| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage | Nature | 2000 | 3,895 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 4 | Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial | Lancet, The | 2009 | 2,762 |
| 5 | Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis | Cell | 1993 | 1,383 |
| 6 | RNA polymerase III transcribes human microRNAs | Nature Structural and Molecular Biology | 2006 | 1,200 |
| 7 | Transvascular delivery of small interfering RNA to the central nervous system | Nature | 2007 | 1,122 |
| 8 | Demonstration that CFTR is a chloride channel by alteration of its anion selectivity | Science | 1991 | 1,103 |
| 9 | Outcomes in refractory diffuse large B-cell lymphoma: results from the international SCHOLAR-1 study | Blood | 2017 | 1,084 |
| 10 | Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide | Nature | 1990 | 998 |
| 11 | A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation | Cell | 2008 | 951 |
| 12 | Neuroprotection in Ischemia | Cell | 2004 | 948 |
| 13 | Idiopathic Pulmonary Fibrosis | New England Journal of Medicine | 2001 | 911 |
| 14 | Comparison and Evaluation of Methods for Liver Segmentation From CT Datasets | IEEE Transactions on Medical Imaging | 2009 | 848 |
| 15 | Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells | European Journal of Immunology | 2001 | 790 |
| 16 | The Nalp3 inflammasome is essential for the development of silicosis | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 765 |
| 17 | Guidelines of the Pituitary Society for the diagnosis and management of prolactinomas | Clinical Endocrinology | 2006 | 720 |
| 18 | Obesity-Associated Hypertension | Hypertension | 2005 | 688 |
| 19 | Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs | Science | 2008 | 686 |
| 20 | Current prospects for RNA interference-based therapies | Nature Reviews Genetics | 2011 | 674 |
| 21 | Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2′,7′-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2′,7′-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123 | Free Radical Biology and Medicine | 1999 | 673 |
| 22 | Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein | Nature | 2009 | 666 |
| 23 | Initiation and perpetuation of NLRP3 inflammasome activation and assembly | Immunological Reviews | 2015 | 651 |
| 24 | Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells | Nature | 1990 | 649 |
| 25 | Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1 | Nature Immunology | 2012 | 649 |
| 26 | Hospital-Acquired Candidemia | Archives of Internal Medicine | 1988 | 639 |
| 27 | The Acid-Activated Ion Channel ASIC Contributes to Synaptic Plasticity, Learning, and Memory | Neuron | 2002 | 638 |
| 28 | The joint IAEA, EANM, and SNMMI practical guidance on peptide receptor radionuclide therapy (PRRNT) in neuroendocrine tumours | European Journal of Nuclear Medicine and Molecular Imaging | 2013 | 633 |
| 29 | RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 626 |
| 30 | Motile Cilia of Human Airway Epithelia Are Chemosensory | Science | 2009 | 618 |
| 31 | The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease | Journal of Neuroscience | 2008 | 616 |
| 32 | Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities | Antioxidants and Redox Signaling | 2010 | 600 |
| 33 | Superoxide Production in Vascular Smooth Muscle Contributes to Oxidative Stress and Impaired Relaxation in Atherosclerosis | Circulation Research | 1998 | 597 |
| 34 | Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 593 |
| 35 | CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 569 |
| 36 | Self-generated diversity produces “insurance effects” in biofilm communities | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 569 |
| 37 | Mechanism of NLRP3 inflammasome activation | Annals of the New York Academy of Sciences | 2014 | 569 |
| 38 | Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells | Journal of Immunology | 2000 | 567 |
| 39 | Delineation of a CpG Phosphorothioate Oligodeoxynucleotide for Activating Primate Immune Responses In Vitro and In Vivo | Journal of Immunology | 2000 | 550 |
| 40 | Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors | Nature Biotechnology | 2009 | 536 |
| 41 | The Pendred syndrome gene encodes a chloride-iodide transport protein | Nature Genetics | 1999 | 524 |
| 42 | Nucleoside triphosphates are required to open the CFTR chloride channel | Cell | 1991 | 519 |
| 43 | Dystroglycan: from biosynthesis to pathogenesis of human disease | Journal of Cell Science | 2006 | 511 |
| 44 | Glycosaminoglycan-protein interactions: definition of consensus sites in glycosaminoglycan binding proteins | BioEssays | 1998 | 502 |
| 45 | Nicotinamide riboside is uniquely and orally bioavailable in mice and humans | Nature Communications | 2016 | 498 |
| 46 | Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. | Journal of Clinical Investigation | 1990 | 491 |
| 47 | Understanding the coronary circulation through studies at the microvascular level. | Circulation | 1990 | 490 |
| 48 | Thin Filament-Mediated Regulation of Cardiac Contraction | Annual Review of Physiology | 1996 | 489 |
| 49 | Minireview: Overview of the Renin-Angiotensin System—An Endocrine and Paracrine System | Endocrinology | 2003 | 484 |
| 50 | Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 479 |
