| # | Title | Journal | Year | Citations |
|---|
|
| 1 | A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity | Science | 2012 | 13,436 |
| 2 | Near-optimal probabilistic RNA-seq quantification | Nature Biotechnology | 2016 | 7,902 |
| 3 | The Genome Sequence of Drosophila melanogaster | Science | 2000 | 5,617 |
| 4 | The new frontier of genome engineering with CRISPR-Cas9 | Science | 2014 | 5,067 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,789 |
| 6 | Short-Term Synaptic Plasticity | Annual Review of Physiology | 2002 | 4,045 |
| 7 | Molecular Basis of Bacterial Outer Membrane Permeability Revisited | Microbiology and Molecular Biology Reviews | 2003 | 3,459 |
| 8 | The Free Radical Theory of Aging Matures | Physiological Reviews | 1998 | 3,364 |
| 9 | Differential analysis of gene regulation at transcript resolution with RNA-seq | Nature Biotechnology | 2013 | 3,337 |
| 10 | Cellular and Molecular Mechanisms of Pain | Cell | 2009 | 3,210 |
| 11 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,158 |
| 12 | The Ubiquitin Code | Annual Review of Biochemistry | 2012 | 2,964 |
| 13 | Innate or Adaptive Immunity? The Example of Natural Killer Cells | Science | 2011 | 2,294 |
| 14 | Animals in a bacterial world, a new imperative for the life sciences | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 2,287 |
| 15 | Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA | Nature | 2000 | 2,193 |
| 16 | Impact of Culture-Independent Studies on the Emerging Phylogenetic View of Bacterial Diversity | Journal of Bacteriology | 1998 | 2,177 |
| 17 | Cell Surface Engineering by a Modified Staudinger Reaction | Science | 2000 | 2,160 |
| 18 | Phase transitions in the assembly of multivalent signalling proteins | Nature | 2012 | 2,059 |
| 19 | The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis | Nature | 2019 | 2,055 |
| 20 | The Evolution and Future of Earth’s Nitrogen Cycle | Science | 2010 | 2,040 |
| 21 | CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. | Journal of Experimental Medicine | 1995 | 1,965 |
| 22 | RNA-programmed genome editing in human cells | ELife | 2013 | 1,884 |
| 23 | Analysis of genetic mosaics in developing and adult Drosophila tissues | Development (Cambridge) | 1993 | 1,866 |
| 24 | Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics | BMC Genomics | 2018 | 1,809 |
| 25 | Appendix G: In Situ Hybridization: An Improved Whole-Mount Method for Xenopus Embryos | Methods in Cell Biology | 1991 | 1,800 |
| 26 | Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion | Nature Cell Biology | 2009 | 1,795 |
| 27 | Chemical Glycobiology | Science | 2001 | 1,762 |
| 28 | Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature | Natural Product Reports | 2013 | 1,755 |
| 29 | Alpha-lipoic acid as a biological antioxidant | Free Radical Biology and Medicine | 1995 | 1,726 |
| 30 | Normalization of RNA-seq data using factor analysis of control genes or samples | Nature Biotechnology | 2014 | 1,678 |
| 31 | The genomic basis of adaptive evolution in threespine sticklebacks | Nature | 2012 | 1,650 |
| 32 | DNA interrogation by the CRISPR RNA-guided endonuclease Cas9 | Nature | 2014 | 1,643 |
| 33 | Neurotrophin regulation of neural circuit development and function | Nature Reviews Neuroscience | 2013 | 1,636 |
| 34 | Copper-free click chemistry for dynamic in vivo imaging | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 1,628 |
| 35 | Neurotrophins as synaptic modulators | Nature Reviews Neuroscience | 2001 | 1,611 |
| 36 | Comparative Genomics of the Eukaryotes | Science | 2000 | 1,583 |
| 37 | The complete sequence of a human genome | Science | 2022 | 1,565 |
| 38 | Spike Timing–Dependent Plasticity: A Hebbian Learning Rule | Annual Review of Neuroscience | 2008 | 1,560 |
| 39 | Phase separation drives heterochromatin domain formation | Nature | 2017 | 1,537 |
| 40 | CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones | Nature | 1992 | 1,524 |
| 41 | The amphioxus genome and the evolution of the chordate karyotype | Nature | 2008 | 1,523 |
| 42 | The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4 | Cell | 1996 | 1,492 |
| 43 | Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 1,489 |
| 44 | Cu-free click cycloaddition reactions in chemical biology | Chemical Society Reviews | 2010 | 1,446 |
| 45 | CRISPR–Cas9 Structures and Mechanisms | Annual Review of Biophysics | 2017 | 1,414 |
| 46 | Three-Dimensional Resolution Doubling in Wide-Field Fluorescence Microscopy by Structured Illumination | Biophysical Journal | 2008 | 1,412 |
| 47 | The developmental transcriptome of Drosophila melanogaster | Nature | 2011 | 1,406 |
| 48 | An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor | Cell | 2006 | 1,391 |
| 49 | Differential analysis of RNA-seq incorporating quantification uncertainty | Nature Methods | 2017 | 1,368 |
| 50 | Synaptic Modification by Correlated Activity: Hebb's Postulate Revisited | Annual Review of Neuroscience | 2001 | 1,355 |
