| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response | Science | 2006 | 3,367 |
| 3 | Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis | Nature Medicine | 2013 | 3,355 |
| 4 | Molecular determinants of resistance to antiandrogen therapy | Nature Medicine | 2004 | 2,117 |
| 5 | RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E) | Nature | 2011 | 1,298 |
| 6 | Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006) | Lancet, The | 2017 | 1,032 |
| 7 | Biological Actions of Androgens | Endocrine Reviews | 1987 | 1,012 |
| 8 | Vertebral Fractures and Mortality in Older Women | Archives of Internal Medicine | 1999 | 928 |
| 9 | Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis | Nature Genetics | 2004 | 900 |
| 10 | Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials | BMJ: British Medical Journal | 2004 | 899 |
| 11 | Identification of erythroferrone as an erythroid regulator of iron metabolism | Nature Genetics | 2014 | 890 |
| 12 | Activity of the Dual Kinase Inhibitor Lapatinib (GW572016) against HER-2-Overexpressing and Trastuzumab-Treated Breast Cancer Cells | Cancer Research | 2006 | 846 |
| 13 | Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages | Proceedings of the National Academy of Sciences of the United States of America | 1980 | 836 |
| 14 | Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation | Cell Metabolism | 2013 | 794 |
| 15 | Epigenetic Predictor of Age | PLoS ONE | 2011 | 781 |
| 16 | The weight of leptin in immunity | Nature Reviews Immunology | 2004 | 780 |
| 17 | Impact of Major Bleeding on 30-Day Mortality and Clinical Outcomes in Patients With Acute Coronary Syndromes | Journal of the American College of Cardiology | 2007 | 776 |
| 18 | ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation | Cell Metabolism | 2005 | 754 |
| 19 | New mitochondrial DNA synthesis enables NLRP3 inflammasome activation | Nature | 2018 | 722 |
| 20 | A new technique for measurement of cardiac output by thermodilution in man | American Journal of Cardiology | 1971 | 710 |
| 21 | Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures. | Journal of Clinical Investigation | 1995 | 699 |
| 22 | Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein. | Journal of Clinical Investigation | 1991 | 669 |
| 23 | A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis | Cell | 1993 | 658 |
| 24 | Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers | American Journal of Respiratory and Critical Care Medicine | 2013 | 655 |
| 25 | Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder | Journal of Experimental Medicine | 2008 | 644 |
| 26 | A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model | Journal of Neuroscience | 2005 | 641 |
| 27 | Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure | Journal of the American College of Cardiology | 2002 | 640 |
| 28 | The Role of the Transcription Factor CREB in Immune Function | Journal of Immunology | 2010 | 638 |
| 29 | Inter and intraobserver variability of total skin thickness score (modified Rodnan TSS) in systemic sclerosis | Journal of Rheumatology | 1995 | 638 |
| 30 | Reprogramming human T cell function and specificity with non-viral genome targeting | Nature | 2018 | 630 |
| 31 | Age Influence on the Immune System | Advances in Immunology | 1980 | 627 |
| 32 | Assessment of Methods for Tissue-Based Detection of the HER-2/neu Alteration in Human Breast Cancer: A Direct Comparison of Fluorescence In Situ Hybridization and Immunohistochemistry | Journal of Clinical Oncology | 2000 | 627 |
| 33 | Diagnosis and Management of Rhinitis: Complete Guidelines of the Joint Task Force on Practice Parameters in Allergy, Asthma and Immunology | Annals of Allergy, Asthma and Immunology | 1998 | 599 |
| 34 | Antibodies to DNA | New England Journal of Medicine | 1998 | 585 |
| 35 | Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome | Cell Metabolism | 2012 | 568 |
| 36 | Effect of Growth Hormone on Carbohydrate and Lipid Metabolism | Endocrine Reviews | 1987 | 566 |
| 37 | Antitumor Activity in Melanoma and Anti-Self Responses in a Phase I Trial With the Anti-Cytotoxic T Lymphocyte–Associated Antigen 4 Monoclonal Antibody CP-675,206 | Journal of Clinical Oncology | 2005 | 563 |
| 38 | An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease | Genome Biology | 2016 | 535 |
| 39 | Mechanisms and Metabolic Implications of Regional Differences among Fat Depots | Cell Metabolism | 2013 | 507 |
| 40 | Cardiac Myocyte Cell Cycle Control in Development, Disease, and Regeneration | Physiological Reviews | 2007 | 501 |
| 41 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 493 |
| 42 | AACE/ADA Consensus Statement | Endocrine Practice | 2009 | 472 |
| 43 | Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab | Journal of Surgical Oncology | 2005 | 471 |
| 44 | Sex difference and smoking predisposition in patients with COVID-19 | Lancet Respiratory Medicine,the | 2020 | 463 |
| 45 | Association Between mRNA Vaccination and COVID-19 Hospitalization and Disease Severity | JAMA - Journal of the American Medical Association | 2021 | 458 |
| 46 | Sarcopenia Exacerbates Obesity-Associated Insulin Resistance and Dysglycemia: Findings from the National Health and Nutrition Examination Survey III | PLoS ONE | 2010 | 457 |
| 47 | Tumor Cyclooxygenase-2/Prostaglandin E2–Dependent Promotion of FOXP3 Expression and CD4+CD25+ T Regulatory Cell Activities in Lung Cancer | Cancer Research | 2005 | 452 |
| 48 | The Stromal Derived Factor–1/CXCL12–CXC Chemokine Receptor 4 Biological Axis in Non–Small Cell Lung Cancer Metastases | American Journal of Respiratory and Critical Care Medicine | 2003 | 438 |
| 49 | Identification of a Nuclear Stat1 Protein Tyrosine Phosphatase | Molecular and Cellular Biology | 2002 | 435 |
| 50 | A prospective study of predictors of adherence to combination antiretroviral medication | Journal of General Internal Medicine | 2002 | 433 |
