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#TitleJournalYearCitations
1A mutation in Orai1 causes immune deficiency by abrogating CRAC channel functionNature20062,016
2Orai1 is an essential pore subunit of the CRAC channelNature20061,223
3A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput ScreeningJournal of Medicinal Chemistry20021,013
4A Specific Mechanism of Nonspecific InhibitionJournal of Medicinal Chemistry2003583
5Insights into G Protein Structure, Function, and RegulationEndocrine Reviews2003565
6Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and toleranceNature Immunology2008528
7Identification and Prediction of Promiscuous Aggregating Inhibitors among Known DrugsJournal of Medicinal Chemistry2003467
8Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C PhosphatasesScience2012439
9Lead discovery using molecular dockingCurrent Opinion in Chemical Biology2002429
10Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptorProceedings of the National Academy of Sciences of the United States of America2002401
11Ion channels and transporters in lymphocyte function and immunityNature Reviews Immunology2012364
12Selective MT 2 melatonin receptor antagonists block melatonin‐mediated phase advances of circadian rhythmsFASEB Journal1998345
13Melatonin receptors: Role on sleep and circadian rhythm regulationSleep Medicine2007290
14Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiaeNature Genetics2008279
15Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1Molecular and Cellular Biology2008275
16Information Decay in Molecular Docking Screens against Holo, Apo, and Modeled Conformations of EnzymesJournal of Medicinal Chemistry2003266
17Direct Observation of Nanoparticle–Cancer Cell Nucleus InteractionsACS Nano2012251
18Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific proteaseNature Genetics2002250
19Structural basis of JAZ repression of MYC transcription factors in jasmonate signallingNature2015248
20Heterodimeric GTPase Core of the SRP Targeting ComplexScience2004246
21Kinase Inhibitors:  Not Just for Kinases AnymoreJournal of Medicinal Chemistry2003245
22Targeting protein kinases in central nervous system disordersNature Reviews Drug Discovery2009244
23Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffoldsBiomaterials2013244
24Bone regeneration mediated by biomimetic mineralization of a nanofiber matrixBiomaterials2010241
25Kainate receptors coming of age: milestones of two decades of researchTrends in Neurosciences2011241
26The Calcineurin/Nuclear Factor of Activated T Cells Signaling Pathway Regulates Osteoclastogenesis in RAW264.7 CellsJournal of Biological Chemistry2004238
27CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritisProceedings of the National Academy of Sciences of the United States of America2012231
28Chemokine receptors are expressed widely by embryonic and adult neural progenitor cellsJournal of Neuroscience Research2004227
29Osteoarthritis joint pain: The cytokine connectionCytokine2014213
30STIM1–Orai1 interactions and Orai1 conformational changes revealed by live‐cell FRET microscopyJournal of Physiology2008195
31Epidermal growth factor (EGF)- and scatter factor/hepatocyte growth factor (SF/HGF)-mediated keratinocyte migration is coincident with induction of matrix metalloproteinase (MMP)-91998190
32Alzheimer's therapeutics: Continued clinical failures question the validity of the amyloid hypothesis—but what lies beyond?Biochemical Pharmacology2013181
33Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL ProteaseJournal of Medicinal Chemistry2013178
34Astrocytes in glaucomatous optic neuropathyProgress in Brain Research2008177
35The nanometer-scale structure of amyloid-Β visualized by atomic force microscopyThe Protein Journal1996168
36Selective Methylation of Histone H3 Variant H3.1 Regulates Heterochromatin ReplicationScience2014165
37Use of non-mammalian alternative models for neurotoxicological studyNeuroToxicology2008154
38Sulfated glycopeptide nanostructures for multipotent protein activationNature Nanotechnology2017148
39MT2Melatonin Receptors Are Present and Functional in Rat Caudal ArteryJournal of Pharmacology and Experimental Therapeutics2002144
40Combined Loss of Cdk2 and Cdk4 Results in Embryonic Lethality and Rb HypophosphorylationDevelopmental Cell2006141
41Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressorsScience Advances2015140
42The Chemokine Stromal Cell-Derived Factor-1 Regulates GABAergic Inputs to Neural Progenitors in the Postnatal Dentate GyrusJournal of Neuroscience2008133
43Hypoxia Leads to Na,K-ATPase Downregulation via Ca2+ Release-Activated Ca2+ Channels and AMPK ActivationMolecular and Cellular Biology2011127
44The structural basis of R-spondin recognition by LGR5 and RNF43Genes and Development2013124
45Structure-Based Approach for Binding Site Identification on AmpC β-LactamaseJournal of Medicinal Chemistry2002123
46Store-Operated CRAC Channels Regulate Gene Expression and Proliferation in Neural Progenitor CellsJournal of Neuroscience2014123
47Melatonin desensitizes endogenous MT 2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatoninFASEB Journal2004120
48Visualization of Chemokine Receptor Activation in Transgenic Mice Reveals Peripheral Activation of CCR2 Receptors in States of Neuropathic PainJournal of Neuroscience2009120
49Structure-Based Discovery of a Novel, Noncovalent Inhibitor of AmpC β-LactamaseStructure2002119
50Orai1 Mutations Alter Ion Permeation and Ca2+-dependent Fast Inactivation of CRAC Channels: Evidence for Coupling of Permeation and GatingJournal of General Physiology2007114