157(top 1%)
papers
10.0K(top 1%)
citations
49(top 1%)
h-index
99(top 1%)
g-index
167
all documents
11.1K
doc citations
1.8K
citing journals

Top Articles

#TitleJournalYearCitations
1Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitorsScience20202,527
2Nsp3 of coronaviruses: Structures and functions of a large multi-domain proteinAntiviral Research2018542
3From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug designFEBS Journal2014537
4α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity AssessmentJournal of Medicinal Chemistry2020437
5Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1Nature Medicine2012405
6Structure and functionality in flavivirus NS-proteins: Perspectives for drug designAntiviral Research2010289
7Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitorScience2016285
8Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancerEMBO Journal2006241
9The battle for chitin recognition in plant-microbe interactionsFEMS Microbiology Reviews2015238
10Fungal effector Ecp6 outcompetes host immune receptor for chitin binding through intrachain LysM dimerizationELife2013217
11pH-dependent Conformational Flexibility of the SARS-CoV Main Proteinase (Mpro) Dimer: Molecular Dynamics Simulations and Multiple X-ray Structure AnalysesJournal of Molecular Biology2005175
12p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PL pro via E3 ubiquitin ligase RCHY1Proceedings of the National Academy of Sciences of the United States of America2016172
13The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-QuadruplexesPLoS Pathogens2009156
14Megahertz serial crystallographyNature Communications2018147
15Molecular Basis for Recognition of Dilysine Trafficking Motifs by COPIDevelopmental Cell2012123
16Microbiome manipulation by a soil-borne fungal plant pathogen using effector proteinsNature Plants2020118
17Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main proteaseAntiviral Research2011112
18A G-quadruplex-binding macrodomain within the “SARS-unique domain” is essential for the activity of the SARS-coronavirus replication–transcription complexVirology2015112
19Structural and Functional Characterization of Falcipain-2, a Hemoglobinase from the Malarial Parasite Plasmodium falciparumJournal of Biological Chemistry2006109
20Tolerance induction with T cell–dependent protein antigens induces regulatory sialylated IgGsJournal of Allergy and Clinical Immunology2012107
21Peptide–Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural BiologyJournal of Medicinal Chemistry2017105
22Architecture and regulation of HtrA-family proteins involved in protein quality control and stress responseCellular and Molecular Life Sciences201399
23The Translocated Salmonella Effector Proteins SseF and SseG Interact and Are Required To Establish an Intracellular Replication NicheInfection and Immunity200698
243C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against PicornavirusesJournal of Virology201391
25Processing of the SARS-CoV pp1a/ab nsp7–10 regionBiochemical Journal202090
26Chlamydia pneumoniaedirectly interferes with HIF-1α stabilization in human host cellsCellular Microbiology200789
27A Structural View of the Inactivation of the SARS Coronavirus Main Proteinase by Benzotriazole EstersChemistry and Biology200879
28Picornavirus non-structural proteins as targets for new anti-virals with broad activityAntiviral Research201176
29Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3Developmental Biology200975
30Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site featuresAntiviral Research201474
31Nonstructural Proteins 7 and 8 of Feline Coronavirus Form a 2:1 Heterotrimer That Exhibits Primer-Independent RNA Polymerase ActivityJournal of Virology201273
32Molecular Insights into Vesicle Tethering at the Golgi by the Conserved Oligomeric Golgi (COG) Complex and the Golgin TATA Element Modulatory Factor (TMF)Journal of Biological Chemistry201372
33Hypoxia-Inducible Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (HIF-1β): Is It a Rare Exception?Molecular Medicine201469
34Identification of Novel Falcipain-2 Inhibitors as Potential Antimalarial Agents through Structure-Based Virtual ScreeningJournal of Medicinal Chemistry200968
35Structure and Cleavage Specificity of the Chymotrypsin-Like Serine Protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)Journal of Molecular Biology200966
36Hypoxia abrogates antichlamydial properties of IFN-γ in human fallopian tube cells in vitro and ex vivoProceedings of the National Academy of Sciences of the United States of America201066
37Sensitized Detection of Inhibitory Fragments and Iterative Development of Non‐Peptidic Protease Inhibitors by Dynamic Ligation ScreeningAngewandte Chemie - International Edition200864
38RNA‐virus proteases counteracting host innate immunityFEBS Letters201764
39Development and Characterization of New Peptidomimetic Inhibitors of the West Nile Virus NS2B–NS3 ProteaseChemMedChem201363
40Curcumin Decreases Survival of Hep3B Liver and MCF-7 Breast Cancer CellsStrahlentherapie Und Onkologie201162
41Recent Advances in Neuraminidase Inhibitor Development as Anti‐influenza DrugsChemMedChem201262
42Exoerythrocytic Plasmodium Parasites Secrete a Cysteine Protease Inhibitor Involved in Sporozoite Invasion and Capable of Blocking Cell Death of Host HepatocytesPLoS Pathogens201061
43The Capsid Binder Vapendavir and the Novel Protease Inhibitor SG85 Inhibit Enterovirus 71 ReplicationAntimicrobial Agents and Chemotherapy201460
44Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization modeProtein and Cell201058
45Antiviral strategies to control calicivirus infectionsAntiviral Research201055
46Crystal Structure of the Peroxo-diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in HypusinationStructure201555
47Controlling the Gatekeeper: Therapeutic Targeting of Nuclear TransportCells201855
48Protein crystallization in living cellsBiological Chemistry201855
49Multiple Rieske proteins in prokaryotes: Where and why?Biochimica Et Biophysica Acta - Bioenergetics200554
50Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68Antimicrobial Agents and Chemotherapy201554