| # | Title | Journal | Year | Citations |
|---|
| 1 | Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II) | Lancet, The | 1998 | 3,216 |
| 2 | Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials | Lancet, The | 2010 | 1,871 |
| 3 | Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage | Neurology | 2006 | 992 |
| 4 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial | Lancet Neurology, The | 2008 | 971 |
| 5 | DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING | Lancet, The | 1989 | 622 |
| 6 | Reduced BDNF mRNA Expression in the Parkinson's Disease Substantia Nigra | Experimental Neurology | 2000 | 404 |
| 7 | Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF | Lancet Neurology, The | 2012 | 310 |
| 8 | Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis | Multiple Sclerosis Journal | 2016 | 284 |
| 9 | Pathophysiological Topography of Acute Ischemia by Combined Diffusion-Weighted and Perfusion MRI | Stroke | 1999 | 280 |
| 10 | Guidelines for imaging infants and children with recent‐onset epilepsy | Epilepsia | 2009 | 238 |
| 11 | Refining the Perfusion–Diffusion Mismatch Hypothesis | Stroke | 2005 | 218 |
| 12 | Anti-epileptic medication and bone health | Osteoporosis International | 2007 | 217 |
| 13 | Impulsive and compulsive behaviors in Parkinson's disease | Movement Disorders | 2009 | 192 |
| 14 | Perihematomal Edema in Primary Intracerebral Hemorrhage Is Plasma Derived | Stroke | 2004 | 181 |
| 15 | Clinical utility of EEG in diagnosing and monitoring epilepsy in adults | Clinical Neurophysiology | 2018 | 178 |
| 16 | Neurological Consequences of Diabetic Ketoacidosis at Initial Presentation of Type 1 Diabetes in a Prospective Cohort Study of Children | Diabetes Care | 2014 | 177 |
| 17 | Magnetic stimulation of the brain in generalized epilepsy: Reversal of cortical hyperexcitability by anticonvulsants | Annals of Neurology | 1993 | 174 |
| 18 | Seizure-associated hippocampal volume loss: A longitudinal magnetic resonance study of temporal lobe epilepsy | Annals of Neurology | 2002 | 172 |
| 19 | Apparent Diffusion Coefficient Threshold for Delineation of Ischemic Core | International Journal of Stroke | 2015 | 160 |
| 20 | Predictors of long‐term disability accrual in relapse‐onset multiple sclerosis | Annals of Neurology | 2016 | 158 |
| 21 | Treatment decisions in multiple sclerosis — insights from real-world observational studies | Nature Reviews Neurology | 2017 | 154 |
| 22 | Stroke Severity Is a Crucial Predictor of Outcome: An International Prospective Validation Study | Journal of the American Heart Association | 2016 | 152 |
| 23 | Pretreatment Diffusion- and Perfusion-MR Lesion Volumes Have a Crucial Influence on Clinical Response to Stroke Thrombolysis | Journal of Cerebral Blood Flow and Metabolism | 2010 | 151 |
| 24 | Comparison of ictal SPECT and interictal PET in the presurgical evaluation of temporal lobe epilepsy | Annals of Neurology | 1995 | 140 |
| 25 | Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial | Lancet Neurology, The | 2019 | 139 |
| 26 | Risk factors for lacunar infarction syndromes | Neurology | 1995 | 132 |
| 27 | Temporal lobe epilepsy in childhood: Clinical, EEG, and neuroimaging findings and syndrome classification in a cohort with new-onset seizures | Neurology | 1997 | 130 |
| 28 | Early Postnatal Stress Confers Enduring Vulnerability to Limbic Epileptogenesis | Epilepsia | 2007 | 130 |
| 29 | Polymicrogyria and deletion 22q11.2 syndrome: Window to the etiology of a common cortical malformation | American Journal of Medical Genetics, Part A | 2006 | 125 |
| 30 | Clinical features, pathogenesis, and computed tomographic characteristics of internal watershed infarction. | Stroke | 1993 | 124 |
| 31 | Multiple Sclerosis Relapses: Epidemiology, Outcomes and Management. A Systematic Review | Neuroepidemiology | 2015 | 124 |
| 32 | SMOKING AS A RISK FACTOR FOR CEREBRAL ISCHAEMIA | Lancet, The | 1989 | 122 |
| 33 | Independent Occurrence of the CHRNA4 Ser248Phe Mutation in a Norwegian Family with Nocturnal Frontal Lobe Epilepsy | Epilepsia | 2000 | 119 |
| 34 | Epilepsy Surgery for Pathologically Proven Hippocampal Sclerosis Provides Long‐term Seizure Control and Improved Quality of Life | Epilepsia | 2004 | 117 |
| 35 | Community-Based Study of Mortality in Children with Epilepsy | Epilepsia | 1993 | 116 |
| 36 | Insular Cortical Ischemia Is Independently Associated With Acute Stress Hyperglycemia | Stroke | 2004 | 114 |
| 37 | Familial partial epilepsy with variable foci: A new partial epilepsy syndrome with suggestion of linkage to chromosome 2 | Annals of Neurology | 1998 | 111 |
| 38 | Video analysis of acute motor and convulsive manifestations in sport-related concussion | Neurology | 2000 | 110 |
| 39 | Risk Factors for Stroke Due to Cerebral Infarction in Young Adults | Stroke | 1997 | 103 |
| 40 | Clinical-Diffusion Mismatch Predicts the Putative Penumbra With High Specificity | Stroke | 2005 | 101 |
| 41 | Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau | Brain | 2016 | 100 |
| 42 | Chromosomal Abnormalities and Epilepsy: A Review for Clinicians and Gene Hunters | Epilepsia | 2002 | 98 |
| 43 | Men may be more vulnerable to seizure-associated brain damage | Neurology | 2000 | 95 |
| 44 | Poststroke Chronic Disease Management: Towards Improved Identification and Interventions for Poststroke Spasticity-Related Complications | International Journal of Stroke | 2011 | 94 |
| 45 | Selection of thrombolytic therapy beyond 3 h using magnetic resonance imaging | Current Opinion in Neurology | 2005 | 88 |
| 46 | Ictal 99mTc-HMPAO Single Photon Emission Computed Tomography in Children with Temporal Lobe Epilepsy | Epilepsia | 1993 | 85 |
| 47 | Effect of antiepileptic medication on bone mineral measures: | Neurology | 2005 | 85 |
| 48 | Natural history of pulmonary function in collagen VI-related myopathies | Brain | 2013 | 85 |
| 49 | “Pressure to laugh”: An unusual epileptic symptom associated with small hypothalamic hamartomas | Neurology | 2000 | 82 |
| 50 | Rapid Assessment of Perfusion–Diffusion Mismatch | Stroke | 2008 | 81 |
