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Section of Pharmacology
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top-articles
Section of Pharmacology
75
(top 1%)
papers
2.4K
(top 1%)
citations
26
(top 1%)
h
-index
48
(top 1%)
g
-index
76
all documents
2.5K
doc citations
567
citing journals
Top Articles
#
Title
Journal
Year
Citations
1
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic
Nature
2012
430
2
Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice
British Journal of Pharmacology
2008
167
3
Localized delivery of fibroblast growth factor–2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy model
Proceedings of the National Academy of Sciences of the United States of America
2009
134
4
Are the neurotrophic factors a suitable therapeutic target for the prevention of epileptogenesis?
Epilepsia
2010
106
5
In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor
Peptides
2007
72
6
Finding a better drug for epilepsy: Preclinical screening strategies and experimental trial design
Epilepsia
2012
69
7
The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor
Structure
2015
64
8
Neuropeptide S produces hyperlocomotion and prevents oxidative stress damage in the mouse brain: A comparative study with amphetamine and diazepam
Pharmacology Biochemistry and Behavior
2009
57
9
G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice
Neurobiology of Disease
2018
56
10
Activities of mixed NOP and μ‐opioid receptor ligands
British Journal of Pharmacology
2008
55
11
Synthesis and Biological Activity of Human Neuropeptide S Analogues Modified in Position 5: Identification of Potent and Pure Neuropeptide S Receptor Antagonists
Journal of Medicinal Chemistry
2009
53
12
Pharmacological characterization of cebranopadol a novel analgesic acting as mixed nociceptin/orphanin FQ and opioid receptor agonist
Pharmacology Research and Perspectives
2016
51
13
Selective Breeding for High Anxiety Introduces a Synonymous SNP That Increases Neuropeptide S Receptor Activity
Journal of Neuroscience
2015
50
14
Enhancement of GABA
A
-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy
Proceedings of the National Academy of Sciences of the United States of America
2010
49
15
Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction
Neuropsychopharmacology
2017
49
16
The nociceptin/orphanin FQ-NOP receptor antagonist effects on an animal model of sepsis
Intensive Care Medicine
2008
46
17
Safinamide Differentially Modulates In Vivo Glutamate and GABA Release in the Rat Hippocampus and Basal Ganglia
Journal of Pharmacology and Experimental Therapeutics
2018
42
18
Pharmacological Profile of Nociceptin/Orphanin FQ Receptors Interacting with G-Proteins and β-Arrestins 2
PLoS ONE
2015
40
19
Beta-arrestin 2 rather than G protein efficacy determines the anxiolytic-versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligands
Neuropharmacology
2016
40
20
FGF-2 Overexpression Increases Excitability and Seizure Susceptibility but Decreases Seizure-Induced Cell Loss
Journal of Neuroscience
2008
33
21
Hypothalamic Neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the rat
Psychopharmacology
2013
33
22
A novel and facile synthesis of tetra branched derivatives of nociceptin/orphanin FQ
Bioorganic and Medicinal Chemistry
2014
32
23
A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials
Scientific Reports
2017
31
24
Blockade of nociceptin/orphanin FQ receptor signaling reverses LPS-induced depressive-like behavior in mice
Peptides
2015
29
25
In vitro
and
in vivo
pharmacological characterization of nociceptin/orphanin
FQ
tetrabranched derivatives
British Journal of Pharmacology
2014
28
26
Structure–activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4′-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide
Bioorganic and Medicinal Chemistry
2009
27
27
Engineered HSV vector achieves safe long-term transgene expression in the central nervous system
Scientific Reports
2017
27
28
Genetic deletion of Rhes or pharmacological blockade of mTORC1 prevent striato-nigral neurons activation in levodopa-induced dyskinesia
Neurobiology of Disease
2016
26
29
Characterisation of the Novel Mixed Mu-NOP Peptide Ligand Dermorphin-N/OFQ (DeNo)
PLoS ONE
2016
26
30
Spinal antinociceptive effects of the novel
NOP
receptor agonist
PWT2
‐nociceptin/orphanin
FQ
in mice and monkeys
British Journal of Pharmacology
2015
25
31
Nociceptin/Orphanin FQ-NOP Receptor System in Inflammatory and Immune-Mediated Diseases
Vitamins and Hormones
2015
25
32
In vitro and in vivo pharmacological characterization of the synthetic opioid MT-45
Neuropharmacology
2020
22
33
Binding of the novel radioligand [3H]UFP-101 to recombinant human and native rat nociceptin/orphanin FQ receptors
Naunyn-Schmiedeberg's Archives of Pharmacology
2008
21
34
Intrathecal administration of nociceptin/orphanin FQ receptor agonists in rats: A strategy to relieve chemotherapy-induced neuropathic hypersensitivity
European Journal of Pharmacology
2015
21
35
Blockade of adenosine A2A receptor counteracts neuropeptide-S-induced hyperlocomotion in mice
Naunyn-Schmiedeberg's Archives of Pharmacology
2010
20
36
Central adenosine A1 and A2A receptors mediate the antinociceptive effects of neuropeptide S in the mouse formalin test
Life Sciences
2015
20
37
Proposal for a “phase
II
” multicenter trial model for preclinical new antiepilepsy therapy development
Epilepsia
2013
19
38
Neuropeptide S counteracts 6-OHDA-induced motor deficits in mice
Behavioural Brain Research
2014
19
39
Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats
European Journal of Pharmacology
2015
18
40
Antinociceptive action of NOP and opioid receptor agonists in the mouse orofacial formalin test
Peptides
2017
18
41
Endogenous neuropeptide S tone influences sleep–wake rhythm in rats
Neuroscience Letters
2014
17
42
Nociceptin/Orphanin
FQ
(N/OFQ) conjugated to
ATTO
594: a novel fluorescent probe for the N/OFQ (NOP) receptor
British Journal of Pharmacology
2018
17
43
Effects of neuropeptide S on seizures and oxidative damage induced by pentylenetetrazole in mice
Pharmacology Biochemistry and Behavior
2012
16
44
Neuropeptide S reduces mouse aggressiveness in the resident/intruder test through selective activation of the neuropeptide S receptor
Neuropharmacology
2015
16
45
Anti‐Parkinsonian and anti‐dyskinetic profiles of two novel potent and selective nociceptin/orphanin FQ receptor agonists
British Journal of Pharmacology
2018
16
46
Modulation of the NOP receptor signaling affects resilience to acute stress
Journal of Psychopharmacology
2019
16
47
Pharmacological characterization of tachykinin tetrabranched derivatives
British Journal of Pharmacology
2014
15
48
Protein Kinase C β: a New Target Therapy to Prevent the Long-Term Atypical Antipsychotic-Induced Weight Gain
Neuropsychopharmacology
2017
15
49
Activation of nociceptin/orphanin FQ receptors inhibits contextual fear memory reconsolidation
Neuropharmacology
2017
15
50
Harmonization in preclinical epilepsy research: A joint AES/ILAE translational initiative
Epilepsia
2017
15
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