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Top Articles

#TitleJournalYearCitations
1Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary FibrosisAmerican Journal of Respiratory and Critical Care Medicine2019866
2Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life spanJournal of Experimental Medicine2017755
3Circuits between infected macrophages and T cells in SARS-CoV-2 pneumoniaNature2021524
4Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growthNature2015386
5The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma developmentNature Medicine2015359
6Born to run: control of transcription elongation by RNA polymerase IINature Reviews Molecular Cell Biology2018304
7Lung transplantation for patients with severe COVID-19Science Translational Medicine2020246
8Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulationNature Genetics2020209
9Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophagesNature Metabolism2020206
10PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase IICell2015196
11Chromatin signatures of cancerGenes and Development2015171
12Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of NucleotidesCancers2019167
13Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of MutationCell Reports2017164
14Enhancer Logic and Mechanics in Development and DiseaseTrends in Cell Biology2018146
15Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical dataTrends in Food Science and Technology2020146
16Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting StrategiesFrontiers in Immunology2020131
17MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor GenesMolecular Cell2018123
18Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemiaNature Genetics2020118
19Identification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virusAntiviral Research2017113
20Promoter bivalency favors an open chromatin architecture in embryonic stem cellsNature Genetics2018113
21Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundariesNature Communications2018112
22Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memoryELife2016107
23Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MSNature Protocols2019106
24A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancerOncogene2018102
25PAF1 regulation of promoter-proximal pause release via enhancer activationScience201795
26An integrative ENCODE resource for cancer genomicsNature Communications202095
27Mislocalization of centromeric histone H3 variant CENP-A contributes to chromosomal instability (CIN) in human cellsOncotarget201792
28The lung microenvironment shapes a dysfunctional response of alveolar macrophages in agingJournal of Clinical Investigation202186
29Direct stimulation of NADP + synthesis through Akt-mediated phosphorylation of NAD kinaseScience201985
30Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase ComplexCell201884
31Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell SpecificationMolecular Cell201781
32Emerging concepts of epigenetic dysregulation in hematological malignanciesNature Immunology201677
33Signal Percolation within a Bacterial CommunityCell Systems201877
34Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulationGenome Biology202070
35HiC-bench: comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarkingBMC Genomics201769
36HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanicsELife202169
37A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia PathogenesisCancer Cell201868
38USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell LeukemiaClinical Cancer Research201966
39The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cellsScience202264
40Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanismELife201762
41Subtype-specific 3D genome alteration in acute myeloid leukaemiaNature202259
42mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial functionProceedings of the National Academy of Sciences of the United States of America201857
43Genome-wide mapping of human DNA replication by optical replication mapping supports a stochastic model of eukaryotic replicationMolecular Cell202157
44Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activityGenes and Development201655
45An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cellsScience Advances201855
46Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasisScience Translational Medicine201855
47A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylationGenes and Development201754
48A PRC2-independent function for EZH2 in regulating rRNA 2′-O methylation and IRES-dependent translationNature Cell Biology202154
49The phytochemical, biological, and medicinal attributes of phytoecdysteroids: An updated reviewActa Pharmaceutica Sinica B202151
50SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expressionGenes and Development201748