| # | Title | Journal | Year | Citations |
|---|
| 1 | A General Framework for Weighted Gene Co-Expression Network Analysis | Statistical Applications in Genetics and Molecular Biology | 2005 | 4,608 |
| 2 | Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning | Nature | 2008 | 2,039 |
| 3 | Defining clusters from a hierarchical cluster tree: the Dynamic Tree Cut package for R | Bioinformatics | 2008 | 1,665 |
| 4 | Transcriptomic analysis of autistic brain reveals convergent molecular pathology | Nature | 2011 | 1,654 |
| 5 | An epigenetic biomarker of aging for lifespan and healthspan | Aging | 2018 | 1,552 |
| 6 | Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism | Neuron | 2011 | 1,146 |
| 7 | DNA methylation GrimAge strongly predicts lifespan and healthspan | Aging | 2019 | 1,128 |
| 8 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 9 | Mapping genomic loci implicates genes and synaptic biology in schizophrenia | Nature | 2022 | 929 |
| 10 | Common genetic variants on 5p14.1 associate with autism spectrum disorders | Nature | 2009 | 912 |
| 11 | Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons | Nature Neuroscience | 2010 | 892 |
| 12 | Is My Network Module Preserved and Reproducible? | PLoS Computational Biology | 2011 | 885 |
| 13 | Mapping the Genetic Architecture of Gene Expression in Human Liver | PLoS Biology | 2008 | 872 |
| 14 | Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap | Science | 2018 | 851 |
| 15 | Epigenetic Predictor of Age | PLoS ONE | 2011 | 781 |
| 16 | The family based association test method: strategies for studying general genotype–phenotype associations | European Journal of Human Genetics | 2001 | 696 |
| 17 | Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain | Nature Neuroscience | 2014 | 663 |
| 18 | Gene Expression Profiling of Gliomas Strongly Predicts Survival | Cancer Research | 2004 | 659 |
| 19 | Mutations in Two Genes Encoding Different Subunits of a Receptor Signaling Complex Result in an Identical Disease Phenotype | American Journal of Human Genetics | 2002 | 611 |
| 20 | Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens | Nature Neuroscience | 2010 | 553 |
| 21 | Comparative Analysis of Proteome and Transcriptome Variation in Mouse | PLoS Genetics | 2011 | 548 |
| 22 | Aging effects on DNA methylation modules in human brain and blood tissue | Genome Biology | 2012 | 536 |
| 23 | Epigenetic clock analysis of diet, exercise, education, and lifestyle factors | Aging | 2017 | 521 |
| 24 | The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR | Nature | 2014 | 485 |
| 25 | BFAST: An Alignment Tool for Large Scale Genome Resequencing | PLoS ONE | 2009 | 444 |
| 26 | Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts | Nature Genetics | 2000 | 436 |
| 27 | Regulatory T cell development in the absence of functional Foxp3 | Nature Immunology | 2007 | 427 |
| 28 | Reprogramming to recover youthful epigenetic information and restore vision | Nature | 2020 | 424 |
| 29 | Integrating Genetic and Network Analysis to Characterize Genes Related to Mouse Weight | PLoS Genetics | 2006 | 419 |
| 30 | Aire deficient mice develop multiple features of APECED phenotype and show altered immune response | Human Molecular Genetics | 2002 | 409 |
| 31 | Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies | Aging | 2018 | 406 |
| 32 | DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling | Development (Cambridge) | 2005 | 371 |
| 33 | C-terminal truncations in human 3′-5′ DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy | Nature Genetics | 2007 | 366 |
| 34 | The Human Phenome Project | Nature Genetics | 2003 | 356 |
| 35 | Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system | Journal of Neuroscience Research | 2005 | 356 |
| 36 | A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis | Nature Neuroscience | 2005 | 350 |
| 37 | Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients | Aging | 2015 | 344 |
| 38 | Weighted gene coexpression network analysis strategies applied to mouse weight | Mammalian Genome | 2007 | 337 |
| 39 | Natural selection interacts with recombination to shape the evolution of hybrid genomes | Science | 2018 | 314 |
| 40 | Epidermal Growth Factor Receptor Activation in Glioblastoma through Novel Missense Mutations in the Extracellular Domain | PLoS Medicine | 2006 | 298 |
| 41 | Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance | Nature Medicine | 2010 | 280 |
| 42 | Exercise impacts brain‐derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation | European Journal of Neuroscience | 2011 | 280 |
| 43 | FEAST: fast expectation-maximization for microbial source tracking | Nature Methods | 2019 | 275 |
| 44 | Probabilistic fine-mapping of transcriptome-wide association studies | Nature Genetics | 2019 | 275 |
| 45 | CHAC1/MGC4504 Is a Novel Proapoptotic Component of the Unfolded Protein Response, Downstream of the ATF4-ATF3-CHOP Cascade | Journal of Immunology | 2009 | 255 |
| 46 | Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration | Nature Genetics | 2017 | 252 |
| 47 | The Number of X Chromosomes Causes Sex Differences in Adiposity in Mice | PLoS Genetics | 2012 | 247 |
| 48 | When Is Hub Gene Selection Better than Standard Meta-Analysis? | PLoS ONE | 2013 | 243 |
| 49 | Single-Cell Transcriptome Analyses Reveal Signals to Activate Dormant Neural Stem Cells | Cell | 2015 | 239 |
| 50 | Transcriptional Architecture of the Primate Neocortex | Neuron | 2012 | 234 |
