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| DNA methylation pathways and their crosstalk with histone methylation | Nature Reviews Molecular Cell Biology | 2015 | 558 |
| Collapse of the world's largest herbivores | Science Advances | 2015 | 509 |
| Alternative Wnt Signaling Activates YAP/TAZ | Cell | 2015 | 393 |
| CTFS-ForestGEO: a worldwide network monitoring forests in an era of global change | Global Change Biology | 2015 | 368 |
| Modeling infectious disease dynamics in the complex landscape of global health | Science | 2015 | 324 |
| Sympathetic nervous system regulation of the tumour microenvironment | Nature Reviews Cancer | 2015 | 284 |
| Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality | Cell Reports | 2015 | 258 |
| Large-scale imputation of epigenomic datasets for systematic annotation of diverse human tissues | Nature Biotechnology | 2015 | 252 |
| Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells | Blood | 2015 | 240 |
| DNA Demethylation Dynamics in the Human Prenatal Germline | Cell | 2015 | 231 |
| The Genome 10K Project: a way forward | Annual Review of Animal Biosciences | 2015 | 223 |
| The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study | PLoS Genetics | 2015 | 220 |
| Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling | Cell | 2015 | 203 |
| Development of mesoporous silica-based nanoparticles with controlled release capability for cancer therapy | Advanced Drug Delivery Reviews | 2015 | 193 |
| Target enrichment of ultraconserved elements from arthropods provides a genomic perspective on relationships among Hymenoptera | Molecular Ecology Resources | 2015 | 175 |
| Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity | ELife | 2015 | 171 |
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| A One Precursor One siRNA Model for Pol IV-Dependent siRNA Biogenesis | Cell | 2015 | 166 |
| Healthy aging: The ultimate preventative medicine | Science | 2015 | 164 |
| Rare allele of a previously unidentified histone H4 acetyltransferase enhances grain weight, yield, and plant biomass in rice | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 156 |
| Genome-wide identification of CCA1 targets uncovers an expanded clock network in Arabidopsis | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 156 |
| Noninvasive Reactivation of Motor Descending Control after Paralysis | Journal of Neurotrauma | 2015 | 154 |
| Increased tolerance to humans among disturbed wildlife | Nature Communications | 2015 | 153 |
| How Nature-Based Tourism Might Increase Prey Vulnerability to Predators | Trends in Ecology and Evolution | 2015 | 151 |
