| # | Title | Journal | Year | Citations |
|---|
| 1 | ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology | Epilepsia | 2017 | 3,464 |
| 2 | Hyaluronan 1 | FASEB Journal | 1992 | 1,911 |
| 3 | Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis | Lancet Oncology, The | 2011 | 1,467 |
| 4 | Adipose tissue as an endocrine organ | Molecular and Cellular Endocrinology | 2010 | 1,345 |
| 5 | A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression | Science | 1987 | 1,304 |
| 6 | 1,026 Experimental treatments in acute stroke | Annals of Neurology | 2006 | 1,238 |
| 7 | Colony-stimulating factors in inflammation and autoimmunity | Nature Reviews Immunology | 2008 | 1,111 |
| 8 | Proteoglycans: many forms and many functions | FASEB Journal | 1992 | 1,101 |
| 9 | Telomere dysfunction induces metabolic and mitochondrial compromise | Nature | 2011 | 1,093 |
| 10 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 11 | Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer | Journal of Cellular Physiology | 2005 | 1,046 |
| 12 | Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer | Science Translational Medicine | 2016 | 1,036 |
| 13 | Protein kinase C contains a pseudosubstrate prototope in its regulatory domain | Science | 1987 | 1,022 |
| 14 | Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs | JAMA Neurology | 2018 | 910 |
| 15 | Depression and cardiovascular disease: a clinical review | European Heart Journal | 2014 | 861 |
| 16 | Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline | Endoscopy | 2017 | 831 |
| 17 | Long-Term Effect of Goal-Directed Weight Management in an Atrial Fibrillation Cohort | Journal of the American College of Cardiology | 2015 | 738 |
| 18 | Aggressive Risk Factor Reduction Study for Atrial Fibrillation and Implications for the Outcome of Ablation | Journal of the American College of Cardiology | 2014 | 737 |
| 19 | Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease | Annals of Neurology | 2011 | 730 |
| 20 | The role of the gut microbiota in NAFLD | Nature Reviews Gastroenterology and Hepatology | 2016 | 728 |
| 21 | The Health Education Impact Questionnaire (heiQ): An outcomes and evaluation measure for patient education and self-management interventions for people with chronic conditions | Patient Education and Counseling | 2007 | 724 |
| 22 | A Comparison of Omeprazole with Ranitidine for Ulcers Associated with Nonsteroidal Antiinflammatory Drugs | New England Journal of Medicine | 1998 | 723 |
| 23 | Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study | Lancet, The | 2010 | 715 |
| 24 | Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase | Diabetes | 2006 | 699 |
| 25 | Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2. | Proceedings of the National Academy of Sciences of the United States of America | 1989 | 697 |
| 26 | The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase | Science | 2012 | 649 |
| 27 | Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes | European Heart Journal | 2012 | 642 |
| 28 | Evaluating the glucose tolerance test in mice | American Journal of Physiology - Endocrinology and Metabolism | 2008 | 635 |
| 29 | Continued Breast Cancer Risk Reduction in Postmenopausal Women Treated with Raloxifene: 4-Year Results from the MORE Trial | Breast Cancer Research and Treatment | 2001 | 629 |
| 30 | DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING | Lancet, The | 1989 | 622 |
| 31 | Electrical Remodeling of the Atria in Congestive Heart Failure | Circulation | 2003 | 593 |
| 32 | Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1 | Nature Genetics | 2013 | 589 |
| 33 | The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury? | Kidney International | 1999 | 566 |
| 34 | Activated Macrophages and Microglia Induce Dopaminergic Sprouting in the Injured Striatum and Express Brain-Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor | Journal of Neuroscience | 1999 | 546 |
| 35 | Epilepsy | Nature Reviews Disease Primers | 2018 | 541 |
| 36 | Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit | BoneKEy Reports | 2014 | 536 |
| 37 | Epileptology of the first-seizure presentation: a clinical, electroencephalographic, and magnetic resonance imaging study of 300 consecutive patients | Lancet, The | 1998 | 532 |
| 38 | Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer | Annals of Oncology | 2015 | 517 |
| 39 | Reactive Oxygen Species Enhance Insulin Sensitivity | Cell Metabolism | 2009 | 509 |
| 40 | Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma | Leukemia | 2010 | 505 |
| 41 | Extensions to multivariate normal models for pedigree analysis | Annals of Human Genetics | 1982 | 502 |
| 42 | Breast Cancer Cells Interact with Osteoblasts to Support Osteoclast Formation1 | Endocrinology | 1999 | 497 |
| 43 | Exercise Before Puberty May Confer Residual Benefits in Bone Density in Adulthood: Studies in Active Prepubertal and Retired Female Gymnasts | Journal of Bone and Mineral Research | 1998 | 496 |
| 44 | A Microenvironment-Induced Myeloproliferative Syndrome Caused by Retinoic Acid Receptor γ Deficiency | Cell | 2007 | 490 |
| 45 | Effects of Fenofibrate Treatment on Cardiovascular Disease Risk in 9,795 Individuals With Type 2 Diabetes and Various Components of the Metabolic Syndrome | Diabetes Care | 2009 | 488 |
| 46 | Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection | Nature Immunology | 2022 | 486 |
| 47 | Butyrate production from dietary fibre and protection against large bowel cancer in a rat model. | Gut | 1993 | 484 |
| 48 | HSP72 protects against obesity-induced insulin resistance | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 477 |
| 49 | Pathogenesis, prevention, and treatment of diabetic nephropathy | Lancet, The | 1998 | 476 |
| 50 | Crohn's disease management after intestinal resection: a randomised trial | Lancet, The | 2015 | 475 |
