| # | Title | Journal | Year | Citations |
|---|
| 1 | Origin and evolution of the adaptive immune system: genetic events and selective pressures | Nature Reviews Genetics | 2010 | 753 |
| 2 | Antiviral Potential of ERK/MAPK and PI3K/AKT/mTOR Signaling Modulation for Middle East Respiratory Syndrome Coronavirus Infection as Identified by Temporal Kinome Analysis | Antimicrobial Agents and Chemotherapy | 2015 | 344 |
| 3 | Comparative Genomics of the MHC | Immunity | 2001 | 335 |
| 4 | Comparative analyses of immunoglobulin genes: surprises and portents | Nature Reviews Immunology | 2002 | 334 |
| 5 | Biofilms in periprosthetic orthopedic infections | Future Microbiology | 2014 | 267 |
| 6 | An Angiogenic Switch in Macrophages Involving Synergy between Toll-Like Receptors 2, 4, 7, and 9 and Adenosine A2A Receptors | American Journal of Pathology | 2003 | 250 |
| 7 | Rickettsial Infection inDermacentor variabilis(Acari: Ixodidae) Inhibits Transovarial Transmission of a SecondRickettsia | Journal of Medical Entomology | 2002 | 246 |
| 8 | A cold-blooded view of adaptive immunity | Nature Reviews Immunology | 2018 | 242 |
| 9 | Evidence Supporting a Zoonotic Origin of Human Coronavirus Strain NL63 | Journal of Virology | 2012 | 239 |
| 10 | Metagenomic Analysis of the Viromes of Three North American Bat Species: Viral Diversity among Different Bat Species That Share a Common Habitat | Journal of Virology | 2010 | 194 |
| 11 | Tobacco Smoking Inhibits Expression of Proinflammatory Cytokines and Activation of IL-1R-Associated Kinase, p38, and NF-κB in Alveolar Macrophages Stimulated with TLR2 and TLR4 Agonists | Journal of Immunology | 2007 | 170 |
| 12 | Association of TLR4 Polymorphisms with Symptomatic Respiratory Syncytial Virus Infection in High-Risk Infants and Young Children | Journal of Immunology | 2007 | 168 |
| 13 | Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice. | Journal of Experimental Medicine | 1996 | 161 |
| 14 | A Case Of Convergence: Why Did a Simple Alternative to Canonical Antibodies Arise in Sharks and Camels? | PLoS Biology | 2011 | 159 |
| 15 | The role of epidermal growth factor receptor (EGFR) signaling in SARS coronavirus-induced pulmonary fibrosis | Antiviral Research | 2017 | 152 |
| 16 | The germinal center: a crucible for lymphocyte selection | Seminars in Immunology | 1996 | 142 |
| 17 | The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis | Journal of Experimental Medicine | 2007 | 137 |
| 18 | Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference | Journal of Virology | 2015 | 133 |
| 19 | Antibodies to N-terminal peptides of gonococcal porin are bactericidal when gonococcal lipopolysaccharide is not sialylated | Molecular Microbiology | 1992 | 129 |
| 20 | Maturation of Shark Single-domain (IgNAR) Antibodies: Evidence for Induced-fit Binding | Journal of Molecular Biology | 2007 | 127 |
| 21 | Hsp60 chaperonopathies and chaperonotherapy: targets and agents | Expert Opinion on Therapeutic Targets | 2014 | 122 |
| 22 | Toll-Like Receptor 2 Is Required for Inflammatory Responses to Francisella tularensis LVS | Infection and Immunity | 2006 | 121 |
| 23 | Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus | Journal of General Virology | 2014 | 111 |
| 24 | Binding of a C-type lectin’s coiled-coil domain to the Domeless receptor directly activates the JAK/STAT pathway in the shrimp immune response to bacterial infection | PLoS Pathogens | 2017 | 110 |
| 25 | Iron-responsive bacterial small RNAs: variations on a theme | Metallomics | 2013 | 105 |
