# | Title | Journal | Year | Citations |
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1 | A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function | Nature | 2006 | 2,016 |
2 | Orai1 is an essential pore subunit of the CRAC channel | Nature | 2006 | 1,223 |
3 | A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening | Journal of Medicinal Chemistry | 2002 | 1,013 |
4 | A Specific Mechanism of Nonspecific Inhibition | Journal of Medicinal Chemistry | 2003 | 583 |
5 | Insights into G Protein Structure, Function, and Regulation | Endocrine Reviews | 2003 | 565 |
6 | Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance | Nature Immunology | 2008 | 528 |
7 | Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs | Journal of Medicinal Chemistry | 2003 | 467 |
8 | Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases | Science | 2012 | 439 |
9 | Lead discovery using molecular docking | Current Opinion in Chemical Biology | 2002 | 429 |
10 | Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 401 |
11 | Ion channels and transporters in lymphocyte function and immunity | Nature Reviews Immunology | 2012 | 364 |
12 | Selective MT 2 melatonin receptor antagonists block melatonin‐mediated phase advances of circadian rhythms | FASEB Journal | 1998 | 345 |
13 | Melatonin receptors: Role on sleep and circadian rhythm regulation | Sleep Medicine | 2007 | 290 |
14 | Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae | Nature Genetics | 2008 | 279 |
15 | Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1 | Molecular and Cellular Biology | 2008 | 275 |
16 | Information Decay in Molecular Docking Screens against Holo, Apo, and Modeled Conformations of Enzymes | Journal of Medicinal Chemistry | 2003 | 266 |
17 | Direct Observation of Nanoparticle–Cancer Cell Nucleus Interactions | ACS Nano | 2012 | 251 |
18 | Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease | Nature Genetics | 2002 | 250 |
19 | Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling | Nature | 2015 | 248 |
20 | Heterodimeric GTPase Core of the SRP Targeting Complex | Science | 2004 | 246 |
21 | Kinase Inhibitors: Not Just for Kinases Anymore | Journal of Medicinal Chemistry | 2003 | 245 |
22 | Targeting protein kinases in central nervous system disorders | Nature Reviews Drug Discovery | 2009 | 244 |
23 | Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds | Biomaterials | 2013 | 244 |
24 | Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix | Biomaterials | 2010 | 241 |
25 | Kainate receptors coming of age: milestones of two decades of research | Trends in Neurosciences | 2011 | 241 |
26 | The Calcineurin/Nuclear Factor of Activated T Cells Signaling Pathway Regulates Osteoclastogenesis in RAW264.7 Cells | Journal of Biological Chemistry | 2004 | 238 |
27 | CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 231 |
28 | Chemokine receptors are expressed widely by embryonic and adult neural progenitor cells | Journal of Neuroscience Research | 2004 | 227 |
29 | Osteoarthritis joint pain: The cytokine connection | Cytokine | 2014 | 213 |
30 | STIM1–Orai1 interactions and Orai1 conformational changes revealed by live‐cell FRET microscopy | Journal of Physiology | 2008 | 195 |
31 | Epidermal growth factor (EGF)- and scatter factor/hepatocyte growth factor (SF/HGF)-mediated keratinocyte migration is coincident with induction of matrix metalloproteinase (MMP)-9 | | 1998 | 190 |
32 | Alzheimer's therapeutics: Continued clinical failures question the validity of the amyloid hypothesis—but what lies beyond? | Biochemical Pharmacology | 2013 | 181 |
33 | Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease | Journal of Medicinal Chemistry | 2013 | 178 |
34 | Astrocytes in glaucomatous optic neuropathy | Progress in Brain Research | 2008 | 177 |
35 | The nanometer-scale structure of amyloid-Β visualized by atomic force microscopy | The Protein Journal | 1996 | 168 |
36 | Selective Methylation of Histone H3 Variant H3.1 Regulates Heterochromatin Replication | Science | 2014 | 165 |
37 | Use of non-mammalian alternative models for neurotoxicological study | NeuroToxicology | 2008 | 154 |
38 | Sulfated glycopeptide nanostructures for multipotent protein activation | Nature Nanotechnology | 2017 | 148 |
39 | MT2Melatonin Receptors Are Present and Functional in Rat Caudal Artery | Journal of Pharmacology and Experimental Therapeutics | 2002 | 144 |
40 | Combined Loss of Cdk2 and Cdk4 Results in Embryonic Lethality and Rb Hypophosphorylation | Developmental Cell | 2006 | 141 |
41 | Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors | Science Advances | 2015 | 140 |
42 | The Chemokine Stromal Cell-Derived Factor-1 Regulates GABAergic Inputs to Neural Progenitors in the Postnatal Dentate Gyrus | Journal of Neuroscience | 2008 | 133 |
43 | Hypoxia Leads to Na,K-ATPase Downregulation via Ca2+ Release-Activated Ca2+ Channels and AMPK Activation | Molecular and Cellular Biology | 2011 | 127 |
44 | The structural basis of R-spondin recognition by LGR5 and RNF43 | Genes and Development | 2013 | 124 |
45 | Structure-Based Approach for Binding Site Identification on AmpC β-Lactamase | Journal of Medicinal Chemistry | 2002 | 123 |
46 | Store-Operated CRAC Channels Regulate Gene Expression and Proliferation in Neural Progenitor Cells | Journal of Neuroscience | 2014 | 123 |
47 | Melatonin desensitizes endogenous MT 2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin | FASEB Journal | 2004 | 120 |
48 | Visualization of Chemokine Receptor Activation in Transgenic Mice Reveals Peripheral Activation of CCR2 Receptors in States of Neuropathic Pain | Journal of Neuroscience | 2009 | 120 |
49 | Structure-Based Discovery of a Novel, Noncovalent Inhibitor of AmpC β-Lactamase | Structure | 2002 | 119 |
50 | Orai1 Mutations Alter Ion Permeation and Ca2+-dependent Fast Inactivation of CRAC Channels: Evidence for Coupling of Permeation and Gating | Journal of General Physiology | 2007 | 114 |