 |
| 36 | Efficient Detection and Long-Term Persistence of the Carriage of Methicillin-Resistant Staphylococcus aureus | Clinical Infectious Diseases | 1994 | 304 |
| 37 | National Surveillance of Nosocomial Blood Stream Infection Due to Candida albicans: Frequency of Occurrence and Antifungal Susceptibility in the SCOPE Program | Diagnostic Microbiology and Infectious Disease | 1998 | 292 |
| 38 | Trends in Antifungal Susceptibility of Candida spp. Isolated from Pediatric and Adult Patients with Bloodstream Infections: SENTRY Antimicrobial Surveillance Program, 1997 to 2000 | Journal of Clinical Microbiology | 2002 | 290 |
| 39 | The changing epidemiology of healthcare-associated candidemia over three decades | Diagnostic Microbiology and Infectious Disease | 2012 | 278 |
| 40 | SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2 | Cell Research | 2016 | 261 |
| 41 | Airway acidification initiates host defense abnormalities in cystic fibrosis mice | Science | 2016 | 254 |
| 42 | LARGE can functionally bypass α-dystroglycan glycosylation defects in distinct congenital muscular dystrophies | Nature Medicine | 2004 | 253 |
| 43 | In Vitro Activity of Two Echinocandin Derivatives, LY303366 and MK-0991 (L-743,792), Against Clinical Isolates of Aspergillus, Fusarium, Rhizopus, and Other Filamentous Fungi | Diagnostic Microbiology and Infectious Disease | 1998 | 252 |
| 44 | Recovery from the Middle East respiratory syndrome is associated with antibody and T cell responses | Science Immunology | 2017 | 252 |
| 45 | Sarcolemma-localized nNOS is required to maintain activity after mild exercise | Nature | 2008 | 251 |
| 46 | Opa1-Mediated Cristae Opening Is Bax/Bak and BH3 Dependent, Required for Apoptosis, and Independent of Bak Oligomerization | Molecular Cell | 2008 | 248 |
| 47 | Survey of Bloodstream Infections Due to Gram-Negative Bacilli: Frequency of Occurrence and Antimicrobial Susceptibility of Isolates Collected in the United States, Canada, and Latin America for the SENTRY Antimicrobial Surveillance Program, 1997 | Clinical Infectious Diseases | 1999 | 241 |
| 48 | THE INHIBITION OF BLOOD CLOTTING: AN UNIDENTIFIED SUBSTANCE WHICH ACTS IN CONJUNCTION WITH HEPARIN TO PREVENT THE CONVERSION OF PROTHROMBIN INTO THROMBIN | American Journal of Physiology | 1939 | 239 |
| 49 | Myelodysplastic syndromes. A clinical and pathologic analysis of 109 cases | Cancer | 1985 | 238 |
| 50 | Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation | Cell | 2022 | 237 |
