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Top Articles

#TitleJournalYearCitations
1Phase II, Randomized Trial Comparing Bevacizumab Plus Fluorouracil (FU)/Leucovorin (LV) With FU/LV Alone in Patients With Metastatic Colorectal CancerJournal of Clinical Oncology20031,618
2Activity of the Dual Kinase Inhibitor Lapatinib (GW572016) against HER-2-Overexpressing and Trastuzumab-Treated Breast Cancer CellsCancer Research2006846
3Anti-PD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumabAnnals of Oncology2017641
4Assessment of Methods for Tissue-Based Detection of the HER-2/neu Alteration in Human Breast Cancer: A Direct Comparison of Fluorescence In Situ Hybridization and ImmunohistochemistryJournal of Clinical Oncology2000627
5Zoledronic acid reduces skeletal-related events in patients with osteolytic metastasesCancer2001494
6PD-1 Blockade Expands Intratumoral Memory T CellsCancer Immunology Research2016321
7The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cellsOncogene1997317
8Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and DegradationMolecular and Cellular Proteomics2003302
9sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistanceNature2016290
10Current Developments in Cancer Vaccines and Cellular ImmunotherapyJournal of Clinical Oncology2003287
11Activated Phosphoinositide 3-Kinase/AKT Signaling Confers Resistance to Trastuzumab but not LapatinibMolecular Cancer Therapeutics2010283
12An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to ImmunotherapyCancer Research2016265
13PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunityNature Immunology2004232
14Releasing the Brakes on Cancer ImmunotherapyNew England Journal of Medicine2015207
15The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of non-small cell lung cancer (NSCLC)2018188
16Regulation of cytokine signaling pathways by PIAS proteinsCell Research2006182
17PARP inhibitors for BRCA1/2-mutated and sporadic ovarian cancer: current practice and future directionsBritish Journal of Cancer2016163
18Current and future role of neoadjuvant therapy for breast cancerBreast2014162
19Role of the Aggresome Pathway in Cancer: Targeting Histone Deacetylase 6–Dependent Protein DegradationCancer Research2008155
20Social Stress Enhances Sympathetic Innervation of Primate Lymph Nodes: Mechanisms and Implications for Viral PathogenesisJournal of Neuroscience2007146
21Proinflammatory Stimuli Induce IKKα-Mediated Phosphorylation of PIAS1 to Restrict Inflammation and ImmunityCell2007145
22The Oncogenic BRAF Kinase Inhibitor PLX4032/RG7204 Does Not Affect the Viability or Function of Human Lymphocytes across a Wide Range of ConcentrationsClinical Cancer Research2010142
23HER-2/neu Gene Amplification and Response to Paclitaxel in Patients With Metastatic Breast CancerJournal of the National Cancer Institute2004139
24Negative Regulation of NF-κB Signaling by PIAS1Molecular and Cellular Biology2005138
25A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse modelBlood2010132
26Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancerOncotarget2013132
27Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-κB-dependent mechanismMolecular Cancer Therapeutics2008129
28Venetoclax for patients with chronic lymphocytic leukemia who progressed during or after idelalisib therapyBlood2018122
29Different Patterns of Akt and ERK Feedback Activation in Response to Rapamycin, Active-Site mTOR Inhibitors and Metformin in Pancreatic Cancer CellsPLoS ONE2013118
30Preoperative β-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized TrialClinical Cancer Research2020113
31Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumorsJournal of Neuro-Oncology2009111
32Phase II Multicenter Study of Arsenic Trioxide in Patients With Myelodysplastic SyndromesJournal of Clinical Oncology2006106
33Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarumNature Communications2018106
34Acute kidney injury in patients treated with immune checkpoint inhibitors2021103
35PIASx Is a Transcriptional Co-repressor of Signal Transducer and Activator of Transcription 4Journal of Biological Chemistry2003101
36Regulation of protein tyrosine phosphatase 1B by sumoylationNature Cell Biology2007100
37Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cellsProceedings of the National Academy of Sciences of the United States of America201197
38Therapeutic Potential of the Poly(ADP-ribose) Polymerase Inhibitor Rucaparib for the Treatment of Sporadic Human Ovarian CancerMolecular Cancer Therapeutics201393
39Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse modelOncotarget201691
40Clinical outcomes of patients with advanced gastrointestinal stromal tumors: Safety and efficacy in a worldwide treatment‐use trial of sunitinibCancer201589
41Periostin promotes ovarian cancer angiogenesis and metastasisGynecologic Oncology201088
42Activity of the multikinase inhibitor dasatinib against ovarian cancer cellsBritish Journal of Cancer200981
43Cocaine and  -1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID modelJournal of Leukocyte Biology200575
44New Challenges in Endpoints for Drug Development in Advanced MelanomaClinical Cancer Research201272
45Advances in Targeted Therapies for Triple-Negative Breast CancerDrugs201971
46Activity of the Fibroblast Growth Factor Receptor Inhibitors Dovitinib (TKI258) and NVP-BGJ398 in Human Endometrial Cancer CellsMolecular Cancer Therapeutics201369
47A Pilot Trial of the Combination of Transgenic NY-ESO-1–reactive Adoptive Cellular Therapy with Dendritic Cell Vaccination with or without IpilimumabClinical Cancer Research201969
48Functional and Oncological Outcomes of Partial Nephrectomy of Solitary KidneysJournal of Urology200967
49Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse modelOncotarget201767
50Monocyte Function in ManJournal of Immunology197766