| 26 | Endosymbiont DNA in Endobacteria-Free Filarial Nematodes Indicates Ancient Horizontal Genetic Transfer | PLoS ONE | 2010 | 105 |
| 27 | High-affinity lamprey VLRA and VLRB monoclonal antibodies | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 104 |
| 28 | The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling | Journal of General Virology | 2014 | 99 |
| 29 | Structural analysis, selection, and ontogeny of the shark new antigen receptor (IgNAR): identification of a new locus preferentially expressed in early development | Immunogenetics | 2002 | 97 |
| 30 | The plasticity of immunoglobulin gene systems in evolution | Immunological Reviews | 2006 | 95 |
| 31 | Standards for Sequencing Viral Genomes in the Era of High-Throughput Sequencing | MBio | 2014 | 89 |
| 32 | Induction of Alternatively Activated Macrophages Enhances Pathogenesis during Severe Acute Respiratory Syndrome Coronavirus Infection | Journal of Virology | 2012 | 88 |
| 33 | Clearance of Staphylococcus aureus Nasal Carriage Is T Cell Dependent and Mediated through Interleukin-17A Expression and Neutrophil Influx | Infection and Immunity | 2013 | 88 |
| 34 | Extensive genomic diversity of closely related Wolbachia strains | Microbiology (United Kingdom) | 2009 | 87 |
| 35 | Isoform-Specific Regulation of the Na+/Ca2+Exchanger in Rat Astrocytes and Neurons by PKA | Journal of Neuroscience | 1998 | 81 |
| 36 | Evolutionarily Conserved TCR Binding Sites, Identification of T Cells in Primary Lymphoid Tissues, and Surprising Trans-Rearrangements in Nurse Shark | Journal of Immunology | 2010 | 77 |
| 37 | Cholera Toxin and Heat-Labile Enterotoxin Activate Human Monocyte-Derived Dendritic Cells and Dominantly Inhibit Cytokine Production through a Cyclic AMP-Dependent Pathway | Infection and Immunity | 2002 | 75 |
| 38 | Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes. | Journal of Experimental Medicine | 1995 | 74 |
| 39 | Cutting Edge: Differential Inhibition of TLR Signaling Pathways by Cell-Permeable Peptides Representing BB Loops of TLRs | Journal of Immunology | 2007 | 72 |
| 40 | Re-evaluation of the Immunological Big Bang | Current Biology | 2014 | 71 |
| 41 | One-Health: a Safe, Efficient, Dual-Use Vaccine for Humans and Animals against Middle East Respiratory Syndrome Coronavirus and Rabies Virus | Journal of Virology | 2017 | 69 |
| 42 | Candida–Bacteria Interactions: Their Impact on Human Disease | Microbiology Spectrum | 2016 | 68 |
| 43 | Infection and Transovarial Transmission of Rickettsiae inDermacentor variabilisTicks Acquired by Artificial Feeding | Vector-Borne and Zoonotic Diseases | 2001 | 67 |
| 44 | Skeletal muscle Heat shock protein 60 increases after endurance training and induces peroxisome proliferator-activated receptor gamma coactivator 1 α1 expression | Scientific Reports | 2016 | 67 |
| 45 | A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 66 |
| 46 | Induction of cytotoxic T cell responses in newborn mice by DNA immunization | Vaccine | 1997 | 64 |
| 47 | γδ T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells | Current Biology | 1996 | 63 |
| 48 | Functional differences between cardiac and renal isoforms of the rat Na + ‐Ca 2+ exchanger NCX1 expressed in Xenopus oocytes | Journal of Physiology | 2000 | 63 |
| 49 | The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity | Virology Journal | 2014 | 58 |
| 50 | Surface Proteome Analysis and Characterization of Surface Cell Antigen (Sca) or Autotransporter Family of Rickettsia typhi | PLoS Pathogens | 2012 | 57 |
