| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions | Science | 2007 | 2,354 |
| 3 | Antioxidant and redox regulation of gene transcription | FASEB Journal | 1996 | 1,851 |
| 4 | Appendix G: In Situ Hybridization: An Improved Whole-Mount Method for Xenopus Embryos | Methods in Cell Biology | 1991 | 1,775 |
| 5 | CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones | Nature | 1992 | 1,516 |
| 6 | Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation | Nature Genetics | 2002 | 1,294 |
| 7 | ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase | Nature Cell Biology | 2013 | 1,255 |
| 8 | Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells | Science | 1993 | 1,128 |
| 9 | Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos | Cell | 1992 | 1,093 |
| 10 | Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine. | Proceedings of the National Academy of Sciences of the United States of America | 1990 | 1,023 |
| 11 | Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering | Cell | 2016 | 889 |
| 12 | CTLA-4: new insights into its biological function and use in tumor immunotherapy | Nature Immunology | 2002 | 843 |
| 13 | ICOS co-stimulatory receptor is essential for T-cell activation and function | Nature | 2001 | 840 |
| 14 | The Nitric Oxide-Scavenging Properties of Ginkgo Biloba Extract EGb 761 | Biochemical and Biophysical Research Communications | 1994 | 819 |
| 15 | Building ubiquitin chains: E2 enzymes at work | Nature Reviews Molecular Cell Biology | 2009 | 816 |
| 16 | Condensin-driven remodelling of X chromosome topology during dosage compensation | Nature | 2015 | 787 |
| 17 | Comprehensive analysis of the chromatin landscape in Drosophila melanogaster | Nature | 2011 | 781 |
| 18 | Immuno-PCR: very sensitive antigen detection by means of specific antibody-DNA conjugates | Science | 1992 | 778 |
| 19 | The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch | Cell | 2013 | 772 |
| 20 | BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1 | Nature Immunology | 2003 | 768 |
| 21 | The Toll and Imd pathways are the major regulators of the immune response in Drosophila | EMBO Journal | 2002 | 754 |
| 22 | Neural Induction by the Secreted Polypeptide Noggin | Science | 1993 | 747 |
| 23 | Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway | Cell | 1990 | 726 |
| 24 | Fidelity Mechanisms in DNA Replication | Annual Review of Biochemistry | 1991 | 714 |
| 25 | Dishevelled controls cell polarity during Xenopus gastrulation | Nature | 2000 | 705 |
| 26 | Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins | Nature | 1990 | 691 |
| 27 | Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1 | Nature | 1998 | 690 |
| 28 | The Establishment, Inheritance, and Function of Silenced Chromatin inSaccharomyces cerevisiae | Annual Review of Biochemistry | 2003 | 678 |
| 29 | Starting at the Beginning, Middle, and End: Translation Initiation in Eukaryotes | Cell | 1997 | 667 |
| 30 | Crystal structure of the ATP-binding subunit of an ABC transporter | Nature | 1998 | 667 |
| 31 | Orchestrated response: a symphony of transcription factors for gene control | Genes and Development | 2000 | 647 |
| 32 | Mutations affecting growth cone guidance in drosophila: Genes necessary for guidance toward or away from the midline | Neuron | 1993 | 641 |
| 33 | Harnessing actin dynamics for clathrin-mediated endocytosis | Nature Reviews Molecular Cell Biology | 2006 | 636 |
| 34 | Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center | Cell | 1991 | 629 |
| 35 | The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription | Nature | 2001 | 629 |
| 36 | Computational identification of Drosophila microRNA genes | Genome Biology | 2003 | 624 |
| 37 | Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism | Nature | 2015 | 624 |
| 38 | Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G. | EMBO Journal | 1996 | 617 |
| 39 | A Pathway for Association of Receptors, Adaptors, and Actin during Endocytic Internalization | Cell | 2003 | 617 |
| 40 | Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators | Cell | 1993 | 607 |
| 41 | VIVE LA DIFFÉRENCE: Males vs Females in Flies vs Worms | Annual Review of Genetics | 1996 | 602 |
| 42 | Systematic determination of patterns of gene expression during Drosophila embryogenesis | Genome Biology | 2002 | 600 |
| 43 | The lysosome as a cellular centre for signalling, metabolism and quality control | Nature Cell Biology | 2019 | 599 |
| 44 | The promise and challenge of therapeutic genome editing | Nature | 2020 | 599 |
| 45 | Phospho-Regulation of Kinetochore-Microtubule Attachments by the Aurora Kinase Ipl1p | Cell | 2002 | 575 |
| 46 | Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria | FEMS Microbiology Reviews | 2012 | 574 |
| 47 | Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase | Nature | 1999 | 568 |
| 48 | Telomerase in the human organism | Oncogene | 2002 | 558 |
| 49 | DOCK 6: Impact of new features and current docking performance | Journal of Computational Chemistry | 2015 | 552 |
| 50 | miR-19 is a key oncogenic component of mir-17-92 | Genes and Development | 2009 | 540 |
