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#TitleJournalYearCitations
1Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimeticNature2012430
2Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in miceBritish Journal of Pharmacology2008167
3Localized delivery of fibroblast growth factor–2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy modelProceedings of the National Academy of Sciences of the United States of America2009134
4Are the neurotrophic factors a suitable therapeutic target for the prevention of epileptogenesis?Epilepsia2010106
5In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptorPeptides200772
6Finding a better drug for epilepsy: Preclinical screening strategies and experimental trial designEpilepsia201269
7The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled ReceptorStructure201564
8Neuropeptide S produces hyperlocomotion and prevents oxidative stress damage in the mouse brain: A comparative study with amphetamine and diazepamPharmacology Biochemistry and Behavior200957
9G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged miceNeurobiology of Disease201856
10Activities of mixed NOP and μ‐opioid receptor ligandsBritish Journal of Pharmacology200855
11Synthesis and Biological Activity of Human Neuropeptide S Analogues Modified in Position 5: Identification of Potent and Pure Neuropeptide S Receptor AntagonistsJournal of Medicinal Chemistry200953
12Pharmacological characterization of cebranopadol a novel analgesic acting as mixed nociceptin/orphanin FQ and opioid receptor agonistPharmacology Research and Perspectives201651
13Selective Breeding for High Anxiety Introduces a Synonymous SNP That Increases Neuropeptide S Receptor ActivityJournal of Neuroscience201550
14Enhancement of GABA A -current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsyProceedings of the National Academy of Sciences of the United States of America201049
15Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug AddictionNeuropsychopharmacology201749
16The nociceptin/orphanin FQ-NOP receptor antagonist effects on an animal model of sepsisIntensive Care Medicine200846
17Safinamide Differentially Modulates In Vivo Glutamate and GABA Release in the Rat Hippocampus and Basal GangliaJournal of Pharmacology and Experimental Therapeutics201842
18Pharmacological Profile of Nociceptin/Orphanin FQ Receptors Interacting with G-Proteins and β-Arrestins 2PLoS ONE201540
19Beta-arrestin 2 rather than G protein efficacy determines the anxiolytic-versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligandsNeuropharmacology201640
20FGF-2 Overexpression Increases Excitability and Seizure Susceptibility but Decreases Seizure-Induced Cell LossJournal of Neuroscience200833
21Hypothalamic Neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the ratPsychopharmacology201333
22A novel and facile synthesis of tetra branched derivatives of nociceptin/orphanin FQBioorganic and Medicinal Chemistry201432
23A staged screening of registered drugs highlights remyelinating drug candidates for clinical trialsScientific Reports201731
24Blockade of nociceptin/orphanin FQ receptor signaling reverses LPS-induced depressive-like behavior in micePeptides201529
25In vitro and in vivo pharmacological characterization of nociceptin/orphanin FQ tetrabranched derivativesBritish Journal of Pharmacology201428
26Structure–activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4′-piperidin-1-yl]propyl} pyrrolidine-2-carboxamideBioorganic and Medicinal Chemistry200927
27Engineered HSV vector achieves safe long-term transgene expression in the central nervous systemScientific Reports201727
28Genetic deletion of Rhes or pharmacological blockade of mTORC1 prevent striato-nigral neurons activation in levodopa-induced dyskinesiaNeurobiology of Disease201626
29Characterisation of the Novel Mixed Mu-NOP Peptide Ligand Dermorphin-N/OFQ (DeNo)PLoS ONE201626
30Spinal antinociceptive effects of the novel NOP receptor agonist PWT2‐nociceptin/orphanin FQ in mice and monkeysBritish Journal of Pharmacology201525
31Nociceptin/Orphanin FQ-NOP Receptor System in Inflammatory and Immune-Mediated DiseasesVitamins and Hormones201525
32In vitro and in vivo pharmacological characterization of the synthetic opioid MT-45Neuropharmacology202022
33Binding of the novel radioligand [3H]UFP-101 to recombinant human and native rat nociceptin/orphanin FQ receptorsNaunyn-Schmiedeberg's Archives of Pharmacology200821
34Intrathecal administration of nociceptin/orphanin FQ receptor agonists in rats: A strategy to relieve chemotherapy-induced neuropathic hypersensitivityEuropean Journal of Pharmacology201521
35Blockade of adenosine A2A receptor counteracts neuropeptide-S-induced hyperlocomotion in miceNaunyn-Schmiedeberg's Archives of Pharmacology201020
36Central adenosine A1 and A2A receptors mediate the antinociceptive effects of neuropeptide S in the mouse formalin testLife Sciences201520
37Proposal for a “phase II” multicenter trial model for preclinical new antiepilepsy therapy developmentEpilepsia201319
38Neuropeptide S counteracts 6-OHDA-induced motor deficits in miceBehavioural Brain Research201419
39Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in ratsEuropean Journal of Pharmacology201518
40Antinociceptive action of NOP and opioid receptor agonists in the mouse orofacial formalin testPeptides201718
41Endogenous neuropeptide S tone influences sleep–wake rhythm in ratsNeuroscience Letters201417
42Nociceptin/Orphanin FQ (N/OFQ) conjugated to ATTO594: a novel fluorescent probe for the N/OFQ (NOP) receptorBritish Journal of Pharmacology201817
43Effects of neuropeptide S on seizures and oxidative damage induced by pentylenetetrazole in micePharmacology Biochemistry and Behavior201216
44Neuropeptide S reduces mouse aggressiveness in the resident/intruder test through selective activation of the neuropeptide S receptorNeuropharmacology201516
45Anti‐Parkinsonian and anti‐dyskinetic profiles of two novel potent and selective nociceptin/orphanin FQ receptor agonistsBritish Journal of Pharmacology201816
46Modulation of the NOP receptor signaling affects resilience to acute stressJournal of Psychopharmacology201916
47Pharmacological characterization of tachykinin tetrabranched derivativesBritish Journal of Pharmacology201415
48Protein Kinase C β: a New Target Therapy to Prevent the Long-Term Atypical Antipsychotic-Induced Weight GainNeuropsychopharmacology201715
49Activation of nociceptin/orphanin FQ receptors inhibits contextual fear memory reconsolidationNeuropharmacology201715
50Harmonization in preclinical epilepsy research: A joint AES/ILAE translational initiativeEpilepsia201715