| # | Title | Journal | Year | Citations |
|---|
| 1 | Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease | Nature Genetics | 2008 | 2,422 |
| 2 | Somatostatin and Its Receptor Family | Frontiers in Neuroendocrinology | 1999 | 1,440 |
| 3 | MICRODETERMINATION OF OXYHEMOGLOBIN, METHEMOGLOBIN, AND SULFHEMOGLOBIN IN A SINGLE SAMPLE OF BLOOD | Journal of Biological Chemistry | 1938 | 1,051 |
| 4 | The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent Insights | Endocrine Reviews | 2007 | 902 |
| 5 | The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease | BMJ: British Medical Journal | 2008 | 825 |
| 6 | The Development of Large Immature Mononuclear Cells in Mixed Leukocyte Cultures | Blood | 1964 | 488 |
| 7 | Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease | Diabetes, Obesity and Metabolism | 2013 | 432 |
| 8 | Reference Values for a Multiple Repetition 6-Minute Walk Test in Healthy Adults Older Than 20 Years | Journal of Cardiopulmonary Rehabilitation and Prevention | 2001 | 429 |
| 9 | Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). | Endocrinology | 1994 | 325 |
| 10 | The somatostatin receptor family | Life Sciences | 1995 | 321 |
| 11 | The Emotional Impact of End-Stage Renal Disease: Importance of Patients' Perceptions of Intrusiveness and Control | International Journal of Psychiatry in Medicine | 1984 | 308 |
| 12 | A Human-Curated Annotation of the Candida albicans Genome | PLoS Genetics | 2005 | 293 |
| 13 | Myoblast transfer in duchenne muscular dystrophy | Annals of Neurology | 1993 | 291 |
| 14 | The Dual Role of TGFβ in Human Cancer: From Tumor Suppression to Cancer Metastasis | | 2012 | 275 |
| 15 | Comparison of Saliva and Nasopharyngeal Swab Nucleic Acid Amplification Testing for Detection of SARS-CoV-2 | JAMA Internal Medicine | 2021 | 269 |
| 16 | Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis | Diabetes | 1999 | 266 |
| 17 | α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors | Nature Communications | 2013 | 259 |
| 18 | Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34 | Journal of Clinical Investigation | 2005 | 252 |
| 19 | Myocardial infarction patients in the 1990s—their risk factors, stratification and survival in Canada: The Canadian assessment of myocardial infarction (CAMI) study | Journal of the American College of Cardiology | 1996 | 241 |
| 20 | Elevated endothelin-1 in heart failure and loss of normal response to postural change. | Circulation | 1992 | 240 |
| 21 | Scientific problems in clinical scales, as demonstrated in the karnofsky index of performance status | Journal of Chronic Diseases | 1979 | 231 |
| 22 | Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 230 |
| 23 | Initial splanchnic extraction of ingested glucose in normal man | Metabolism: Clinical and Experimental | 1978 | 228 |
| 24 | The risks of death and of severe nonfatal reactions with high- vs low-osmolality contrast media: a meta-analysis. | American Journal of Roentgenology | 1991 | 226 |
| 25 | Transcriptional regulation of nonfermentable carbon utilization in budding yeast | FEMS Yeast Research | 2010 | 221 |
| 26 | Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes mellitus and chronic kidney disease | Diabetes, Obesity and Metabolism | 2014 | 220 |
| 27 | Hepatocyte Growth Factor-induced Scatter of Madin-Darby Canine Kidney Cells Requires Phosphatidylinositol 3-Kinase | Journal of Biological Chemistry | 1995 | 218 |
| 28 | Structural requirements for the growth factor activity of the amino-terminal domain of urokinase. | Journal of Biological Chemistry | 1992 | 214 |
| 29 | Candida albicans Zinc Cluster Protein Upc2p Confers Resistance to Antifungal Drugs and Is an Activator of Ergosterol Biosynthetic Genes | Antimicrobial Agents and Chemotherapy | 2005 | 202 |
| 30 | A Factor stimulating DNA Synthesis derived from the Medium of Leucocyte Cultures | Nature | 1965 | 196 |
| 31 | Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice | American Journal of Physiology - Endocrinology and Metabolism | 2004 | 195 |
| 32 | Denervation Causes Fiber Atrophy and Myosin Heavy Chain Co-Expression in Senescent Skeletal Muscle | PLoS ONE | 2012 | 194 |
| 33 | Multiple Forms of Immunoreactive Somatostatin: Comparison of Distribution in Neural and Nonneural Tissues and Portal Plasma of the Rat* | Endocrinology | 1981 | 193 |
| 34 | Molecular Characterization of a Superoxide-Generating NAD(P)H Oxidase in the Ventilatory Muscles | American Journal of Respiratory and Critical Care Medicine | 2002 | 186 |
| 35 | Aerobic work capacity in patients with chronic fatigue syndrome. | BMJ: British Medical Journal | 1990 | 182 |
| 36 | Peroxide(s) of vanadium : A novel and potent insulin-mimetic agent which activates the insulin receptor kinase | Biochemical and Biophysical Research Communications | 1987 | 179 |
| 37 | Reducing the Lifetime Risk of Cancer From Spinal Radiographs Among People With Adolescent Idiopathic Scoliosis | Spine | 1996 | 178 |
| 38 | Expression of mRNA for all five human somatostatin receptors (hSSTR1-5) in pituitary tumors | Life Sciences | 1994 | 171 |
| 39 | The hairpin stack fold, a novel protein architecture for a new family of protein growth factors | Nature Structural and Molecular Biology | 1996 | 169 |
| 40 | The molecular basis of activity-induced muscle injury in Duchenne muscular dystrophy | | 1998 | 166 |
| 41 | Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus | Nature Genetics | 2012 | 162 |
| 42 | Effect of Obesity on High‐density Lipoprotein Metabolism | Obesity | 2007 | 161 |
| 43 | Agonist-dependent regulation of cloned human somatostatin receptor types 1-5 (hSSTR1-5): subtype selective internalization or upregulation. | Endocrinology | 1996 | 159 |
| 44 | Histone Deacetylase 4 Possesses Intrinsic Nuclear Import and Export Signals | Molecular and Cellular Biology | 2001 | 158 |
| 45 | Structural requirements for the growth factor activity of the amino-terminal domain of urokinase | Journal of Biological Chemistry | 1992 | 158 |
| 46 | Association of the Multisubstrate Docking Protein Gab1 with the Hepatocyte Growth Factor Receptor Requires a Functional Grb2 Binding Site Involving Tyrosine 1356 | Journal of Biological Chemistry | 1997 | 156 |
| 47 | Activin/TGF-β induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP | Nature Cell Biology | 2002 | 153 |
| 48 | The Severe Hypercholesterolemia Phenotype | Journal of the American College of Cardiology | 2014 | 153 |
| 49 | Multiple Gene Transcripts of the Somatostatin Receptor SSTR2: Tissue-Selective Distribution and cAMP Regulation | Biochemical and Biophysical Research Communications | 1993 | 151 |
| 50 | A Syndrome of Hypocalciuric Hypercalcemia Caused by Autoantibodies Directed at the Calcium-Sensing Receptor | Journal of Clinical Endocrinology and Metabolism | 2003 | 148 |
