| # | Title | Journal | Year | Citations |
|---|
| 1 | Calcific aortic stenosis | Nature Reviews Disease Primers | 2016 | 568 |
| 2 | Low-Flow, Low-Gradient Aortic Stenosis With Normal and Depressed Left Ventricular Ejection Fraction | Journal of the American College of Cardiology | 2012 | 368 |
| 3 | Paradoxical low flow and/or low gradient severe aortic stenosis despite preserved left ventricular ejection fraction: implications for diagnosis and treatment | European Heart Journal | 2010 | 293 |
| 4 | Association of estimated sleep duration and naps with mortality and cardiovascular events: a study of 116 632 people from 21 countries | European Heart Journal | 2019 | 208 |
| 5 | Improving Assessment of Aortic Stenosis | Journal of the American College of Cardiology | 2012 | 160 |
| 6 | Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis | Nature Medicine | 2014 | 103 |
| 7 | miR-223 reverses experimental pulmonary arterial hypertension | American Journal of Physiology - Cell Physiology | 2015 | 103 |
| 8 | OX40L blockade and allergen‐induced airway responses in subjects with mild asthma | Clinical and Experimental Allergy | 2014 | 89 |
| 9 | Incidence, risk factors, clinical impact, and management of bioprosthesis structural valve degeneration | Current Opinion in Cardiology | 2017 | 87 |
| 10 | Timing of intervention in aortic stenosis: a review of current and future strategies | Heart | 2018 | 82 |
| 11 | Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 70 |
| 12 | Haemodynamic and anatomic progression of aortic stenosis | Heart | 2015 | 67 |
| 13 | Profile of past and current clinical trials involving endothelin receptor antagonists: the novel "-sentan" class of drug | Experimental Biology and Medicine | 2006 | 60 |
| 14 | Multiple and Mixed Valvular Heart Diseases | Circulation: Cardiovascular Imaging | 2018 | 57 |
| 15 | Low-Molecular-Weight Peptides from Salmon Protein Prevent Obesity-Linked Glucose Intolerance, Inflammation, and Dyslipidemia in LDLR−/−/ApoB100/100 Mice | Journal of Nutrition | 2015 | 53 |
| 16 | Androgens and the Regulation of Adiposity and Body Fat Distribution in Humans | | 2018 | 53 |
| 17 | Transapical Transcatheter Aortic Valve Replacement Is Associated With Increased Cardiac Mortality in Patients With Left Ventricular Dysfunction | JACC: Cardiovascular Interventions | 2017 | 52 |
| 18 | Human β-Defensin 2 Mediated Immune Modulation as Treatment for Experimental Colitis | Frontiers in Immunology | 2020 | 52 |
| 19 | Enhancement of glucose uptake in muscular cell by peptide fractions separated by electrodialysis with filtration membrane from salmon frame protein hydrolysate | Journal of Functional Foods | 2016 | 49 |
| 20 | Enhancement of glucose uptake in muscular cell by soybean charged peptides isolated by electrodialysis with ultrafiltration membranes (EDUF): Activation of the AMPK pathway | Food Chemistry | 2014 | 47 |
| 21 | Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice | Diabetologia | 2016 | 47 |
| 22 | Management of Paradoxical Low-Flow, Low-Gradient Aortic Stenosis | Journal of the American College of Cardiology | 2015 | 39 |
| 23 | Modulation and roles of the endothelins in the pathophysiology of pulmonary embolism | Canadian Journal of Physiology and Pharmacology | 2003 | 36 |
| 24 | Standardized Definitions for Bioprosthetic Valve Dysfunction Following Aortic or Mitral Valve Replacement | Journal of the American College of Cardiology | 2022 | 34 |
| 25 | CGS 35601, a Triple Inhibitor of Angiotensin Converting Enzyme, Neutral Endopeptidase and Endothelin Converting Enzyme | Cardiovascular Drug Reviews | 2006 | 33 |
| 26 | Exercise and Asthma | Seminars in Respiratory and Critical Care Medicine | 2018 | 32 |
