# | Title | Journal | Year | Citations |
---|
1 | The bone marrow niche for haematopoietic stem cells | Nature | 2014 | 1,910 |
2 | In vivo reprogramming of adult pancreatic exocrine cells to β-cells | Nature | 2008 | 1,892 |
3 | Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons | Science | 2008 | 1,826 |
4 | Generation of Functional Human Pancreatic β Cells In Vitro | Cell | 2014 | 1,643 |
5 | Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds | Nature Biotechnology | 2008 | 1,491 |
6 | M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination | Nature Neuroscience | 2013 | 1,357 |
7 | Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2 | Nature Biotechnology | 2008 | 1,249 |
8 | Somatic coding mutations in human induced pluripotent stem cells | Nature | 2011 | 1,147 |
9 | In vivo gene editing in dystrophic mouse muscle and muscle stem cells | Science | 2016 | 889 |
10 | A Small-Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog | Cell Stem Cell | 2009 | 741 |
11 | Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle | Science | 2014 | 706 |
12 | Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells | Genome Research | 2015 | 614 |
13 | Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons | Cell Reports | 2014 | 583 |
14 | Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice | Nature Medicine | 2016 | 564 |
15 | Rejuvenation of Regeneration in the Aging Central Nervous System | Cell Stem Cell | 2012 | 552 |
16 | Generation of pluripotent stem cells from patients with type 1 diabetes | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 534 |
17 | Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells | Nature Cell Biology | 2011 | 529 |
18 | A High-Efficiency System for the Generation and Study of Human Induced Pluripotent Stem Cells | Cell Stem Cell | 2008 | 508 |
19 | A multifunctional AAV–CRISPR–Cas9 and its host response | Nature Methods | 2016 | 506 |
20 | Epigenetic reprogramming and induced pluripotency | Development (Cambridge) | 2009 | 478 |
21 | A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice | Nature Biotechnology | 2016 | 476 |
22 | Exome-wide association study of plasma lipids in >300,000 individuals | Nature Genetics | 2017 | 470 |
23 | Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells | Nature Cell Biology | 2015 | 463 |
24 | A small molecule that directs differentiation of human ESCs into the pancreatic lineage | Nature Chemical Biology | 2009 | 454 |
25 | A functionally characterized test set of human induced pluripotent stem cells | Nature Biotechnology | 2011 | 446 |
26 | Mesenchymal Cell Contributions to the Stem Cell Niche | Cell Stem Cell | 2015 | 444 |
27 | Guidelines and Techniques for the Generation of Induced Pluripotent Stem Cells | Cell Stem Cell | 2008 | 439 |
28 | SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy | Science | 2014 | 420 |
29 | Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells | Cell Stem Cell | 2009 | 404 |
30 | Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1 | Cell Stem Cell | 2014 | 392 |
31 | The Lkb1 metabolic sensor maintains haematopoietic stem cell survival | Nature | 2010 | 346 |
32 | Short-Term Calorie Restriction Enhances Skeletal Muscle Stem Cell Function | Cell Stem Cell | 2012 | 336 |
33 | Tgfβ Signal Inhibition Cooperates in the Induction of iPSCs and Replaces Sox2 and cMyc | Current Biology | 2009 | 328 |
34 | Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3 | Nature Biotechnology | 2012 | 322 |
35 | Progress toward the clinical application of patient-specific pluripotent stem cells | Journal of Clinical Investigation | 2010 | 310 |
36 | Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells | Journal of Cell Science | 2009 | 309 |
37 | miRNA malfunction causes spinal motor neuron disease | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 299 |
38 | Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse | Developmental Biology | 2013 | 298 |
39 | SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation | Nature | 2008 | 289 |
40 | Generation of stem cell-derived β-cells from patients with type 1 diabetes | Nature Communications | 2016 | 280 |
41 | Dynamic niches in the origination and differentiation of haematopoietic stem cells | Nature Reviews Molecular Cell Biology | 2011 | 268 |
42 | The bone marrow at the crossroads of blood and immunity | Nature Reviews Immunology | 2012 | 268 |
43 | Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2 | Genes and Development | 2019 | 264 |
44 | Notch signaling promotes airway mucous metaplasia and inhibits alveolar development | Development (Cambridge) | 2009 | 263 |
45 | Differentiated human stem cells resemble fetal, not adult, β cells | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 259 |
46 | CRISPR–Cas encoding of a digital movie into the genomes of a population of living bacteria | Nature | 2017 | 254 |
47 | Turning straw into gold: directing cell fate for regenerative medicine | Nature Reviews Genetics | 2011 | 253 |
48 | Extreme Makeover: Converting One Cell into Another | Cell Stem Cell | 2008 | 249 |
49 | The histone chaperone CAF-1 safeguards somatic cell identity | Nature | 2015 | 244 |
50 | Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection | Cell Stem Cell | 2016 | 234 |