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Top Articles

#TitleJournalYearCitations
1The bone marrow niche for haematopoietic stem cellsNature20141,910
2In vivo reprogramming of adult pancreatic exocrine cells to β-cellsNature20081,892
3Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor NeuronsScience20081,826
4Generation of Functional Human Pancreatic β Cells In VitroCell20141,643
5Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compoundsNature Biotechnology20081,491
6M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelinationNature Neuroscience20131,357
7Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2Nature Biotechnology20081,249
8Somatic coding mutations in human induced pluripotent stem cellsNature20111,147
9In vivo gene editing in dystrophic mouse muscle and muscle stem cellsScience2016889
10A Small-Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing NanogCell Stem Cell2009741
11Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal MuscleScience2014706
12Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cellsGenome Research2015614
13Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor NeuronsCell Reports2014583
14Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent miceNature Medicine2016564
15Rejuvenation of Regeneration in the Aging Central Nervous SystemCell Stem Cell2012552
16Generation of pluripotent stem cells from patients with type 1 diabetesProceedings of the National Academy of Sciences of the United States of America2009534
17Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cellsNature Cell Biology2011529
18A High-Efficiency System for the Generation and Study of Human Induced Pluripotent Stem CellsCell Stem Cell2008508
19A multifunctional AAV–CRISPR–Cas9 and its host responseNature Methods2016506
20Epigenetic reprogramming and induced pluripotencyDevelopment (Cambridge)2009478
21A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn miceNature Biotechnology2016476
22Exome-wide association study of plasma lipids in >300,000 individualsNature Genetics2017470
23Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cellsNature Cell Biology2015463
24A small molecule that directs differentiation of human ESCs into the pancreatic lineageNature Chemical Biology2009454
25A functionally characterized test set of human induced pluripotent stem cellsNature Biotechnology2011446
26Mesenchymal Cell Contributions to the Stem Cell NicheCell Stem Cell2015444
27Guidelines and Techniques for the Generation of Induced Pluripotent Stem CellsCell Stem Cell2008439
28SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophyScience2014420
29Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem CellsCell Stem Cell2009404
30Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1Cell Stem Cell2014392
31The Lkb1 metabolic sensor maintains haematopoietic stem cell survivalNature2010346
32Short-Term Calorie Restriction Enhances Skeletal Muscle Stem Cell FunctionCell Stem Cell2012336
33Tgfβ Signal Inhibition Cooperates in the Induction of iPSCs and Replaces Sox2 and cMycCurrent Biology2009328
34Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3Nature Biotechnology2012322
35Progress toward the clinical application of patient-specific pluripotent stem cellsJournal of Clinical Investigation2010310
36Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cellsJournal of Cell Science2009309
37miRNA malfunction causes spinal motor neuron diseaseProceedings of the National Academy of Sciences of the United States of America2010299
38Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouseDevelopmental Biology2013298
39SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradationNature2008289
40Generation of stem cell-derived β-cells from patients with type 1 diabetesNature Communications2016280
41Dynamic niches in the origination and differentiation of haematopoietic stem cellsNature Reviews Molecular Cell Biology2011268
42The bone marrow at the crossroads of blood and immunityNature Reviews Immunology2012268
43Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2Genes and Development2019264
44Notch signaling promotes airway mucous metaplasia and inhibits alveolar developmentDevelopment (Cambridge)2009263
45Differentiated human stem cells resemble fetal, not adult, β cellsProceedings of the National Academy of Sciences of the United States of America2014259
46CRISPR–Cas encoding of a digital movie into the genomes of a population of living bacteriaNature2017254
47Turning straw into gold: directing cell fate for regenerative medicineNature Reviews Genetics2011253
48Extreme Makeover: Converting One Cell into AnotherCell Stem Cell2008249
49The histone chaperone CAF-1 safeguards somatic cell identityNature2015244
50Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus InfectionCell Stem Cell2016234