| 27 | Statin-Induced Insulin Resistance Through Inflammasome Activation: Sailing Between Scylla and Charybdis | Diabetes | 2014 | 29 |
| 28 | Peroxisome proliferator‐activated receptor γ activation favours selective subcutaneous lipid deposition by coordinately regulating lipoprotein lipase modulators, fatty acid transporters and lipogenic enzymes | Acta Physiologica | 2016 | 29 |
| 29 | Assessment of aortic stenosis severity: when the gradient does not fit with the valve area | Heart | 2010 | 28 |
| 30 | Cost Effectiveness of Ventricular Tachycardia Ablation Versus Escalation of Antiarrhythmic Drug Therapy | JACC: Clinical Electrophysiology | 2018 | 27 |
| 31 | Clinical value of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases | American Journal of Physiology - Cell Physiology | 2020 | 26 |
| 32 | Aortic Stenosis: Look Globally, Think Globally | JACC: Cardiovascular Imaging | 2009 | 25 |
| 33 | miRNAs in PAH: biomarker, therapeutic target or both? | Drug Discovery Today | 2014 | 25 |
| 34 | Pathobiology of Lp(a) in calcific aortic valve disease | Expert Review of Cardiovascular Therapy | 2017 | 23 |
| 35 | Predictors of Ventricular Arrhythmias and Sudden Death in a Québec Cohort With Brugada Syndrome | Canadian Journal of Cardiology | 2016 | 19 |
| 36 | The Role of Imaging in Measuring Disease Progression and Assessing Novel Therapies in Aortic Stenosis | JACC: Cardiovascular Imaging | 2019 | 18 |
| 37 | Inhibition of mitochondrial complex 1 by the S6K1 inhibitor PF-4708671 partly contributes to its glucose metabolic effects in muscle and liver cells | Journal of Biological Chemistry | 2019 | 16 |
| 38 | Triple Vasopeptidase Inhibition Normalizes Blood Pressure in Conscious, Unrestrained, and Spontaneously Hypertensive Rats | American Journal of Hypertension | 2005 | 15 |
| 39 | The Obesity Paradox in Aortic Stenosis | Journal of the American College of Cardiology | 2013 | 15 |
| 40 | Role of the Endothelin System in Secondary Pulmonary Hypertension Related to Air Embolism: Lessons Learned from Testing Four Classes of Endothelin Blockers in a Rat Model | Journal of Cardiovascular Pharmacology | 2004 | 14 |
| 41 | Does the length dependency of airway smooth muscle force contribute to airway hyperresponsiveness? | Journal of Applied Physiology | 2013 | 14 |
| 42 | Dietary sucrose induces metabolic inflammation and atherosclerotic cardiovascular diseases more than dietary fat in LDLr ApoB100/100 mice | Atherosclerosis | 2020 | 14 |
| 43 | Imaging of Valvular Heart Disease | Canadian Journal of Cardiology | 2013 | 13 |
| 44 | Total Synthesis of the Antidiabetic (Type 2) Lipid Mediator Protectin DX/PDX | Journal of Organic Chemistry | 2019 | 13 |
| 45 | Triaging Access to Critical Care Resources in Patients With Chronic Respiratory Diseases in the Event of a Major COVID-19 Surge | Chest | 2020 | 12 |
| 46 | EFFECT OF ECE AND NEP INHIBITION ON CIGARETTE SMOKE-INDUCED CELL PROLIFERATION IN THE RAT LUNG | Inhalation Toxicology | 2001 | 11 |
| 47 | Percutaneous versus surgical delivery of autologous myoblasts after chronic myocardial infarction: An in vivo cardiovascular magnetic resonance study | Catheterization and Cardiovascular Interventions | 2010 | 11 |
| 48 | Potential therapeutic applications of the gut microbiome in obesity: from brain function to body detoxification | International Journal of Obesity | 2020 | 10 |
| 49 | Contraction to big endothelin-1, big endothelin-2 and big endothelin-3, and endothelin-converting enzyme inhibition in human isolated bronchi | British Journal of Pharmacology | 2000 | 9 |
| 50 | A novel procedure for daily measurements of hemodynamical, hematological, and biochemical parameters in conscious unrestrained rats | Journal of Pharmacological and Toxicological Methods | 2000 | 9 |
